LSIDS02:	Listing of Subjects Who Discontinued Study Participation Prematurely;  Analysis Set (Study jjcs - core)											
Treatment Group 	Subject ID 	Age (years) / Sex / Race 	Last Study Visita 	Study Dayb of Discontinuation 	Last Treatment Visitc 	Study Dayb of Last Study Agent Administered 	Total Dose (unit)d 	Date of Discontinuation 	Primary Reason for Discontinuation 	Was Blind Broken? 	
Xanomeline High Dose 	01-701-1146 	75 / F / Unknown 	Last Study Visit 	42 	Last Treatment Visit 	400 	682 [unit] 	30JUN2013 	Other 	Yes 	
 	01-701-1181 	79 / F / Not reported 	Last Study Visit 	8 	Last Treatment Visit 	200 	3375 [unit] 	12DEC2013 	Other 	Yes 	
 	01-701-1360 	67 / M / Multiple 	Last Study Visit 	15 	Last Treatment Visit 	50 	3744 [unit] 	14AUG2013 	Other 	Yes 	
 	01-701-1444 	63 / M / American Indian or Alaska Native 	Last Study Visit 	40 	Last Treatment Visit 	100 	3217 [unit] 	13FEB2013 	Other 	Yes 	
 	01-703-1076 	69 / M / White 	Last Study Visit 	61 	Last Treatment Visit 	50 	4866 [unit] 	24DEC2013 	Other 	Yes 	
 	01-703-1335 	67 / F / Not reported 	Last Study Visit 	69 	Last Treatment Visit 	300 	4144 [unit] 	24MAY2014 	Other 	Yes 	
 	01-703-1403 	67 / M / Multiple 	Last Study Visit 	8 	Last Treatment Visit 	200 	4799 [unit] 	19DEC2012 	Other 	Yes 	
 	01-704-1017 	77 / M / Asian 	Last Study Visit 	50 	Last Treatment Visit 	200 	1561 [unit] 	24NOV2013 	Other 	Yes 	
 	01-704-1065 	75 / M / Multiple 	Last Study Visit 	62 	Last Treatment Visit 	300 	4487 [unit] 	24DEC2013 	Other 	Yes 	
 	01-704-1093 	79 / M / American Indian or Alaska Native 	Last Study Visit 	98 	Last Treatment Visit 	400 	1035 [unit] 	20JUN2013 	Other 	Yes 	
 	01-705-1281 	73 / F / Not reported 	Last Study Visit 	110 	Last Treatment Visit 	300 	4016 [unit] 	17MAR2014 	Other 	Yes 	
 	01-705-1303 	72 / M / Unknown 	Last Study Visit 	169 	Last Treatment Visit 	200 	4880 [unit] 	02JUN2014 	Other 	Yes 	
 	01-705-1310 	74 / F / Native Hawaiian or other Pacific Islander 	Last Study Visit 	83 	Last Treatment Visit 	50 	2580 [unit] 	23JAN2014 	Other 	Yes 	
 	01-705-1382 	82 / M / Multiple 	Last Study Visit 	1 	Last Treatment Visit 	100 	868 [unit] 	13MAY2013 	Other 	Yes 	
 	01-708-1213 	76 / F / Unknown 	Last Study Visit 	18 	Last Treatment Visit 	200 	4105 [unit] 	26FEB2013 	Other 	Yes 	
 	01-708-1216 	78 / M / Asian 	Last Study Visit 	44 	Last Treatment Visit 	100 	4138 [unit] 	06DEC2012 	Other 	Yes 	
 	01-708-1236 	86 / F / White 	Last Study Visit 	6 	Last Treatment Visit 	300 	3262 [unit] 	26SEP2013 	Other 	Yes 	
 	01-708-1347 	61 / F / White 	Last Study Visit 	60 	Last Treatment Visit 	200 	2169 [unit] 	18JUN2013 	Other 	Yes 	
 	01-708-1372 	84 / M / Not reported 	Last Study Visit 	29 	Last Treatment Visit 	400 	1322 [unit] 	10MAY2013 	Other 	Yes 	
 	01-709-1329 	70 / M / Native Hawaiian or other Pacific Islander 	Last Study Visit 	15 	Last Treatment Visit 	300 	756 [unit] 	29AUG2013 	Other 	Yes 	
