LSFECG01:	Listing of Subjects With [Criteria] ECG Values; Safety Analysis Set (Study jjcs - core)										
Treatment Group 	Subject ID 	Age (years) / Sex / Race 	ECG Parameter (unit) 	Assessment Date / Time (Study Daya) 	Visit 	Time Point 	Result 	Change from Baseline 	Criteria 	
Xanomeline High Dose 	01-701-1028 	71 / M / Asian 	ECG Mean Heart Rate (beats/min) 	19JUL2013 / 06:00 (1) 	Baseline 	BEFORE TREATMENT 	38 N CS 	 	 	
 	 	 	 	01AUG2013 / 06:00 (14) 	Month 1 	BEFORE TREATMENT 	195 N CS 	157 	>100 	
 	 	 	 	14AUG2013 / 06:00 (27) 	Month 3 	BEFORE TREATMENT 	285 N CS 	247 	>100 	
 	 	 	 	29AUG2013 / 06:00 (42) 	Month 6 	BEFORE TREATMENT 	499 N CS 	461 	>100 	
 	 	 	 	10SEP2013 / 06:00 (54) 	Month 9 	BEFORE TREATMENT 	343 N CS 	305 	>100 	
 	 	 	 	09OCT2013 / 06:00 (83) 	Month 12 	BEFORE TREATMENT 	309 N CS 	271 	>100 	
 	 	 	 	06NOV2013 / 06:00 (111) 	Month 15 	BEFORE TREATMENT 	458 N CS 	420 	>100 	
 	 	 	 	04DEC2013 / 06:00 (139) 	Month 18 	BEFORE TREATMENT 	19 N CS 	-19 	 	
 	 	 	 	06JAN2014 / 06:00 (172) 	Month 24 	BEFORE TREATMENT 	194 N CS 	156 	>100 	
 	 	 	PR Interval, Aggregate (msec) 	19JUL2013 / 06:00 (1) 	Baseline 	BEFORE TREATMENT 	370 H CS 	 	>200 	
 	 	 	 	01AUG2013 / 06:00 (14) 	Month 1 	BEFORE TREATMENT 	363 H CS 	-7 	>200 	
 	 	 	 	14AUG2013 / 06:00 (27) 	Month 3 	BEFORE TREATMENT 	98 H CS 	-272 	 	
 	 	 	 	29AUG2013 / 06:00 (42) 	Month 6 	BEFORE TREATMENT 	196 N CS 	-174 	 	
 	 	 	 	10SEP2013 / 06:00 (54) 	Month 9 	BEFORE TREATMENT 	333 H CS 	-37 	>200 	
 	 	 	 	09OCT2013 / 06:00 (83) 	Month 12 	BEFORE TREATMENT 	149 H CS 	-221 	 	
 	 	 	 	06NOV2013 / 06:00 (111) 	Month 15 	BEFORE TREATMENT 	201 H CS 	-169 	>200 	
 	 	 	 	04DEC2013 / 06:00 (139) 	Month 18 	BEFORE TREATMENT 	530 H CS 	160 	>200 	
 	 	 	 	06JAN2014 / 06:00 (172) 	Month 24 	BEFORE TREATMENT 	596 H CS 	226 	>200 	
 	01-701-1034 	77 / F / White 	ECG Mean Heart Rate (beats/min) 	01JUL2014 / 06:00 (1) 	Baseline 	BEFORE TREATMENT 	257 N CS 	 	>100 	
 	 	 	 	15JUL2014 / 06:00 (15) 	Month 1 	BEFORE TREATMENT 	176 N CS 	-81 	>100 	
 	 	 	 	29JUL2014 / 06:00 (29) 	Month 3 	BEFORE TREATMENT 	385 N CS 	128 	>100 	
 	 	 	 	11AUG2014 / 06:00 (42) 	Month 6 	BEFORE TREATMENT 	140 N CS 	-117 	>100 	
 	 	 	 	26AUG2014 / 06:00 (57) 	Month 9 	BEFORE TREATMENT 	23 N CS 	-234 	 	
 	 	 	 	25SEP2014 / 06:00 (87) 	Month 12 	BEFORE TREATMENT 	465 N CS 	208 	>100 	
 	 	 	 	21OCT2014 / 06:00 (113) 	Month 15 	BEFORE TREATMENT 	129 N CS 	-128 	>100 	
 	 	 	 	18NOV2014 / 06:00 (141) 	Month 18 	BEFORE TREATMENT 	164 N CS 	-93 	>100 	
 	 	 	 	17DEC2014 / 06:00 (170) 	Month 24 	BEFORE TREATMENT 	587 N CS 	330 	>100 	
 	 	 	PR Interval, Aggregate (msec) 	01JUL2014 / 06:00 (1) 	Baseline 	BEFORE TREATMENT 	472 H CS 	 	>200 	
