LSFLAB01:	Listing of Subjects With [Criteria] Laboratory Values; Safety Analysis Set (Study jjcs - core)											
Treatment Group 	Subject ID 	Age (years) / Sex / Race 	Laboratory Test (unit) 	Assessment Date / Time (Study Daya) 	Visit 	Time Point 	Result 	FDA Threshold Level 	Change From Baseline 	Reference Range 	
Xanomeline High Dose 	01-701-1028 	71 / Male / White 	Alanine Aminotransferase (U/L) 	01AUG2013 / 00:00 (14) 	Cycle 02 	BEFORE TREATMENT 	30 N NCS 	L2 (>6.0 mmol/L) 	4 	6 - 35 	
 	 	 	 	04DEC2013 / 00:00 (139) 	Cycle 11 	BEFORE TREATMENT 	22 N NCS 	L1 (>1.694 mmol/L) 	-4 	<6 - 35 	
 	 	 	 	06JAN2014 / 00:00 (172) 	Cycle 13 	BEFORE TREATMENT 	24 N NCS 	L1 (<132 mmol/L) 	-2 	6 - 35 	
 	 	 	 	06NOV2013 / 00:00 (111) 	Cycle 09 	BEFORE TREATMENT 	24 N NCS 	L1 (>1.694 mmol/L) 	-2 	<6 - 35 	
 	 	 	 	09OCT2013 / 00:00 (83) 	Cycle 07 	BEFORE TREATMENT 	29 N NCS 	L3 (>15.0 10^9/L) 	3 	6 - 35 	
 	 	 	 	10SEP2013 / 00:00 (54) 	Cycle 05 	BEFORE TREATMENT 	33 N NCS 	L2 (<1.996 mmol/L) 	7 	<6 - 35 	
 	 	 	 	11JUL2013 / 00:00 (-8) 	Baseline 	BEFORE TREATMENT 	26 N NCS 	L1 (125-135 g/L) 	 	<6 - 35 	
 	 	 	 	14AUG2013 / 00:00 (27) 	Cycle 03 	BEFORE TREATMENT 	29 N NCS 	L2 (>3.387 mmol/L) 	3 	6 - 35 	
 	 	 	 	14JAN2014 / 00:00 (180) 	End Of Treatment 	BEFORE TREATMENT 	26 N NCS 	L2 (<1.996 mmol/L) 	0 	<6 - <35 	
 	 	 	 	29AUG2013 / 00:00 (42) 	Cycle 04 	BEFORE TREATMENT 	32 N CS 	L1 (>5.172 mmol/L) 	6 	6 - <35 	
 	 	 	Albumin (g/L) 	01AUG2013 / 00:00 (14) 	Cycle 02 	BEFORE TREATMENT 	42 N NCS 	L1 (<132 mmol/L) 	-2 	35 - <46 	
 	 	 	 	04DEC2013 / 00:00 (139) 	Cycle 11 	BEFORE TREATMENT 	40 N CS 	L2 (>6.206 mmol/L) 	-4 	35 - <46 	
 	 	 	 	06JAN2014 / 00:00 (172) 	Cycle 13 	BEFORE TREATMENT 	42 N NCS 	L2 (>6.206 mmol/L) 	-2 	35 - <46 	
 	 	 	 	06NOV2013 / 00:00 (111) 	Cycle 09 	BEFORE TREATMENT 	37 N NCS 	L2 (<1.996 mmol/L) 	-7 	<35 - <46 	
 	 	 	 	09OCT2013 / 00:00 (83) 	Cycle 07 	BEFORE TREATMENT 	44 N NCS 	L2 (<1.996 mmol/L) 	0 	35 - 46 	
 	 	 	 	10SEP2013 / 00:00 (54) 	Cycle 05 	BEFORE TREATMENT 	39 N CS 	 	-5 	35 - <46 	
