LSIDEM01:	Listing of Demographics and Baseline Characteristics; Full Analysis Set (Study jjcs - core)											
Treatment Group 	Subject ID 	Region 	Country / Territory 	Informed Consent Date 	Age (years) / Sex / Race 	Ethnicity 	Weight (kg) 	Height (cm) 	BMI (kg/m2) 	BSA (m2) 	
Xanomeline High Dose 	01-701-1028 	NA 	United States of America 	11JUL2013 	71 / M / Asian 	Not Hispanic or Latino 	68.0 	103.0 	101.00 	72.00 	
 	01-701-1034 	NA 	United States of America 	24JUN2014 	77 / F / White 	Unknown 	75.0 	47.0 	142.00 	81.00 	
 	01-701-1133 	NA 	United States of America 	23OCT2012 	81 / F / Other 	Not Hispanic or Latino 	117.0 	76.0 	87.00 	90.00 	
 	01-701-1146 	NA 	United States of America 	07MAY2013 	75 / F / Unknown 	Not Hispanic or Latino 	119.0 	67.0 	134.00 	135.00 	
 	01-701-1148 	NA 	United States of America 	14AUG2013 	57 / M / Not reported 	Unknown 	10.0 	126.0 	14.00 	64.00 	
 	01-701-1180 	NA 	United States of America 	28JAN2013 	56 / M / American Indian or Alaska Native 	Not reported 	14.0 	8.0 	24.00 	66.00 	
 	01-701-1181 	NA 	United States of America 	26NOV2013 	79 / F / Not reported 	Unknown 	107.0 	36.0 	137.00 	31.00 	
 	01-701-1239 	NA 	United States of America 	28DEC2013 	56 / M / White 	Unknown 	119.0 	110.0 	54.00 	114.00 	
 	01-701-1275 	NA 	United States of America 	25JAN2014 	61 / M / White 	Not reported 	100.0 	118.0 	108.00 	37.00 	
 	01-701-1287 	NA 	United States of America 	17JAN2014 	56 / F / Multiple 	Unknown 	23.0 	71.0 	47.00 	29.00 	
 	01-701-1302 	NA 	United States of America 	20AUG2013 	61 / M / Asian 	Not Hispanic or Latino 	66.0 	64.0 	76.00 	115.00 	
 	01-701-1360 	NA 	United States of America 	24JUL2013 	67 / M / Multiple 	Unknown 	10.0 	38.0 	91.00 	96.00 	
 	01-701-1383 	NA 	United States of America 	22JAN2013 	72 / F / Native Hawaiian or other Pacific Islander 	Unknown 	73.0 	46.0 	62.00 	16.00 	
 	01-701-1444 	NA 	United States of America 	31DEC2012 	63 / M / American Indian or Alaska Native 	Unknown 	16.0 	125.0 	129.00 	26.00 	
 	01-703-1076 	NA 	United States of America 	17OCT2013 	69 / M / White 	Not Hispanic or Latino 	129.0 	32.0 	74.00 	135.00 	
 	01-703-1258 	NA 	United States of America 	10JUL2012 	78 / F / Black or African American 	Not Hispanic or Latino 	24.0 	143.0 	113.00 	48.00 	
 	01-703-1295 	NA 	United States of America 	24OCT2013 	88 / F / Other 	Not Hispanic or Latino 	111.0 	88.0 	139.00 	138.00 	
 	01-703-1335 	NA 	United States of America 	28FEB2014 	67 / F / Not reported 	Not Hispanic or Latino 	20.0 	45.0 	141.00 	97.00 	
 	01-703-1403 	NA 	United States of America 	05DEC2012 	67 / M / Multiple 	Unknown 	104.0 	118.0 	142.00 	13.00 	
 	01-703-1439 	NA 	United States of America 	04MAR2014 	76 / F / White 	Hispanic or Latino 	3.0 	23.0 	60.00 	87.00 	
 	01-704-1008 	NA 	United States of America 	06JAN2013 	76 / F / White 	Hispanic or Latino 	70.0 	4.0 	122.00 	36.00 	
 	01-704-1017 	NA 	United States of America 	20SEP2013 	77 / M / Asian 	Unknown 	123.0 	98.0 	33.00 	137.00 	
 	01-704-1065 	NA 	United States of America 	17OCT2013 	75 / M / Multiple 	Unknown 	74.0 	34.0 	58.00 	51.00 	
 	01-704-1074 	NA 	United States of America 	19JAN2014 	80 / F / Native Hawaiian or other Pacific Islander 	Not Hispanic or Latino 	59.0 	9.0 	29.00 	149.00 	