 	01-710-1137 	79 / F / Multiple 	Last Study Visit 	34 	Last Treatment Visit 	300 	4505 [unit] 	13NOV2013 	Other 	Yes 	
 	01-710-1142 	76 / F / Not reported 	Last Study Visit 	22 	Last Treatment Visit 	100 	1884 [unit] 	23OCT2012 	Other 	Yes 	
 	01-710-1278 	81 / M / Asian 	Last Study Visit 	70 	Last Treatment Visit 	300 	1435 [unit] 	03MAR2013 	Other 	Yes 	
 	01-711-1433 	84 / F / Asian 	Last Study Visit 	11 	Last Treatment Visit 	400 	2045 [unit] 	06FEB2013 	Other 	Yes 	
 	01-713-1141 	79 / M / White 	Last Study Visit 	68 	Last Treatment Visit 	400 	2384 [unit] 	06AUG2013 	Other 	Yes 	
 	01-714-1425 	81 / M / Black or African American 	Last Study Visit 	8 	Last Treatment Visit 	50 	3686 [unit] 	22AUG2013 	Other 	Yes 	
 	01-715-1319 	65 / M / Multiple 	Last Study Visit 	30 	Last Treatment Visit 	300 	3797 [unit] 	18MAR2013 	Other 	Yes 	
 	01-715-1321 	75 / F / Native Hawaiian or other Pacific Islander 	Last Study Visit 	71 	Last Treatment Visit 	400 	1625 [unit] 	22APR2014 	Other 	Yes 	
 	01-716-1189 	81 / M / Asian 	Last Study Visit 	146 	Last Treatment Visit 	400 	1369 [unit] 	03MAR2013 	Other 	Yes 	
 	01-716-1229 	73 / F / Asian 	Last Study Visit 	42 	Last Treatment Visit 	200 	3984 [unit] 	02APR2013 	Other 	Yes 	
 	01-717-1357 	77 / M / White 	Last Study Visit 	173 	Last Treatment Visit 	100 	3353 [unit] 	20OCT2013 	Other 	Yes 	
 	01-718-1101 	82 / M / Asian 	Last Study Visit 	167 	Last Treatment Visit 	100 	4406 [unit] 	02AUG2013 	Other 	Yes 	
 	01-718-1328 	86 / M / Not reported 	Last Study Visit 	90 	Last Treatment Visit 	100 	3352 [unit] 	01MAY2013 	Other 	Yes 	
 	01-718-1371 	69 / F / Unknown 	Last Study Visit 	105 	Last Treatment Visit 	400 	3454 [unit] 	08AUG2013 	Other 	Yes 	
Xanomeline Low Dose 	01-701-1111 	81 / F / White 	Last Study Visit 	11 	Last Treatment Visit 	200 	2572 [unit] 	17SEP2012 	Other 	Yes 	
 	01-701-1115 	84 / M / Black or African American 	Last Study Visit 	55 	Last Treatment Visit 	400 	3252 [unit] 	23JAN2013 	Other 	Yes 	
 	01-701-1211 	76 / F / Other 	Last Study Visit 	61 	Last Treatment Visit 	50 	4245 [unit] 	14JAN2013 	Other 	Yes 	
 	01-701-1294 	67 / M / Other 	Last Study Visit 	83 	Last Treatment Visit 	400 	2017 [unit] 	14JUN2013 	Other 	Yes 	
 	01-701-1341 	51 / M / American Indian or Alaska Native 	Last Study Visit 	34 	Last Treatment Visit 	100 	1354 [unit] 	07FEB2013 	Other 	Yes 	
 	01-701-1429 	84 / F / American Indian or Alaska Native 	Last Study Visit 	43 	Last Treatment Visit 	50 	2949 [unit] 	30APR2013 	Other 	Yes 	
 	01-703-1119 	81 / F / Native Hawaiian or other Pacific Islander 	Last Study Visit 	114 	Last Treatment Visit 	300 	2288 [unit] 	13JUN2013 	Other 	Yes 	
 	01-703-1182 	84 / M / Other 	Last Study Visit 	57 	Last Treatment Visit 	300 	2075 [unit] 	12DEC2013 	Other 	Yes 	
 	01-703-1197 	76 / F / Other 	Last Study Visit 	37 	Last Treatment Visit 	300 	1716 [unit] 	22JUL2013 	Other 	Yes 	
 	01-704-1009 	83 / M / Unknown 	Last Study Visit 	37 	Last Treatment Visit 	300 	2204 [unit] 	02OCT2013 	Other 	Yes 	