 	 	 	 	11JUL2013 / 00:00 (-8) 	Baseline 	BEFORE TREATMENT 	44 N NCS 	L2 (>3.387 mmol/L) 	 	<35 - <46 	
 	 	 	 	14AUG2013 / 00:00 (27) 	Cycle 03 	BEFORE TREATMENT 	41 N NCS 	L1 (>1.694 mmol/L) 	-3 	<35 - <46 	
 	 	 	 	14JAN2014 / 00:00 (180) 	End Of Treatment 	BEFORE TREATMENT 	45 N CS 	L1 (>1.5x ULN Enzyme U/L) 	1 	35 - 46 	
 	 	 	 	29AUG2013 / 00:00 (42) 	Cycle 04 	BEFORE TREATMENT 	40 N NCS 	L1 (>5.172 mmol/L) 	-4 	35 - <46 	
 	 	 	Alkaline Phosphatase (U/L) 	01AUG2013 / 00:00 (14) 	Cycle 02 	BEFORE TREATMENT 	46 N NCS 	L1 (>5.172 mmol/L) 	2 	<35 - 115 	
 	 	 	 	04DEC2013 / 00:00 (139) 	Cycle 11 	BEFORE TREATMENT 	43 N CS 	L2 (>6.206 mmol/L) 	-1 	<35 - <115 	
 	 	 	 	06JAN2014 / 00:00 (172) 	Cycle 13 	BEFORE TREATMENT 	47 N CS 	L1 (125-135 g/L) 	3 	35 - <115 	
 	 	 	 	06NOV2013 / 00:00 (111) 	Cycle 09 	BEFORE TREATMENT 	36 N CS 	L2 (>6.206 mmol/L) 	-8 	35 - <115 	
 	 	 	 	09OCT2013 / 00:00 (83) 	Cycle 07 	BEFORE TREATMENT 	41 N NCS 	L1 (125-135 g/L) 	-3 	35 - 115 	
 	 	 	 	10SEP2013 / 00:00 (54) 	Cycle 05 	BEFORE TREATMENT 	40 N NCS 	L2 (>3.387 mmol/L) 	-4 	<35 - 115 	
 	 	 	 	11JUL2013 / 00:00 (-8) 	Baseline 	BEFORE TREATMENT 	44 N NCS 	L2 (>3.387 mmol/L) 	 	<35 - <115 	
 	 	 	 	14AUG2013 / 00:00 (27) 	Cycle 03 	BEFORE TREATMENT 	38 N NCS 	L1 (>2.620 mmol/L) 	-6 	35 - 115 	
 	 	 	 	14JAN2014 / 00:00 (180) 	End Of Treatment 	BEFORE TREATMENT 	40 N NCS 	L2 (<1.996 mmol/L) 	-4 	<35 - <115 	
 	 	 	 	29AUG2013 / 00:00 (42) 	Cycle 04 	BEFORE TREATMENT 	40 N CS 	L2 (>6.206 mmol/L) 	-4 	35 - 115 	
 	 	 	Anisocytes 	04DEC2013 / 00:00 (139) 	Cycle 11 	BEFORE TREATMENT 	1 NCS 	L2 (>6.206 mmol/L) 	 	 	
 	 	 	 	06NOV2013 / 00:00 (111) 	Cycle 09 	BEFORE TREATMENT 	1 NCS 	L1 (>5.172 mmol/L) 	 	 	
 	 	 	Aspartate Aminotransferase (U/L) 	01AUG2013 / 00:00 (14) 	Cycle 02 	BEFORE TREATMENT 	23 N NCS 	L2 (>3.387 mmol/L) 	-1 	<11 - 36 	
 	 	 	 	04DEC2013 / 00:00 (139) 	Cycle 11 	BEFORE TREATMENT 	21 N NCS 	L1 (<132 mmol/L) 	-3 	<11 - <36 	
 	 	 	 	06JAN2014 / 00:00 (172) 	Cycle 13 	BEFORE TREATMENT 	23 N NCS 	L1 (>2.620 mmol/L) 	-1 	<11 - 36 	
