LSIMH01:	Listing of [Medical History/Medical History of Interest]; Full Analysis Set (Study jjcs - core)									
Treatment Group 	Subject ID 	Age (years) / Sex / Race 	System Organ Class 	[Preferred Term / Reported Term] 	Start Date (Study Day)a 	End Date (Study Day)a 	Ongoing? 	Toxicity Grade 	
Xanomeline High Dose 	01-701-1028 	71 / M / Asian 	SURGICAL AND MEDICAL PROCEDURES 	APPENDICECTOMY / VERBATIM_1775 	1968 	 	 	5 	
 	 	 	SURGICAL AND MEDICAL PROCEDURES 	LIPECTOMY / VERBATIM_1006 	1981 	 	 	2 	
 	 	 	 	 / ALZHEIMER'S DISEASE 	16DEC2009 (-1311) 	24NOV2010 (-968) 	No 	1 	
 	 	 	EYE DISORDERS 	PRESBYOPIA / VERBATIM_0507 	 	 	 	1 	
 	 	 	MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS 	ARTHRITIS / VERBATIM_1686 	 	 	 	3 	
 	 	 	NEOPLASMS BENIGN, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS) 	LIPOMA / VERBATIM_0428 	 	 	 	5 	
 	01-701-1034 	77 / F / White 	SURGICAL AND MEDICAL PROCEDURES 	TONSILLECTOMY / VERBATIM_1716 	1946 	 	 	4 	
 	 	 	SURGICAL AND MEDICAL PROCEDURES 	APPENDICECTOMY / VERBATIM_1775 	1949 	 	 	5 	
 	 	 	SURGICAL AND MEDICAL PROCEDURES 	HYSTERECTOMY / VERBATIM_0936 	1960 	 	 	2 	
 	 	 	GASTROINTESTINAL DISORDERS 	ANAL FISTULA / VERBATIM_1133 	1962 	 	 	4 	
 	 	 	INJURY, POISONING AND PROCEDURAL COMPLICATIONS 	FOOT FRACTURE / VERBATIM_1132 	2004 	 	 	3 	
 	 	 	SURGICAL AND MEDICAL PROCEDURES 	FACE LIFT / VERBATIM_1162 	21AUG2011 (-1045) 	29MAR2012 (-824) 	No 	 	
 	 	 	 	 / ALZHEIMER'S DISEASE 	29SEP2011 (-1006) 	03MAY2012 (-789) 	No 	4 	
 	 	 	INJURY, POISONING AND PROCEDURAL COMPLICATIONS 	LOWER LIMB FRACTURE / VERBATIM_0122 	2012 	 	 	5 	
 	 	 	MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS 	MUSCLE SPASMS / VERBATIM_0973 	21DEC2013 (-192) 	19JAN2014 (-163) 	No 	 	
 	 	 	INVESTIGATIONS 	BLOOD PRESSURE INCREASED / VERBATIM_1680 	11JUN2014 (-20) 	11APR2015 (285) 	Yes 	1 	
 	 	 	ENDOCRINE DISORDERS 	HYPOTHYROIDISM / VERBATIM_0692 	 	 	 	3 	
 	 	 	EYE DISORDERS 	HYPERMETROPIA / VERBATIM_1683 	 	 	 	2 	
 	 	 	GASTROINTESTINAL DISORDERS 	ABDOMINAL PAIN / VERBATIM_1385 	 	 	 	5 	
 	 	 	GASTROINTESTINAL DISORDERS 	CONSTIPATION / VERBATIM_0443 	 	 	 	 	
 	 	 	MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS 	ARTHRITIS / VERBATIM_0753 	 	 	 	1 	
 	 	 	MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS 	ARTHRITIS / VERBATIM_0763 	 	 	 	1 	
 	01-701-1133 	81 / F / Other 	SURGICAL AND MEDICAL PROCEDURES 	TONSILLECTOMY / VERBATIM_1716 	1939 	 	 	2 	
 	 	 	INVESTIGATIONS 	WEIGHT DECREASED / VERBATIM_0293 	1966 	 	 	 	
 	 	 	GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS 	CHEST PAIN / VERBATIM_0517 	1986 	 	 	1 	