 	01-704-1025 	81 / F / Asian 	Last Study Visit 	64 	Last Treatment Visit 	200 	958 [unit] 	29NOV2013 	Other 	Yes 	
 	01-704-1114 	77 / M / Multiple 	Last Study Visit 	167 	Last Treatment Visit 	50 	967 [unit] 	08JUL2013 	Other 	Yes 	
 	01-704-1120 	71 / F / Black or African American 	Last Study Visit 	64 	Last Treatment Visit 	50 	4345 [unit] 	03FEB2014 	Other 	Yes 	
 	01-704-1325 	81 / M / White 	Last Study Visit 	106 	Last Treatment Visit 	300 	4663 [unit] 	06AUG2014 	Other 	Yes 	
 	01-705-1199 	87 / M / Black or African American 	Last Study Visit 	14 	Last Treatment Visit 	50 	493 [unit] 	29SEP2013 	Other 	Yes 	
 	01-705-1393 	84 / F / Native Hawaiian or other Pacific Islander 	Last Study Visit 	167 	Last Treatment Visit 	300 	3762 [unit] 	20FEB2013 	Other 	Yes 	
 	01-708-1019 	68 / M / Asian 	Last Study Visit 	35 	Last Treatment Visit 	400 	1177 [unit] 	23JAN2014 	Other 	Yes 	
 	01-708-1032 	62 / M / Multiple 	Last Study Visit 	29 	Last Treatment Visit 	100 	3770 [unit] 	09MAR2013 	Other 	Yes 	
 	01-708-1272 	82 / M / Not reported 	Last Study Visit 	58 	Last Treatment Visit 	200 	201 [unit] 	04APR2013 	Other 	Yes 	
 	01-708-1297 	61 / M / Not reported 	Last Study Visit 	104 	Last Treatment Visit 	300 	3732 [unit] 	08MAY2013 	Other 	Yes 	
 	01-709-1081 	86 / F / White 	Last Study Visit 	113 	Last Treatment Visit 	100 	4439 [unit] 	10MAY2014 	Other 	Yes 	
 	01-709-1102 	71 / F / American Indian or Alaska Native 	Last Study Visit 	76 	Last Treatment Visit 	100 	250 [unit] 	31MAR2013 	Other 	Yes 	
 	01-709-1217 	77 / M / American Indian or Alaska Native 	Last Study Visit 	114 	Last Treatment Visit 	400 	3360 [unit] 	25JUN2013 	Other 	Yes 	
 	01-709-1285 	87 / M / Native Hawaiian or other Pacific Islander 	Last Study Visit 	69 	Last Treatment Visit 	100 	3992 [unit] 	31MAY2013 	Other 	Yes 	
 	01-710-1002 	88 / M / American Indian or Alaska Native 	Last Study Visit 	5 	Last Treatment Visit 	100 	3307 [unit] 	18JAN2014 	Other 	Yes 	
 	01-710-1053 	84 / F / White 	Last Study Visit 	52 	Last Treatment Visit 	100 	1326 [unit] 	15FEB2013 	Other 	Yes 	
 	01-710-1154 	84 / M / American Indian or Alaska Native 	Last Study Visit 	42 	Last Treatment Visit 	100 	774 [unit] 	09MAY2014 	Other 	Yes 	
 	01-710-1166 	81 / F / White 	Last Study Visit 	121 	Last Treatment Visit 	200 	2262 [unit] 	30MAR2013 	Other 	Yes 	
 	01-710-1270 	83 / F / American Indian or Alaska Native 	Last Study Visit 	18 	Last Treatment Visit 	300 	1047 [unit] 	01MAR2014 	Other 	Yes 	
 	01-710-1358 	82 / M / Asian 	Last Study Visit 	177 	Last Treatment Visit 	100 	1754 [unit] 	12MAR2013 	Other 	Yes 	
 	01-710-1385 	77 / M / Multiple 	Last Study Visit 	113 	Last Treatment Visit 	400 	4978 [unit] 	18FEB2013 	Other 	Yes 	
 	01-711-1143 	76 / F / Black or African American 	Last Study Visit 	60 	Last Treatment Visit 	200 	4182 [unit] 	01JUN2013 	Other 	Yes 	
 	01-713-1448 	71 / F / American Indian or Alaska Native 	Last Study Visit 	119 	Last Treatment Visit 	100 	774 [unit] 	17MAY2014 	Other 	Yes 	
