LSIDS01:	Listing of Subjects Who Permanently Discontinued Treatment;  Analysis Set (Study jjcs - core)									
Treatment Group 	Subject ID 	Age (years) / Sex / Race 	Study Agent Discontinued 	Last Visita 	Study Dayb of Last Study Agent Administered 	Total Dose (unit)c 	Date of Discontinuation 	Primary Reason for Discontinuation 	
Xanomeline High Dose 	01-701-1146 	75 / F / Unknown 	Treatment 	Last Treatment Visit 	400 	682 [unit] 	30JUN2013 	Other 	
 	01-701-1180 	56 / M / American Indian or Alaska Native 	Treatment 	Last Treatment Visit 	50 	678 [unit] 	23MAR2013 	Other 	
 	01-701-1181 	79 / F / Not reported 	Treatment 	Last Treatment Visit 	200 	3375 [unit] 	12DEC2013 	Other 	
 	01-701-1302 	61 / M / Asian 	Treatment 	Last Treatment Visit 	400 	1285 [unit] 	05NOV2013 	Other 	
 	01-701-1360 	67 / M / Multiple 	Treatment 	Last Treatment Visit 	50 	3744 [unit] 	14AUG2013 	Other 	
 	01-701-1444 	63 / M / American Indian or Alaska Native 	Treatment 	Last Treatment Visit 	100 	3217 [unit] 	13FEB2013 	Other 	
 	01-703-1076 	69 / M / White 	Treatment 	Last Treatment Visit 	50 	4866 [unit] 	24DEC2013 	Other 	
 	01-703-1258 	78 / F / Black or African American 	Treatment 	Last Treatment Visit 	300 	4920 [unit] 	21JAN2013 	Other 	
 	01-703-1295 	88 / F / Other 	Treatment 	Last Treatment Visit 	200 	4285 [unit] 	19MAY2014 	Other 	
 	01-703-1335 	67 / F / Not reported 	Treatment 	Last Treatment Visit 	300 	4144 [unit] 	24MAY2014 	Other 	
 	01-703-1403 	67 / M / Multiple 	Treatment 	Last Treatment Visit 	200 	4799 [unit] 	19DEC2012 	Other 	
 	01-704-1017 	77 / M / Asian 	Treatment 	Last Treatment Visit 	200 	1561 [unit] 	24NOV2013 	Other 	
 	01-704-1065 	75 / M / Multiple 	Treatment 	Last Treatment Visit 	300 	4487 [unit] 	24DEC2013 	Other 	
 	01-704-1093 	79 / M / American Indian or Alaska Native 	Treatment 	Last Treatment Visit 	400 	1035 [unit] 	20JUN2013 	Other 	
 	01-704-1241 	86 / M / Not reported 	Treatment 	Last Treatment Visit 	400 	2698 [unit] 	31OCT2013 	Other 	
 	01-704-1266 	82 / M / Multiple 	Treatment 	Last Treatment Visit 	300 	3347 [unit] 	06DEC2013 	Other 	
 	01-704-1332 	80 / M / Multiple 	Treatment 	Last Treatment Visit 	200 	3812 [unit] 	16FEB2014 	Other 	
 	01-705-1281 	73 / F / Not reported 	Treatment 	Last Treatment Visit 	300 	4016 [unit] 	17MAR2014 	Other 	
 	01-705-1303 	72 / M / Unknown 	Treatment 	Last Treatment Visit 	200 	4880 [unit] 	02JUN2014 	Other 	
 	01-705-1310 	74 / F / Native Hawaiian or other Pacific Islander 	Treatment 	Last Treatment Visit 	50 	2580 [unit] 	23JAN2014 	Other 	
 	01-705-1377 	63 / F / Unknown 	Treatment 	Last Treatment Visit 	100 	2996 [unit] 	07MAR2014 	Other 	
 	01-706-1049 	60 / F / Native Hawaiian or other Pacific Islander 	Treatment 	Last Treatment Visit 	200 	2178 [unit] 	25JUN2013 	Other 	
 	01-708-1178 	77 / F / Unknown 	Treatment 	Last Treatment Visit 	50 	261 [unit] 	06APR2014 	Other 	
 	01-708-1216 	78 / M / Asian 	Treatment 	Last Treatment Visit 	100 	4138 [unit] 	06DEC2012 	Other 	
 	01-708-1236 	86 / F / White 	Treatment 	Last Treatment Visit 	300 	3262 [unit] 	26SEP2013 	Other 	
 	01-708-1372 	84 / M / Not reported 	Treatment 	Last Treatment Visit 	400 	1322 [unit] 	10MAY2013 	Other 	
 	01-709-1168 	72 / F / American Indian or Alaska Native 	Treatment 	Last Treatment Visit 	50 	572 [unit] 	27SEP2013 	Other 	
 	01-709-1238 	69 / M / White 	Treatment 	Last Treatment Visit 	400 	2329 [unit] 	07AUG2013 	Other 	