 	01-704-1093 	NA 	United States of America 	22FEB2013 	79 / M / American Indian or Alaska Native 	Hispanic or Latino 	84.0 	11.0 	143.00 	10.00 	
 	01-704-1241 	NA 	United States of America 	14AUG2013 	86 / M / Not reported 	Unknown 	7.0 	82.0 	57.00 	69.00 	
 	01-704-1266 	NA 	United States of America 	05OCT2013 	82 / M / Multiple 	Not reported 	122.0 	31.0 	61.00 	35.00 	
 	01-704-1332 	NA 	United States of America 	24NOV2013 	80 / M / Multiple 	Not reported 	16.0 	118.0 	21.00 	45.00 	
 	01-705-1280 	NA 	United States of America 	11JAN2014 	56 / F / Native Hawaiian or other Pacific Islander 	Unknown 	147.0 	6.0 	108.00 	80.00 	
 	01-705-1281 	NA 	United States of America 	26NOV2013 	73 / F / Not reported 	Not Hispanic or Latino 	90.0 	137.0 	38.00 	98.00 	
 	01-705-1303 	NA 	United States of America 	10DEC2013 	72 / M / Unknown 	Hispanic or Latino 	52.0 	48.0 	3.00 	30.00 	
 	01-705-1310 	NA 	United States of America 	26OCT2013 	74 / F / Native Hawaiian or other Pacific Islander 	Unknown 	62.0 	68.0 	9.00 	50.00 	
 	01-705-1377 	NA 	United States of America 	29DEC2013 	63 / F / Unknown 	Not Hispanic or Latino 	82.0 	75.0 	114.00 	16.00 	
 	01-705-1382 	NA 	United States of America 	09MAY2013 	82 / M / Multiple 	Not reported 	54.0 	137.0 	114.00 	114.00 	
 	01-706-1049 	NA 	United States of America 	30APR2013 	60 / F / Native Hawaiian or other Pacific Islander 	Not Hispanic or Latino 	91.0 	116.0 	129.00 	31.00 	
 	01-708-1178 	NA 	United States of America 	13DEC2013 	77 / F / Unknown 	Unknown 	123.0 	89.0 	4.00 	122.00 	
 	01-708-1213 	NA 	United States of America 	01FEB2013 	76 / F / Unknown 	Not Hispanic or Latino 	111.0 	34.0 	9.00 	31.00 	
 	01-708-1216 	NA 	United States of America 	14OCT2012 	78 / M / Asian 	Not Hispanic or Latino 	4.0 	53.0 	129.00 	86.00 	
 	01-708-1236 	NA 	United States of America 	08SEP2013 	86 / F / White 	Not Hispanic or Latino 	99.0 	72.0 	98.00 	84.00 	
 	01-708-1336 	NA 	United States of America 	21NOV2012 	73 / M / Other 	Unknown 	30.0 	88.0 	135.00 	88.00 	
 	01-708-1347 	NA 	United States of America 	11APR2013 	61 / F / White 	Hispanic or Latino 	45.0 	75.0 	104.00 	117.00 	
 	01-708-1372 	NA 	United States of America 	03APR2013 	84 / M / Not reported 	Not reported 	134.0 	10.0 	80.00 	122.00 	
 	01-708-1406 	NA 	United States of America 	06DEC2013 	71 / F / Not reported 	Not Hispanic or Latino 	64.0 	10.0 	135.00 	61.00 	
 	01-709-1029 	NA 	United States of America 	10DEC2012 	82 / M / Other 	Not reported 	138.0 	1.0 	139.00 	27.00 	
 	01-709-1099 	NA 	United States of America 	14OCT2013 	79 / F / Multiple 	Unknown 	138.0 	47.0 	137.00 	50.00 	
 	01-709-1168 	NA 	United States of America 	25JUL2013 	72 / F / American Indian or Alaska Native 	Not reported 	141.0 	28.0 	5.00 	76.00 	
 	01-709-1238 	NA 	United States of America 	02MAY2013 	69 / M / White 	Unknown 	92.0 	106.0 	100.00 	59.00 	
 	01-709-1309 	NA 	United States of America 	09JUN2013 	65 / M / American Indian or Alaska Native 	Unknown 	87.0 	59.0 	23.00 	21.00 	
 	01-709-1329 	NA 	United States of America 	01AUG2013 	70 / M / Native Hawaiian or other Pacific Islander 	Unknown 	41.0 	24.0 	73.00 	43.00 	