 	 	 	 	06NOV2013 / 00:00 (111) 	Cycle 09 	BEFORE TREATMENT 	18 N NCS 	L1 (>5.172 mmol/L) 	-6 	<11 - <36 	
 	 	 	 	09OCT2013 / 00:00 (83) 	Cycle 07 	BEFORE TREATMENT 	28 N NCS 	L1 (<132 mmol/L) 	4 	<11 - <36 	
 	 	 	 	10SEP2013 / 00:00 (54) 	Cycle 05 	BEFORE TREATMENT 	28 N NCS 	L1 (>5.172 mmol/L) 	4 	11 - 36 	
 	 	 	 	11JUL2013 / 00:00 (-8) 	Baseline 	BEFORE TREATMENT 	24 N NCS 	L1 (>1.5x ULN Enzyme U/L) 	 	11 - 36 	
 	 	 	 	14AUG2013 / 00:00 (27) 	Cycle 03 	BEFORE TREATMENT 	24 N NCS 	L1 (>10.8 10^9/L) 	0 	<11 - <36 	
 	 	 	 	14JAN2014 / 00:00 (180) 	End Of Treatment 	BEFORE TREATMENT 	24 N NCS 	L1 (<132 mmol/L) 	0 	<11 - <36 	
 	 	 	 	29AUG2013 / 00:00 (42) 	Cycle 04 	BEFORE TREATMENT 	26 N NCS 	L1 (>1.5x ULN Enzyme U/L) 	2 	11 - <36 	
 	 	 	Basophils Abs (10^9/L) 	04DEC2013 / 00:00 (139) 	Cycle 11 	BEFORE TREATMENT 	0.06 N CS 	L1 (>10.8 10^9/L) 	-1.46 	<0 - 0.2 	
 	 	 	 	06JAN2014 / 00:00 (172) 	Cycle 13 	BEFORE TREATMENT 	0.04 N NCS 	L1 (>1.694 mmol/L) 	-1.48 	<0 - <0.2 	
 	 	 	 	06NOV2013 / 00:00 (111) 	Cycle 09 	BEFORE TREATMENT 	0.05 N CS 	L3 (>6.5 mmol/L) 	-1.47 	<0 - 0.2 	
 	 	 	 	09OCT2013 / 00:00 (83) 	Cycle 07 	BEFORE TREATMENT 	0.07 N NCS 	L2 (>6.0 mmol/L) 	-1.45 	0 - <0.2 	
 	 	 	 	10SEP2013 / 00:00 (54) 	Cycle 05 	BEFORE TREATMENT 	0.04 N NCS 	L2 (>3.387 mmol/L) 	-1.48 	0 - 0.2 	
 	 	 	 	14AUG2013 / 00:00 (27) 	Cycle 03 	BEFORE TREATMENT 	0.04 N NCS 	L2 (>13.0 10^9/L) 	-1.48 	0 - 0.2 	
 	 	 	 	14JAN2014 / 00:00 (180) 	End Of Treatment 	BEFORE TREATMENT 	0.06 N NCS 	 	-1.46 	<0 - <0.2 	
 	 	 	 	29AUG2013 / 00:00 (42) 	Cycle 04 	BEFORE TREATMENT 	0.04 N NCS 	L2 (>3.387 mmol/L) 	-1.48 	0 - <0.2 	
 	 	 	Basophils/Leukocytes (FRACTION) 	01AUG2013 / 00:00 (14) 	Cycle 02 	BEFORE TREATMENT 	0.40 H CS 	L2 (>13.0 10^9/L) 	0.10 	<0 - 0.02 	
 	 	 	 	11JUL2013 / 00:00 (-8) 	Baseline 	BEFORE TREATMENT 	0.30 H NCS 	L2 (<1.996 mmol/L) 	 	0 - 0.02 	
 	 	 	Bilirubin (umol/L) 	01AUG2013 / 00:00 (14) 	Cycle 02 	BEFORE TREATMENT 	11.97 N CS 	L2 (>13.0 10^9/L) 	-6.84 	<3 - <21 	
 	 	 	 	04DEC2013 / 00:00 (139) 	Cycle 11 	BEFORE TREATMENT 	13.68 N NCS 	L1 (<132 mmol/L) 	-5.13 	<3 - 21 	