 	01-709-1329 	70 / M / Native Hawaiian or other Pacific Islander 	Treatment 	Last Treatment Visit 	300 	756 [unit] 	29AUG2013 	Other 	
 	01-709-1424 	77 / M / Other 	Treatment 	Last Treatment Visit 	100 	3553 [unit] 	08MAR2013 	Other 	
 	01-710-1021 	79 / M / Native Hawaiian or other Pacific Islander 	Treatment 	Last Treatment Visit 	300 	1225 [unit] 	12NOV2013 	Other 	
 	01-710-1070 	85 / F / Unknown 	Treatment 	Last Treatment Visit 	100 	2619 [unit] 	23FEB2013 	Other 	
 	01-710-1137 	79 / F / Multiple 	Treatment 	Last Treatment Visit 	300 	4505 [unit] 	13NOV2013 	Other 	
 	01-710-1142 	76 / F / Not reported 	Treatment 	Last Treatment Visit 	100 	1884 [unit] 	23OCT2012 	Other 	
 	01-710-1278 	81 / M / Asian 	Treatment 	Last Treatment Visit 	300 	1435 [unit] 	03MAR2013 	Other 	
 	01-711-1012 	67 / F / Native Hawaiian or other Pacific Islander 	Treatment 	Last Treatment Visit 	50 	1873 [unit] 	02MAY2013 	Other 	
 	01-711-1433 	84 / F / Asian 	Treatment 	Last Treatment Visit 	400 	2045 [unit] 	06FEB2013 	Other 	
 	01-713-1141 	79 / M / White 	Treatment 	Last Treatment Visit 	400 	2384 [unit] 	06AUG2013 	Other 	
 	01-714-1425 	81 / M / Black or African American 	Treatment 	Last Treatment Visit 	50 	3686 [unit] 	22AUG2013 	Other 	
 	01-715-1319 	65 / M / Multiple 	Treatment 	Last Treatment Visit 	300 	3797 [unit] 	18MAR2013 	Other 	
 	01-715-1321 	75 / F / Native Hawaiian or other Pacific Islander 	Treatment 	Last Treatment Visit 	400 	1625 [unit] 	22APR2014 	Other 	
 	01-716-1071 	78 / F / Black or African American 	Treatment 	Last Treatment Visit 	300 	4590 [unit] 	01AUG2013 	Other 	
 	01-716-1229 	73 / F / Asian 	Treatment 	Last Treatment Visit 	200 	3984 [unit] 	02APR2013 	Other 	
 	01-716-1373 	74 / M / American Indian or Alaska Native 	Treatment 	Last Treatment Visit 	400 	3481 [unit] 	28FEB2013 	Other 	
 	01-717-1357 	77 / M / White 	Treatment 	Last Treatment Visit 	100 	3353 [unit] 	20OCT2013 	Other 	
 	01-718-1101 	82 / M / Asian 	Treatment 	Last Treatment Visit 	100 	4406 [unit] 	02AUG2013 	Other 	
 	01-718-1328 	86 / M / Not reported 	Treatment 	Last Treatment Visit 	100 	3352 [unit] 	01MAY2013 	Other 	
 	01-718-1371 	69 / F / Unknown 	Treatment 	Last Treatment Visit 	400 	3454 [unit] 	08AUG2013 	Other 	
 	01-718-1427 	74 / F / Black or African American 	Treatment 	Last Treatment Visit 	200 	1061 [unit] 	18FEB2013 	Other 	
Xanomeline Low Dose 	01-701-1033 	74 / M / Multiple 	Treatment 	Last Treatment Visit 	50 	2167 [unit] 	14APR2014 	Other 	
 	01-701-1115 	84 / M / Black or African American 	Treatment 	Last Treatment Visit 	400 	3252 [unit] 	23JAN2013 	Other 	
 	01-701-1188 	71 / M / White 	Treatment 	Last Treatment Visit 	100 	933 [unit] 	25MAR2013 	Other 	
 	01-701-1211 	76 / F / Other 	Treatment 	Last Treatment Visit 	50 	4245 [unit] 	14JAN2013 	Other 	
 	01-701-1429 	84 / F / American Indian or Alaska Native 	Treatment 	Last Treatment Visit 	50 	2949 [unit] 	30APR2013 	Other 	
 	01-703-1086 	71 / M / Multiple 	Treatment 	Last Treatment Visit 	200 	2829 [unit] 	24DEC2012 	Other 	
 	01-703-1119 	81 / F / Native Hawaiian or other Pacific Islander 	Treatment 	Last Treatment Visit 	300 	2288 [unit] 	13JUN2013 	Other 	
 	01-703-1182 	84 / M / Other 	Treatment 	Last Treatment Visit 	300 	2075 [unit] 	12DEC2013 	Other 	
 	01-703-1197 	76 / F / Other 	Treatment 	Last Treatment Visit 	300 	1716 [unit] 	22JUL2013 	Other 	
 	01-703-1279 	72 / F / Unknown 	Treatment 	Last Treatment Visit 	50 	3288 [unit] 	22JUN2013 	Other 	