 	 	 	VASCULAR DISORDERS 	HYPERTENSION / VERBATIM_0342 	1986 	 	 	1 	
 	 	 	GASTROINTESTINAL DISORDERS 	DIVERTICULUM / VERBATIM_1023 	2000 	 	 	1 	
 	 	 	GASTROINTESTINAL DISORDERS 	HAEMORRHOIDS / VERBATIM_0267 	2003 	 	 	5 	
 	 	 	SURGICAL AND MEDICAL PROCEDURES 	KNEE ARTHROPLASTY / VERBATIM_0009 	DEC2009 	 	 	1 	
 	 	 	 	 / ALZHEIMER'S DISEASE 	11MAR2010 (-962) 	01DEC2010 (-697) 	No 	2 	
 	 	 	EYE DISORDERS 	HYPERMETROPIA / VERBATIM_1683 	 	 	 	2 	
 	 	 	MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS 	POLYARTHRITIS / VERBATIM_1121 	 	 	 	1 	
 	 	 	SOCIAL CIRCUMSTANCES 	DENTURE WEARER / VERBATIM_1796 	 	 	 	4 	
 	01-701-1146 	75 / F / Unknown 	SURGICAL AND MEDICAL PROCEDURES 	TONSILLECTOMY / VERBATIM_1716 	1942 	 	 	5 	
 	 	 	RENAL AND URINARY DISORDERS 	BLADDER PROLAPSE / VERBATIM_0815 	2006 	 	 	1 	
 	 	 	 	 / ALZHEIMER'S DISEASE 	17NOV2009 (-1280) 	23MAR2010 (-1154) 	No 	5 	
 	 	 	GASTROINTESTINAL DISORDERS 	OESOPHAGEAL SPASM / VERBATIM_1117 	2011 	 	 	4 	
 	 	 	RENAL AND URINARY DISORDERS 	BLADDER PROLAPSE / VERBATIM_0815 	2012 	 	 	4 	
 	 	 	GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS 	CHEST PAIN / VERBATIM_0517 	27MAR2012 (-419) 	04AUG2012 (-289) 	No 	1 	
 	 	 	GASTROINTESTINAL DISORDERS 	ABDOMINAL DISCOMFORT / VERBATIM_0821 	06JUL2012 (-318) 	05APR2013 (-45) 	No 	3 	
 	 	 	SURGICAL AND MEDICAL PROCEDURES 	ENDODONTIC PROCEDURE / VERBATIM_1066 	12SEP2012 (-250) 	12APR2013 (-38) 	No 	1 	
 	 	 	INFECTIONS AND INFESTATIONS 	CYSTITIS / VERBATIM_0361 	27OCT2012 (-205) 	20FEB2013 (-89) 	No 	3 	
 	 	 	EAR AND LABYRINTH DISORDERS 	DEAFNESS / VERBATIM_0391 	 	 	 	5 	
 	 	 	GASTROINTESTINAL DISORDERS 	CONSTIPATION / VERBATIM_0443 	 	 	 	4 	
 	 	 	GASTROINTESTINAL DISORDERS 	DIARRHOEA / VERBATIM_1126 	 	 	 	3 	
 	 	 	INFECTIONS AND INFESTATIONS 	SINUSITIS / VERBATIM_1769 	 	 	 	1 	
 	 	 	INVESTIGATIONS 	CARDIAC MURMUR / VERBATIM_1223 	 	 	 	5 	
 	 	 	MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS 	ARTHRALGIA / VERBATIM_1441 	 	 	 	 	
 	 	 	MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS 	POLYARTHRITIS / VERBATIM_0325 	 	 	 	5 	
 	 	 	PSYCHIATRIC DISORDERS 	DEPRESSION / VERBATIM_1376 	 	 	 	4 	
 	01-701-1148 	57 / M / Not reported 	INJURY, POISONING AND PROCEDURAL COMPLICATIONS 	ANKLE FRACTURE / VERBATIM_0146 	1985 	 	 	1 	
 	 	 	GASTROINTESTINAL DISORDERS 	ANAL FISTULA / VERBATIM_0598 	1989 	 	 	4 	
 	 	 	SURGICAL AND MEDICAL PROCEDURES 	BREAST LUMP REMOVAL / VERBATIM_0305 	1991 	 	 	4 	
 	 	 	INJURY, POISONING AND PROCEDURAL COMPLICATIONS 	THERMAL BURN / VERBATIM_0036 	1996 	 	 	5 	