 	 	 	 	06JAN2014 / 00:00 (172) 	Cycle 13 	BEFORE TREATMENT 	15.39 N NCS 	L1 (>1.5x ULN Enzyme U/L) 	-3.42 	3 - <21 	
 	 	 	 	06NOV2013 / 00:00 (111) 	Cycle 09 	BEFORE TREATMENT 	11.97 N NCS 	L1 (>1.694 mmol/L) 	-6.84 	3 - 21 	
 	 	 	 	09OCT2013 / 00:00 (83) 	Cycle 07 	BEFORE TREATMENT 	13.68 N NCS 	L2 (fasting >=6.99 mmol/L or random >=11.10 mmol/L) 	-5.13 	<3 - 21 	
 	 	 	 	10SEP2013 / 00:00 (54) 	Cycle 05 	BEFORE TREATMENT 	13.68 N NCS 	L2 (>3.387 mmol/L) 	-5.13 	3 - 21 	
 	 	 	 	11JUL2013 / 00:00 (-8) 	Baseline 	BEFORE TREATMENT 	18.81 N NCS 	L2 (>6.206 mmol/L) 	 	<3 - 21 	
 	 	 	 	14AUG2013 / 00:00 (27) 	Cycle 03 	BEFORE TREATMENT 	13.68 N CS 	L1 (125-135 g/L) 	-5.13 	3 - <21 	
 	 	 	 	14JAN2014 / 00:00 (180) 	End Of Treatment 	BEFORE TREATMENT 	13.68 N CS 	L2 (>6.206 mmol/L) 	-5.13 	3 - <21 	
 	 	 	 	29AUG2013 / 00:00 (42) 	Cycle 04 	BEFORE TREATMENT 	11.97 N NCS 	L2 (>3.387 mmol/L) 	-6.84 	3 - <21 	
 	 	 	Calcium (mmol/L) 	01AUG2013 / 00:00 (14) 	Cycle 02 	BEFORE TREATMENT 	2.2205 N NCS 	L1 (>5.172 mmol/L) 	-0.0749 	2.1 - 2.57 	
 	 	 	 	04DEC2013 / 00:00 (139) 	Cycle 11 	BEFORE TREATMENT 	2.1207 N NCS 	L2 (>2.745 mmol/L) 	-0.1747 	<2.1 - 2.57 	
 	 	 	 	06JAN2014 / 00:00 (172) 	Cycle 13 	BEFORE TREATMENT 	2.0958 L NCS 	L1 (>5.172 mmol/L) 	-0.1996 	2.1 - 2.57 	
 	 	 	 	06NOV2013 / 00:00 (111) 	Cycle 09 	BEFORE TREATMENT 	1.9960 L NCS 	L2 (>6.206 mmol/L) 	-0.2994 	<2.1 - 2.57 	
 	 	 	 	09OCT2013 / 00:00 (83) 	Cycle 07 	BEFORE TREATMENT 	2.2205 N NCS 	L1 (>1.694 mmol/L) 	-0.0749 	<2.1 - 2.57 	
 	 	 	 	10SEP2013 / 00:00 (54) 	Cycle 05 	BEFORE TREATMENT 	2.1457 N CS 	 	-0.1497 	2.1 - <2.57 	
 	 	 	 	11JUL2013 / 00:00 (-8) 	Baseline 	BEFORE TREATMENT 	2.2954 N CS 	L1 (<132 mmol/L) 	 	2.1 - <2.57 	
 	 	 	 	14AUG2013 / 00:00 (27) 	Cycle 03 	BEFORE TREATMENT 	2.1706 N NCS 	L2 (<1.996 mmol/L) 	-0.1248 	2.1 - <2.57 	
 	 	 	 	14JAN2014 / 00:00 (180) 	End Of Treatment 	BEFORE TREATMENT 	2.2205 N CS 	L2 (<1.996 mmol/L) 	-0.0749 	<2.1 - 2.57 	
 	 	 	 	29AUG2013 / 00:00 (42) 	Cycle 04 	BEFORE TREATMENT 	2.1956 N NCS 	L2 (>2.745 mmol/L) 	-0.0998 	<2.1 - 2.57 	