 	01-704-1025 	81 / F / Asian 	Treatment 	Last Treatment Visit 	200 	958 [unit] 	29NOV2013 	Other 	
 	01-704-1114 	77 / M / Multiple 	Treatment 	Last Treatment Visit 	50 	967 [unit] 	08JUL2013 	Other 	
 	01-704-1120 	71 / F / Black or African American 	Treatment 	Last Treatment Visit 	50 	4345 [unit] 	03FEB2014 	Other 	
 	01-704-1323 	68 / F / Not reported 	Treatment 	Last Treatment Visit 	100 	1091 [unit] 	08AUG2013 	Other 	
 	01-704-1325 	81 / M / White 	Treatment 	Last Treatment Visit 	300 	4663 [unit] 	06AUG2014 	Other 	
 	01-705-1199 	87 / M / Black or African American 	Treatment 	Last Treatment Visit 	50 	493 [unit] 	29SEP2013 	Other 	
 	01-705-1393 	84 / F / Native Hawaiian or other Pacific Islander 	Treatment 	Last Treatment Visit 	300 	3762 [unit] 	20FEB2013 	Other 	
 	01-707-1037 	72 / F / American Indian or Alaska Native 	Treatment 	Last Treatment Visit 	50 	1543 [unit] 	08JAN2014 	Other 	
 	01-708-1019 	68 / M / Asian 	Treatment 	Last Treatment Visit 	400 	1177 [unit] 	23JAN2014 	Other 	
 	01-708-1272 	82 / M / Not reported 	Treatment 	Last Treatment Visit 	200 	201 [unit] 	04APR2013 	Other 	
 	01-708-1297 	61 / M / Not reported 	Treatment 	Last Treatment Visit 	300 	3732 [unit] 	08MAY2013 	Other 	
 	01-708-1428 	84 / F / Native Hawaiian or other Pacific Islander 	Treatment 	Last Treatment Visit 	200 	2365 [unit] 	31JAN2014 	Other 	
 	01-709-1007 	54 / F / Other 	Treatment 	Last Treatment Visit 	100 	3261 [unit] 	01SEP2012 	Other 	
 	01-709-1081 	86 / F / White 	Treatment 	Last Treatment Visit 	100 	4439 [unit] 	10MAY2014 	Other 	
 	01-709-1102 	71 / F / American Indian or Alaska Native 	Treatment 	Last Treatment Visit 	100 	250 [unit] 	31MAR2013 	Other 	
 	01-709-1217 	77 / M / American Indian or Alaska Native 	Treatment 	Last Treatment Visit 	400 	3360 [unit] 	25JUN2013 	Other 	
 	01-709-1285 	87 / M / Native Hawaiian or other Pacific Islander 	Treatment 	Last Treatment Visit 	100 	3992 [unit] 	31MAY2013 	Other 	
 	01-710-1002 	88 / M / American Indian or Alaska Native 	Treatment 	Last Treatment Visit 	100 	3307 [unit] 	18JAN2014 	Other 	
 	01-710-1045 	83 / F / White 	Treatment 	Last Treatment Visit 	50 	2351 [unit] 	17AUG2013 	Other 	
 	01-710-1053 	84 / F / White 	Treatment 	Last Treatment Visit 	100 	1326 [unit] 	15FEB2013 	Other 	
 	01-710-1154 	84 / M / American Indian or Alaska Native 	Treatment 	Last Treatment Visit 	100 	774 [unit] 	09MAY2014 	Other 	
 	01-710-1166 	81 / F / White 	Treatment 	Last Treatment Visit 	200 	2262 [unit] 	30MAR2013 	Other 	
 	01-710-1300 	78 / F / American Indian or Alaska Native 	Treatment 	Last Treatment Visit 	300 	385 [unit] 	19FEB2013 	Other 	
 	01-710-1358 	82 / M / Asian 	Treatment 	Last Treatment Visit 	100 	1754 [unit] 	12MAR2013 	Other 	
 	01-711-1143 	76 / F / Black or African American 	Treatment 	Last Treatment Visit 	200 	4182 [unit] 	01JUN2013 	Other 	
 	01-714-1068 	79 / F / Other 	Treatment 	Last Treatment Visit 	50 	1659 [unit] 	16OCT2013 	Other 	
 	01-715-1107 	65 / M / Asian 	Treatment 	Last Treatment Visit 	50 	1737 [unit] 	13MAY2013 	Other 	
 	01-716-1063 	80 / M / Asian 	Treatment 	Last Treatment Visit 	50 	4153 [unit] 	28AUG2013 	Other 	
 	01-716-1151 	83 / F / Native Hawaiian or other Pacific Islander 	Treatment 	Last Treatment Visit 	50 	4803 [unit] 	07JUN2013 	Other 	
 	01-716-1311 	78 / M / Black or African American 	Treatment 	Last Treatment Visit 	50 	626 [unit] 	30SEP2014 	Other 	