 	01-709-1424 	NA 	United States of America 	15FEB2013 	77 / M / Other 	Not Hispanic or Latino 	7.0 	18.0 	150.00 	99.00 	
 	01-710-1006 	NA 	United States of America 	27JAN2013 	77 / M / Asian 	Hispanic or Latino 	38.0 	10.0 	54.00 	122.00 	
 	01-710-1021 	NA 	United States of America 	19SEP2013 	79 / M / Native Hawaiian or other Pacific Islander 	Not reported 	95.0 	142.0 	85.00 	65.00 	
 	01-710-1070 	NA 	United States of America 	28AUG2012 	85 / F / Unknown 	Hispanic or Latino 	21.0 	104.0 	72.00 	55.00 	
 	01-710-1137 	NA 	United States of America 	03OCT2013 	79 / F / Multiple 	Hispanic or Latino 	63.0 	101.0 	59.00 	55.00 	
 	01-710-1142 	NA 	United States of America 	12SEP2012 	76 / F / Not reported 	Not Hispanic or Latino 	23.0 	88.0 	4.00 	25.00 	
 	01-710-1187 	NA 	United States of America 	26OCT2012 	78 / F / Unknown 	Hispanic or Latino 	85.0 	130.0 	67.00 	50.00 	
 	01-710-1249 	NA 	United States of America 	19DEC2013 	79 / M / Not reported 	Not Hispanic or Latino 	136.0 	61.0 	97.00 	84.00 	
 	01-710-1278 	NA 	United States of America 	13DEC2012 	81 / M / Asian 	Hispanic or Latino 	25.0 	119.0 	28.00 	76.00 	
 	01-710-1354 	NA 	United States of America 	29OCT2012 	73 / M / Black or African American 	Not Hispanic or Latino 	53.0 	140.0 	69.00 	36.00 	
 	01-710-1408 	NA 	United States of America 	26DEC2012 	80 / M / Multiple 	Not reported 	4.0 	30.0 	5.00 	35.00 	
 	01-711-1012 	NA 	United States of America 	20MAR2013 	67 / F / Native Hawaiian or other Pacific Islander 	Hispanic or Latino 	76.0 	90.0 	56.00 	67.00 	
 	01-711-1433 	NA 	United States of America 	23JAN2013 	84 / F / Asian 	Hispanic or Latino 	85.0 	33.0 	89.00 	29.00 	
 	01-713-1106 	NA 	United States of America 	03OCT2012 	74 / M / Not reported 	Not reported 	24.0 	66.0 	130.00 	150.00 	
 	01-713-1141 	NA 	United States of America 	23MAY2013 	79 / M / White 	Not reported 	93.0 	88.0 	60.00 	73.00 	
 	01-713-1209 	NA 	United States of America 	16MAY2013 	77 / F / Black or African American 	Not reported 	127.0 	132.0 	63.00 	131.00 	
 	01-714-1288 	NA 	United States of America 	24NOV2013 	77 / M / Multiple 	Not Hispanic or Latino 	109.0 	16.0 	11.00 	72.00 	
 	01-714-1425 	NA 	United States of America 	11AUG2013 	81 / M / Black or African American 	Unknown 	124.0 	13.0 	4.00 	81.00 	
 	01-715-1319 	NA 	United States of America 	03FEB2013 	65 / M / Multiple 	Unknown 	102.0 	103.0 	110.00 	60.00 	
 	01-715-1321 	NA 	United States of America 	06FEB2014 	75 / F / Native Hawaiian or other Pacific Islander 	Hispanic or Latino 	79.0 	32.0 	30.00 	61.00 	
 	01-716-1030 	NA 	United States of America 	25DEC2013 	83 / F / Black or African American 	Not Hispanic or Latino 	47.0 	13.0 	100.00 	71.00 	
 	01-716-1071 	NA 	United States of America 	03JUN2013 	78 / F / Black or African American 	Hispanic or Latino 	128.0 	20.0 	120.00 	6.00 	
 	01-716-1189 	NA 	United States of America 	07OCT2012 	81 / M / Asian 	Hispanic or Latino 	145.0 	119.0 	68.00 	141.00 	
 	01-716-1229 	NA 	United States of America 	14FEB2013 	73 / F / Asian 	Not Hispanic or Latino 	107.0 	29.0 	89.00 	73.00 	
 	01-716-1364 	NA 	United States of America 	27JUN2013 	84 / F / Unknown 	Not reported 	10.0 	69.0 	45.00 	96.00 	
 	01-716-1373 	NA 	United States of America 	24NOV2012 	74 / M / American Indian or Alaska Native 	Unknown 	50.0 	41.0 	76.00 	87.00 	