 	 	 	Chloride (mmol/L) 	01AUG2013 / 00:00 (14) 	Cycle 02 	BEFORE TREATMENT 	103 N NCS 	L2 (>6.206 mmol/L) 	0 	<94 - 112 	
 	 	 	 	04DEC2013 / 00:00 (139) 	Cycle 11 	BEFORE TREATMENT 	105 N NCS 	L2 (>6.0 mmol/L) 	2 	<94 - 112 	
 	 	 	 	06JAN2014 / 00:00 (172) 	Cycle 13 	BEFORE TREATMENT 	107 N NCS 	L2 (>6.0 mmol/L) 	4 	<94 - 112 	
 	 	 	 	06NOV2013 / 00:00 (111) 	Cycle 09 	BEFORE TREATMENT 	108 N CS 	L1 (>5.172 mmol/L) 	5 	<94 - <112 	
 	 	 	 	09OCT2013 / 00:00 (83) 	Cycle 07 	BEFORE TREATMENT 	105 N NCS 	L1 (>5.172 mmol/L) 	2 	94 - <112 	
 	 	 	 	10SEP2013 / 00:00 (54) 	Cycle 05 	BEFORE TREATMENT 	105 N NCS 	L1 (125-135 g/L) 	2 	<94 - 112 	
 	 	 	 	11JUL2013 / 00:00 (-8) 	Baseline 	BEFORE TREATMENT 	103 N NCS 	L2 (>6.206 mmol/L) 	 	94 - <112 	
 	 	 	 	14AUG2013 / 00:00 (27) 	Cycle 03 	BEFORE TREATMENT 	111 N NCS 	L1 (<132 mmol/L) 	8 	<94 - <112 	
 	 	 	 	14JAN2014 / 00:00 (180) 	End Of Treatment 	BEFORE TREATMENT 	103 N NCS 	L1 (>5.172 mmol/L) 	0 	94 - <112 	
 	 	 	 	29AUG2013 / 00:00 (42) 	Cycle 04 	BEFORE TREATMENT 	107 N NCS 	L2 (>6.206 mmol/L) 	4 	94 - 112 	
 	 	 	Cholesterol (mmol/L) 	01AUG2013 / 00:00 (14) 	Cycle 02 	BEFORE TREATMENT 	4.7065 N NCS 	L2 (>6.206 mmol/L) 	-0.1034 	<3.85 - <7.4 	
 	 	 	 	04DEC2013 / 00:00 (139) 	Cycle 11 	BEFORE TREATMENT 	4.3962 N CS 	L1 (>1.5x ULN Enzyme U/L) 	-0.4138 	3.85 - 7.4 	
 	 	 	 	06JAN2014 / 00:00 (172) 	Cycle 13 	BEFORE TREATMENT 	4.2410 N NCS 	L2 (>3.387 mmol/L) 	-0.5689 	<3.85 - <7.4 	
 	 	 	 	06NOV2013 / 00:00 (111) 	Cycle 09 	BEFORE TREATMENT 	3.9307 N NCS 	L1 (125-135 g/L) 	-0.8792 	<3.85 - <7.4 	
 	 	 	 	09OCT2013 / 00:00 (83) 	Cycle 07 	BEFORE TREATMENT 	5.0686 N CS 	L2 (>6.0 mmol/L) 	0.2586 	3.85 - 7.4 	
 	 	 	 	10SEP2013 / 00:00 (54) 	Cycle 05 	BEFORE TREATMENT 	4.4221 N NCS 	L2 (>13.0 10^9/L) 	-0.3879 	3.85 - 7.4 	
 	 	 	 	11JUL2013 / 00:00 (-8) 	Baseline 	BEFORE TREATMENT 	4.8100 N NCS 	L1 (>1.694 mmol/L) 	 	3.85 - 7.4 	
 	 	 	 	14AUG2013 / 00:00 (27) 	Cycle 03 	BEFORE TREATMENT 	4.3703 N CS 	L2 (>3.387 mmol/L) 	-0.4396 	3.85 - 7.4 	
 	 	 	 	14JAN2014 / 00:00 (180) 	End Of Treatment 	BEFORE TREATMENT 	4.6807 N NCS 	L3 (>15.0 10^9/L) 	-0.1293 	3.85 - 7.4 	