 	01-718-1066 	79 / F / Asian 	Treatment 	Last Treatment Visit 	300 	655 [unit] 	30JUL2013 	Other 	
 	01-718-1079 	67 / F / White 	Treatment 	Last Treatment Visit 	100 	102 [unit] 	06NOV2012 	Other 	
 	01-718-1250 	82 / F / Black or African American 	Treatment 	Last Treatment Visit 	100 	665 [unit] 	08FEB2014 	Other 	
Placebo 	01-701-1023 	64 / M / Black or African American 	Treatment 	Last Treatment Visit 	50 	795 [unit] 	02SEP2012 	Other 	
 	01-701-1047 	85 / F / Native Hawaiian or other Pacific Islander 	Treatment 	Last Treatment Visit 	50 	208 [unit] 	29MAR2013 	Other 	
 	01-701-1345 	63 / F / Other 	Treatment 	Last Treatment Visit 	50 	2543 [unit] 	18MAR2014 	Other 	
 	01-701-1387 	87 / F / Unknown 	Treatment 	Last Treatment Visit 	300 	4173 [unit] 	25MAR2014 	Other 	
 	01-703-1096 	81 / F / Black or African American 	Treatment 	Last Treatment Visit 	300 	1544 [unit] 	29MAR2013 	Other 	
 	01-703-1175 	75 / M / Multiple 	Treatment 	Last Treatment Visit 	100 	1562 [unit] 	31DEC2013 	Other 	
 	01-704-1260 	71 / F / Not reported 	Treatment 	Last Treatment Visit 	400 	2313 [unit] 	18JAN2013 	Other 	
 	01-704-1435 	74 / M / Not reported 	Treatment 	Last Treatment Visit 	300 	833 [unit] 	12JAN2013 	Other 	

a Last visit is the last visit which the subject attended before discontinuing study [treatment/agent]. 	
a Last visit is the last visit which the subject attended before discontinuing study [treatment/agent].	
a Last visit is the last visit which the subject attended before discontinuing study [treatment/agent].	
a Last visit is the last visit which the subject attended before discontinuing study [treatment/agent].	
a Last visit is the last visit which the subject attended before discontinuing study [treatment/agent].	
a Last visit is the last visit which the subject attended before discontinuing study [treatment/agent].	
a Last visit is the last visit which the subject attended before discontinuing study [treatment/agent].	
a Last visit is the last visit which the subject attended before discontinuing study [treatment/agent].	
a Last visit is the last visit which the subject attended before discontinuing study [treatment/agent].	
b Study day is relative to [the start of [study treatment]]. 	b Study day is relative to [the start of [study treatment]].	b Study day is relative to [the start of [study treatment]].	b Study day is relative to [the start of [study treatment]].	b Study day is relative to [the start of [study treatment]].	b Study day is relative to [the start of [study treatment]].	b Study day is relative to [the start of [study treatment]].	b Study day is relative to [the start of [study treatment]].	b Study day is relative to [the start of [study treatment]].	
c Total dose is defined as a cumulative sum of all study agent administered. 	c Total dose is defined as a cumulative sum of all study agent administered.	c Total dose is defined as a cumulative sum of all study agent administered.	c Total dose is defined as a cumulative sum of all study agent administered.	c Total dose is defined as a cumulative sum of all study agent administered.	c Total dose is defined as a cumulative sum of all study agent administered.	c Total dose is defined as a cumulative sum of all study agent administered.	c Total dose is defined as a cumulative sum of all study agent administered.	c Total dose is defined as a cumulative sum of all study agent administered.