 	01-716-1418 	NA 	United States of America 	27APR2013 	80 / F / Native Hawaiian or other Pacific Islander 	Hispanic or Latino 	15.0 	19.0 	125.00 	145.00 	
 	01-716-1447 	NA 	United States of America 	10DEC2013 	72 / F / Unknown 	Hispanic or Latino 	10.0 	39.0 	147.00 	15.00 	
 	01-717-1109 	NA 	United States of America 	20JAN2014 	84 / M / Asian 	Not reported 	100.0 	57.0 	110.00 	97.00 	
 	01-717-1174 	NA 	United States of America 	16JAN2013 	73 / M / American Indian or Alaska Native 	Not Hispanic or Latino 	149.0 	82.0 	135.00 	91.00 	
 	01-717-1357 	NA 	United States of America 	21APR2013 	77 / M / White 	Not Hispanic or Latino 	114.0 	75.0 	20.00 	70.00 	
 	01-718-1101 	NA 	United States of America 	01FEB2013 	82 / M / Asian 	Not Hispanic or Latino 	90.0 	19.0 	60.00 	22.00 	
 	01-718-1328 	NA 	United States of America 	28JAN2013 	86 / M / Not reported 	Hispanic or Latino 	68.0 	58.0 	131.00 	16.00 	
 	01-718-1371 	NA 	United States of America 	11APR2013 	69 / F / Unknown 	Hispanic or Latino 	22.0 	136.0 	1.00 	85.00 	
 	01-718-1427 	NA 	United States of America 	13DEC2012 	74 / F / Black or African American 	Hispanic or Latino 	20.0 	30.0 	134.00 	24.00 	
Xanomeline Low Dose 	01-701-1033 	NA 	United States of America 	10MAR2014 	74 / M / Multiple 	Not reported 	63.0 	31.0 	14.00 	48.00 	
 	01-701-1097 	NA 	United States of America 	23DEC2013 	68 / M / Other 	Unknown 	17.0 	34.0 	4.00 	107.00 	
 	01-701-1111 	NA 	United States of America 	25AUG2012 	81 / F / White 	Not reported 	3.0 	54.0 	80.00 	92.00 	
 	01-701-1115 	NA 	United States of America 	23NOV2012 	84 / M / Black or African American 	Not Hispanic or Latino 	105.0 	124.0 	129.00 	52.00 	
 	01-701-1188 	NA 	United States of America 	03FEB2013 	71 / M / White 	Not reported 	88.0 	53.0 	27.00 	52.00 	
 	01-701-1192 	NA 	United States of America 	08JUL2012 	80 / F / Not reported 	Not Hispanic or Latino 	35.0 	23.0 	133.00 	22.00 	
 	01-701-1211 	NA 	United States of America 	30OCT2012 	76 / F / Other 	Hispanic or Latino 	6.0 	108.0 	146.00 	57.00 	
 	01-701-1294 	NA 	United States of America 	17MAR2013 	67 / M / Other 	Hispanic or Latino 	67.0 	13.0 	129.00 	131.00 	
 	01-701-1317 	NA 	United States of America 	10MAY2014 	68 / M / Unknown 	Unknown 	73.0 	25.0 	82.00 	38.00 	
 	01-701-1324 	NA 	United States of America 	16SEP2012 	79 / M / Asian 	Unknown 	92.0 	45.0 	30.00 	95.00 	
 	01-701-1341 	NA 	United States of America 	22DEC2012 	51 / M / American Indian or Alaska Native 	Not reported 	132.0 	22.0 	107.00 	125.00 	
 	01-701-1429 	NA 	United States of America 	25FEB2013 	84 / F / American Indian or Alaska Native 	Hispanic or Latino 	71.0 	144.0 	103.00 	86.00 	
 	01-701-1442 	NA 	United States of America 	17OCT2013 	57 / F / Asian 	Unknown 	134.0 	108.0 	39.00 	45.00 	
 	01-702-1082 	NA 	United States of America 	03JUL2013 	84 / F / Asian 	Not Hispanic or Latino 	127.0 	109.0 	109.00 	139.00 	
 	01-703-1086 	NA 	United States of America 	22AUG2012 	71 / M / Multiple 	Unknown 	78.0 	79.0 	129.00 	85.00 	
 	01-703-1119 	NA 	United States of America 	02FEB2013 	81 / F / Native Hawaiian or other Pacific Islander 	Hispanic or Latino 	69.0 	132.0 	120.00 	121.00