 	01-714-1068 	79 / F / Other 	Last Study Visit 	70 	Last Treatment Visit 	50 	1659 [unit] 	16OCT2013 	Other 	Yes 	
 	01-716-1063 	80 / M / Asian 	Last Study Visit 	112 	Last Treatment Visit 	50 	4153 [unit] 	28AUG2013 	Other 	Yes 	
 	01-716-1094 	82 / M / Black or African American 	Last Study Visit 	39 	Last Treatment Visit 	200 	2465 [unit] 	26JAN2013 	Other 	Yes 	
 	01-716-1311 	78 / M / Black or African American 	Last Study Visit 	140 	Last Treatment Visit 	50 	626 [unit] 	30SEP2014 	Other 	Yes 	
 	01-718-1079 	67 / F / White 	Last Study Visit 	49 	Last Treatment Visit 	100 	102 [unit] 	06NOV2012 	Other 	Yes 	
 	01-718-1250 	82 / F / Black or African American 	Last Study Visit 	141 	Last Treatment Visit 	100 	665 [unit] 	08FEB2014 	Other 	Yes 	
Placebo 	01-701-1023 	64 / M / Black or African American 	Last Study Visit 	29 	Last Treatment Visit 	50 	795 [unit] 	02SEP2012 	Other 	Yes 	
 	01-701-1047 	85 / F / Native Hawaiian or other Pacific Islander 	Last Study Visit 	46 	Last Treatment Visit 	50 	208 [unit] 	29MAR2013 	Other 	Yes 	
 	01-701-1345 	63 / F / Other 	Last Study Visit 	162 	Last Treatment Visit 	50 	2543 [unit] 	18MAR2014 	Other 	Yes 	
 	01-701-1387 	87 / F / Unknown 	Last Study Visit 	14 	Last Treatment Visit 	300 	4173 [unit] 	25MAR2014 	Other 	Yes 	
 	01-703-1096 	81 / F / Black or African American 	Last Study Visit 	64 	Last Treatment Visit 	300 	1544 [unit] 	29MAR2013 	Other 	Yes 	
 	01-703-1175 	75 / M / Multiple 	Last Study Visit 	12 	Last Treatment Visit 	100 	1562 [unit] 	31DEC2013 	Other 	Yes 	
 	01-704-1233 	87 / F / Not reported 	Last Study Visit 	116 	Last Treatment Visit 	400 	4514 [unit] 	14JUL2013 	Other 	Yes 	
 	01-704-1260 	71 / F / Not reported 	Last Study Visit 	142 	Last Treatment Visit 	400 	2313 [unit] 	18JAN2013 	Other 	Yes 	
 	01-705-1059 	66 / F / Other 	Last Study Visit 	123 	Last Treatment Visit 	100 	2531 [unit] 	05DEC2013 	Other 	Yes 	
 	01-708-1378 	67 / M / Other 	Last Study Visit 	148 	Last Treatment Visit 	400 	2773 [unit] 	28JAN2014 	Other 	Yes 	
 	01-709-1259 	82 / M / Other 	Last Study Visit 	139 	Last Treatment Visit 	300 	4418 [unit] 	13JUN2013 	Other 	Yes 	
 	01-710-1314 	78 / F / Asian 	Last Study Visit 	32 	Last Treatment Visit 	300 	4148 [unit] 	25MAY2013 	Other 	Yes 	
 	01-710-1315 	83 / F / Unknown 	Last Study Visit 	140 	Last Treatment Visit 	200 	2660 [unit] 	16JUL2013 	Other 	Yes 	
 	01-715-1155 	59 / F / Multiple 	Last Study Visit 	135 	Last Treatment Visit 	200 	655 [unit] 	26APR2014 	Other 	Yes 	
 	01-717-1201 	85 / F / Native Hawaiian or other Pacific Islander 	Last Study Visit 	65 	Last Treatment Visit 	50 	2506 [unit] 	21FEB2014 	Other 	Yes 	
 	01-718-1172 	74 / M / Multiple 	Last Study Visit 	70 	Last Treatment Visit 	50 	4945 [unit] 	29NOV2013 	Other 	Yes 	

a Last study visit is the last visit which the subject attended before discontinuing study participation prematurely. 	