 	 	 	 	15JUL2014 / 06:00 (15) 	Month 1 	BEFORE TREATMENT 	68 H CS 	-404 	 	
 	 	 	 	29JUL2014 / 06:00 (29) 	Month 3 	BEFORE TREATMENT 	168 H CS 	-304 	 	
 	 	 	 	11AUG2014 / 06:00 (42) 	Month 6 	BEFORE TREATMENT 	254 H CS 	-218 	>200 	
 	 	 	 	26AUG2014 / 06:00 (57) 	Month 9 	BEFORE TREATMENT 	513 H CS 	41 	>200 	
 	 	 	 	25SEP2014 / 06:00 (87) 	Month 12 	BEFORE TREATMENT 	273 H CS 	-199 	>200 	
 	 	 	 	21OCT2014 / 06:00 (113) 	Month 15 	BEFORE TREATMENT 	137 H CS 	-335 	 	
 	 	 	 	18NOV2014 / 06:00 (141) 	Month 18 	BEFORE TREATMENT 	512 H CS 	40 	>200 	
 	 	 	 	17DEC2014 / 06:00 (170) 	Month 24 	BEFORE TREATMENT 	579 H CS 	107 	>200 	
 	01-701-1146 	75 / F / Unknown 	ECG Mean Heart Rate (beats/min) 	20MAY2013 / 06:00 (1) 	Baseline 	BEFORE TREATMENT 	199 N CS 	 	>100 	
 	 	 	 	03JUN2013 / 06:00 (15) 	Month 1 	BEFORE TREATMENT 	236 N CS 	37 	>100 	
 	 	 	 	16JUN2013 / 06:00 (28) 	Month 3 	BEFORE TREATMENT 	257 N CS 	58 	>100 	
 	 	 	 	30JUN2013 / 06:00 (42) 	Month 6 	BEFORE TREATMENT 	379 N CS 	180 	>100 	
 	 	 	PR Interval, Aggregate (msec) 	20MAY2013 / 06:00 (1) 	Baseline 	BEFORE TREATMENT 	52 H CS 	 	 	
 	 	 	 	03JUN2013 / 06:00 (15) 	Month 1 	BEFORE TREATMENT 	499 H CS 	447 	>200 	
 	 	 	 	16JUN2013 / 06:00 (28) 	Month 3 	BEFORE TREATMENT 	126 H CS 	74 	 	
 	 	 	 	30JUN2013 / 06:00 (42) 	Month 6 	BEFORE TREATMENT 	142 H CS 	90 	 	
 	01-701-1148 	57 / M / Not reported 	ECG Mean Heart Rate (beats/min) 	23AUG2013 / 06:00 (1) 	Baseline 	BEFORE TREATMENT 	420 N CS 	 	>100 	
 	 	 	 	05SEP2013 / 06:00 (14) 	Month 1 	BEFORE TREATMENT 	443 N CS 	23 	>100 	
 	 	 	 	19SEP2013 / 06:00 (28) 	Month 3 	BEFORE TREATMENT 	28 N CS 	-392 	 	
 	 	 	 	03OCT2013 / 06:00 (42) 	Month 6 	BEFORE TREATMENT 	240 N CS 	-180 	>100 	
 	 	 	 	18OCT2013 / 06:00 (57) 	Month 9 	BEFORE TREATMENT 	41 N CS 	-379 	 	
 	 	 	 	17NOV2013 / 06:00 (87) 	Month 12 	BEFORE TREATMENT 	43 N CS 	-377 	 	
 	 	 	 	13DEC2013 / 06:00 (113) 	Month 15 	BEFORE TREATMENT 	223 N CS 	-197 	>100 	
 	 	 	 	10JAN2014 / 06:00 (141) 	Month 18 	BEFORE TREATMENT 	7 N CS 	-413 	 	
 	 	 	 	08FEB2014 / 06:00 (170) 	Month 24 	BEFORE TREATMENT 	550 N CS 	130 	>100 	
 	 	 	PR Interval, Aggregate (msec) 	23AUG2013 / 06:00 (1) 	Baseline 	BEFORE TREATMENT 	484 H CS 	 	>200 	
 	 	 	 	05SEP2013 / 06:00 (14) 	Month 1 	BEFORE TREATMENT 	217 H CS 	-267 	>200 	
 	 	 	 	19SEP2013 / 06:00 (28) 	Month 3 	BEFORE TREATMENT 	321 H CS 	-163 	>200 	
 	 	 	 	03OCT2013 / 06:00 (42) 	Month 6 	BEFORE TREATMENT 	296 H CS 	-188 	>200 	
 	 	 	 	18OCT2013 / 06:00 (57) 	Month 9 	BEFORE TREATMENT 	360 H CS 	-124 	>200 	
 	 	 	 	17NOV2013 / 06:00 (87) 	Month 12 	BEFORE TREATMENT 	89 H CS 	-395 	 	
 	 	 	 	13DEC2013 / 06:00 (113) 	Month 15 	BEFORE TREATMENT 	188 H CS 	-296 	 	