 	 	 	SURGICAL AND MEDICAL PROCEDURES 	SKIN GRAFT / VERBATIM_1550 	1996 	 	 	2 	
 	 	 	GASTROINTESTINAL DISORDERS 	ANAL FISTULA / VERBATIM_0598 	2007 	 	 	2 	
 	 	 	SURGICAL AND MEDICAL PROCEDURES 	SINUS OPERATION / VERBATIM_0807 	2010 	 	 	3 	
 	 	 	 	 / ALZHEIMER'S DISEASE 	12DEC2010 (-985) 	13OCT2011 (-680) 	No 	1 	
 	 	 	SKIN AND SUBCUTANEOUS TISSUE DISORDERS 	ACTINIC KERATOSIS / VERBATIM_1160 	2011 	 	 	5 	
 	 	 	CARDIAC DISORDERS 	PALPITATIONS / VERBATIM_0266 	 	 	 	4 	
 	 	 	EAR AND LABYRINTH DISORDERS 	DEAFNESS BILATERAL / VERBATIM_0978 	 	 	 	1 	
 	 	 	EAR AND LABYRINTH DISORDERS 	TINNITUS / VERBATIM_0047 	 	 	 	3 	
 	 	 	EYE DISORDERS 	ASTIGMATISM / VERBATIM_1751 	 	 	 	4 	
 	 	 	GASTROINTESTINAL DISORDERS 	DYSPEPSIA / VERBATIM_0800 	 	 	 	5 	
 	 	 	IMMUNE SYSTEM DISORDERS 	SEASONAL ALLERGY / VERBATIM_0396 	 	 	 	2 	
 	 	 	INFECTIONS AND INFESTATIONS 	SINUSITIS / VERBATIM_1769 	 	 	 	5 	
 	 	 	MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS 	BACK PAIN / VERBATIM_1583 	 	 	 	1 	
 	 	 	MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS 	MYALGIA / VERBATIM_0461 	 	 	 	3 	
 	 	 	MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS 	MYALGIA / VERBATIM_1073 	 	 	 	3 	
 	 	 	MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS 	POLYARTHRITIS / VERBATIM_1168 	 	 	 	5 	
 	 	 	NERVOUS SYSTEM DISORDERS 	DIZZINESS / VERBATIM_0982 	 	 	 	2 	
 	 	 	NERVOUS SYSTEM DISORDERS 	DIZZINESS / VERBATIM_1533 	 	 	 	2 	
 	 	 	NERVOUS SYSTEM DISORDERS 	HEADACHE / VERBATIM_0301 	 	 	 	3 	
 	 	 	NERVOUS SYSTEM DISORDERS 	HYPOAESTHESIA / VERBATIM_0383 	 	 	 	 	
 	 	 	NERVOUS SYSTEM DISORDERS 	HYPOAESTHESIA / VERBATIM_0617 	 	 	 	5 	
 	 	 	NERVOUS SYSTEM DISORDERS 	HYPOAESTHESIA / VERBATIM_1576 	 	 	 	 	
 	 	 	NERVOUS SYSTEM DISORDERS 	NEURALGIA / VERBATIM_0453 	 	 	 	4 	
 	 	 	NERVOUS SYSTEM DISORDERS 	NEURALGIA / VERBATIM_1213 	 	 	 	4 	
 	 	 	PSYCHIATRIC DISORDERS 	DEPRESSED MOOD / VERBATIM_0591 	 	 	 	5 	
 	 	 	RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS 	DYSPNOEA / VERBATIM_1509 	 	 	 	 	
 	01-701-1180 	56 / M / American Indian or Alaska Native 	 	 / ALZHEIMER'S DISEASE 	21SEP2008 (-1605) 	25MAR2009 (-1420) 	No 	3 	
 	 	 	NERVOUS SYSTEM DISORDERS 	HEADACHE / VERBATIM_0929 	 	 	 	3 	
 	01-701-1181 	79 / F / Not reported 	SURGICAL AND MEDICAL PROCEDURES 	TONSILLECTOMY / VERBATIM_1716 	1940 	 	 	3 	
 	 	 	SURGICAL AND MEDICAL PROCEDURES 	HYSTERECTOMY / VERBATIM_0167 	1967 	 	 	 	
 	 	 	SURGICAL AND MEDICAL PROCEDURES 	TOOTH EXTRACTION / VERBATIM_0204 	1980 	 	 	2 	
 	 	 	INFECTIONS AND INFESTATIONS 	PNEUMONIA PRIMARY ATYPICAL / VERBATIM_0124 	1989 	 	 	3 	