a Last study visit is the last visit which the subject attended before discontinuing study participation prematurely.	
a Last study visit is the last visit which the subject attended before discontinuing study participation prematurely.	
a Last study visit is the last visit which the subject attended before discontinuing study participation prematurely.	
a Last study visit is the last visit which the subject attended before discontinuing study participation prematurely.	
a Last study visit is the last visit which the subject attended before discontinuing study participation prematurely.	
a Last study visit is the last visit which the subject attended before discontinuing study participation prematurely.	
a Last study visit is the last visit which the subject attended before discontinuing study participation prematurely.	
a Last study visit is the last visit which the subject attended before discontinuing study participation prematurely.	
a Last study visit is the last visit which the subject attended before discontinuing study participation prematurely.	
a Last study visit is the last visit which the subject attended before discontinuing study participation prematurely.	
b Study day is relative to [the start of [study treatment]]. 	b Study day is relative to [the start of [study treatment]].	b Study day is relative to [the start of [study treatment]].	b Study day is relative to [the start of [study treatment]].	b Study day is relative to [the start of [study treatment]].	b Study day is relative to [the start of [study treatment]].	b Study day is relative to [the start of [study treatment]].	b Study day is relative to [the start of [study treatment]].	b Study day is relative to [the start of [study treatment]].	b Study day is relative to [the start of [study treatment]].	b Study day is relative to [the start of [study treatment]].	
c Last treatment visit is the visit which the subject attended before discontinuing study participation where treatment was administered. 	c Last treatment visit is the visit which the subject attended before discontinuing study participation where treatment was administered.	c Last treatment visit is the visit which the subject attended before discontinuing study participation where treatment was administered.	c Last treatment visit is the visit which the subject attended before discontinuing study participation where treatment was administered.	c Last treatment visit is the visit which the subject attended before discontinuing study participation where treatment was administered.	c Last treatment visit is the visit which the subject attended before discontinuing study participation where treatment was administered.	c Last treatment visit is the visit which the subject attended before discontinuing study participation where treatment was administered.	c Last treatment visit is the visit which the subject attended before discontinuing study participation where treatment was administered.	c Last treatment visit is the visit which the subject attended before discontinuing study participation where treatment was administered.	c Last treatment visit is the visit which the subject attended before discontinuing study participation where treatment was administered.	c Last treatment visit is the visit which the subject attended before discontinuing study participation where treatment was administered.	
d Total dose is defined as a cumulative sum of all study agent administered. 	d Total dose is defined as a cumulative sum of all study agent administered.	d Total dose is defined as a cumulative sum of all study agent administered.	d Total dose is defined as a cumulative sum of all study agent administered.	d Total dose is defined as a cumulative sum of all study agent administered.	d Total dose is defined as a cumulative sum of all study agent administered.	d Total dose is defined as a cumulative sum of all study agent administered.	d Total dose is defined as a cumulative sum of all study agent administered.	d Total dose is defined as a cumulative sum of all study agent administered.	d Total dose is defined as a cumulative sum of all study agent administered.	d Total dose is defined as a cumulative sum of all study agent administered.