 	 	 	 	29AUG2013 / 00:00 (42) 	Cycle 04 	BEFORE TREATMENT 	4.2669 N NCS 	L2 (<1.996 mmol/L) 	-0.5431 	<3.85 - 7.4 	
 	 	 	Color 	01AUG2013 / 00:00 (14) 	Cycle 02 	BEFORE TREATMENT 	 	L2 (>13.0 10^9/L) 	 	 	
 	 	 	 	06JAN2014 / 00:00 (172) 	Cycle 13 	BEFORE TREATMENT 	 	L1 (<132 mmol/L) 	 	 	
 	 	 	 	09OCT2013 / 00:00 (83) 	Cycle 07 	BEFORE TREATMENT 	 	L1 (>1.5x ULN Enzyme U/L) 	 	 	
 	 	 	 	11JUL2013 / 00:00 (-8) 	Baseline 	BEFORE TREATMENT 	 	L2 (fasting >=6.99 mmol/L or random >=11.10 mmol/L) 	 	 	
 	 	 	Creatinine (umol/L) 	01AUG2013 / 00:00 (14) 	Cycle 02 	BEFORE TREATMENT 	132.60 N NCS 	L1 (>1.694 mmol/L) 	8.84 	71 - <141 	
 	 	 	 	04DEC2013 / 00:00 (139) 	Cycle 11 	BEFORE TREATMENT 	123.76 N NCS 	L1 (>5.172 mmol/L) 	0.00 	71 - <141 	
 	 	 	 	06JAN2014 / 00:00 (172) 	Cycle 13 	BEFORE TREATMENT 	132.60 N NCS 	L1 (<132 mmol/L) 	8.84 	71 - <141 	
 	 	 	 	06NOV2013 / 00:00 (111) 	Cycle 09 	BEFORE TREATMENT 	114.92 N CS 	L2 (>6.206 mmol/L) 	-8.84 	71 - 141 	

Key: [CS=clinically significant] 	
Key: [CS=clinically significant]	
Key: [CS=clinically significant]	
Key: [CS=clinically significant]	
Key: [CS=clinically significant]	
Key: [CS=clinically significant]	
Key: [CS=clinically significant]	
Key: [CS=clinically significant]	
Key: [CS=clinically significant]	
Key: [CS=clinically significant]	
Key: [CS=clinically significant]	
a Study day is relative to [the start of [study treatment]]. 	a Study day is relative to [the start of [study treatment]].	a Study day is relative to [the start of [study treatment]].	a Study day is relative to [the start of [study treatment]].	a Study day is relative to [the start of [study treatment]].	a Study day is relative to [the start of [study treatment]].	a Study day is relative to [the start of [study treatment]].	a Study day is relative to [the start of [study treatment]].	a Study day is relative to [the start of [study treatment]].	a Study day is relative to [the start of [study treatment]].	a Study day is relative to [the start of [study treatment]].