 	 	 	INJURY, POISONING AND PROCEDURAL COMPLICATIONS 	HEAD INJURY / VERBATIM_1143 	2006 	 	 	4 	
 	 	 	INJURY, POISONING AND PROCEDURAL COMPLICATIONS 	JOINT INJURY / VERBATIM_0192 	2006 	 	 	2 	
 	 	 	 	 / ALZHEIMER'S DISEASE 	26AUG2008 (-1927) 	26JAN2009 (-1774) 	No 	4 	
 	 	 	INFECTIONS AND INFESTATIONS 	BRONCHITIS / VERBATIM_1176 	2009 	 	 	3 	
 	 	 	RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS 	COUGH / VERBATIM_0303 	08JUN2012 (-545) 	03NOV2012 (-397) 	No 	1 	
 	 	 	EAR AND LABYRINTH DISORDERS 	DEAFNESS BILATERAL / VERBATIM_0978 	 	 	 	2 	
 	 	 	EYE DISORDERS 	PRESBYOPIA / VERBATIM_0507 	 	 	 	1 	
 	 	 	GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS 	OEDEMA PERIPHERAL / VERBATIM_0640 	 	 	 	2 	
 	 	 	INJURY, POISONING AND PROCEDURAL COMPLICATIONS 	PAIN TRAUMA ACTIVATED / VERBATIM_0048 	 	 	 	2 	
 	 	 	INJURY, POISONING AND PROCEDURAL COMPLICATIONS 	PAIN TRAUMA ACTIVATED / VERBATIM_0062 	 	 	 	5 	
 	 	 	INJURY, POISONING AND PROCEDURAL COMPLICATIONS 	SKELETAL INJURY / VERBATIM_1215 	 	 	 	3 	
 	 	 	MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS 	ARTHRALGIA / VERBATIM_0733 	 	 	 	 	
 	 	 	MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS 	ARTHRALGIA / VERBATIM_1327 	 	 	 	2 	
 	 	 	MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS 	FINGER DEFORMITY / VERBATIM_0966 	 	 	 	1 	

a Study day is relative to [the start of [study treatment]]. 	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
Note: Medical history is coded using MedDRA version 26.0. 	: Medical history is coded using MedDRA version 26.	: Medical history is coded using MedDRA version 26.	: Medical history is coded using MedDRA version 26.	: Medical history is coded using MedDRA version 26.	: Medical history is coded using MedDRA version 26.	: Medical history is coded using MedDRA version 26.	: Medical history is coded using MedDRA version 26.	: Medical history is coded using MedDRA version 26.	
Note: Medical history is evaluated according to the NCI-CTCAE version 5.0.. 	: Medical history is evaluated according to the NCI-CTCAE version 5..	: Medical history is evaluated according to the NCI-CTCAE version 5..	: Medical history is evaluated according to the NCI-CTCAE version 5..	: Medical history is evaluated according to the NCI-CTCAE version 5..	: Medical history is evaluated according to the NCI-CTCAE version 5..	: Medical history is evaluated according to the NCI-CTCAE version 5..	: Medical history is evaluated according to the NCI-CTCAE version 5..	: Medical history is evaluated according to the NCI-CTCAE version 5..