 	 	 	 	10JAN2014 / 06:00 (141) 	Month 18 	BEFORE TREATMENT 	569 H CS 	85 	>200 	
 	 	 	 	08FEB2014 / 06:00 (170) 	Month 24 	BEFORE TREATMENT 	440 H CS 	-44 	>200 	
 	01-701-1239 	56 / M / White 	ECG Mean Heart Rate (beats/min) 	11JAN2014 / 06:00 (1) 	Baseline 	BEFORE TREATMENT 	379 N CS 	 	>100 	
 	 	 	 	25JAN2014 / 06:00 (15) 	Month 1 	BEFORE TREATMENT 	407 N CS 	28 	>100 	
 	 	 	 	08FEB2014 / 06:00 (29) 	Month 3 	BEFORE TREATMENT 	134 N CS 	-245 	>100 	
 	 	 	 	19FEB2014 / 06:00 (40) 	Month 6 	BEFORE TREATMENT 	194 N CS 	-185 	>100 	
 	 	 	 	06MAR2014 / 06:00 (55) 	Month 9 	BEFORE TREATMENT 	206 N CS 	-173 	>100 	
 	 	 	 	02APR2014 / 06:00 (82) 	Month 12 	BEFORE TREATMENT 	474 N CS 	95 	>100 	
 	 	 	 	02MAY2014 / 06:00 (112) 	Month 15 	BEFORE TREATMENT 	279 N CS 	-100 	>100 	
 	 	 	 	28MAY2014 / 06:00 (138) 	Month 18 	BEFORE TREATMENT 	598 N CS 	219 	>100 	
 	 	 	 	27JUN2014 / 06:00 (168) 	Month 24 	BEFORE TREATMENT 	45 N CS 	-334 	 	
 	 	 	PR Interval, Aggregate (msec) 	11JAN2014 / 06:00 (1) 	Baseline 	BEFORE TREATMENT 	445 N CS 	 	>200 	
 	 	 	 	25JAN2014 / 06:00 (15) 	Month 1 	BEFORE TREATMENT 	358 H CS 	-87 	>200 	
 	 	 	 	08FEB2014 / 06:00 (29) 	Month 3 	BEFORE TREATMENT 	430 H CS 	-15 	>200 	
 	 	 	 	19FEB2014 / 06:00 (40) 	Month 6 	BEFORE TREATMENT 	582 H CS 	137 	>200 	
 	 	 	 	06MAR2014 / 06:00 (55) 	Month 9 	BEFORE TREATMENT 	570 H CS 	125 	>200 	
 	 	 	 	02APR2014 / 06:00 (82) 	Month 12 	BEFORE TREATMENT 	40 H CS 	-405 	 	
 	 	 	 	02MAY2014 / 06:00 (112) 	Month 15 	BEFORE TREATMENT 	343 H CS 	-102 	>200 	
 	 	 	 	28MAY2014 / 06:00 (138) 	Month 18 	BEFORE TREATMENT 	142 H CS 	-303 	 	
 	 	 	 	27JUN2014 / 06:00 (168) 	Month 24 	BEFORE TREATMENT 	0 H CS 	-445 	 	
 	01-701-1275 	61 / M / White 	ECG Mean Heart Rate (beats/min) 	07FEB2014 / 06:00 (1) 	Baseline 	BEFORE TREATMENT 	286 N CS 	 	>100 	
 	 	 	 	22FEB2014 / 06:00 (16) 	Month 1 	BEFORE TREATMENT 	50 N CS 	-236 	 	
 	 	 	 	07MAR2014 / 06:00 (29) 	Month 3 	BEFORE TREATMENT 	528 N CS 	242 	>100 	
 	 	 	 	22MAR2014 / 06:00 (44) 	Month 6 	BEFORE TREATMENT 	456 N CS 	170 	>100 	
 	 	 	 	05APR2014 / 06:00 (58) 	Month 9 	BEFORE TREATMENT 	433 N CS 	147 	>100 	
 	 	 	 	03MAY2014 / 06:00 (86) 	Month 12 	BEFORE TREATMENT 	328 N CS 	42 	>100 	
 	 	 	 	14JUN2014 / 06:00 (128) 	Month 15 	BEFORE TREATMENT 	317 N CS 	31 	>100 	
 	 	 	PR Interval, Aggregate (msec) 	07FEB2014 / 06:00 (1) 	Baseline 	BEFORE TREATMENT 	357 H CS 	 	>200 	
 	 	 	 	22FEB2014 / 06:00 (16) 	Month 1 	BEFORE TREATMENT 	538 H CS 	181 	>200 	
 	 	 	 	07MAR2014 / 06:00 (29) 	Month 3 	BEFORE TREATMENT 	13 H CS 	-344 	 	
 	 	 	 	22MAR2014 / 06:00 (44) 	Month 6 	BEFORE TREATMENT 	587 H CS 	230 	>200 	
 	 	 	 	05APR2014 / 06:00 (58) 	Month 9 	BEFORE TREATMENT 	503 H CS 	146 	>200 	
 	 	 	 	03MAY2014 / 06:00 (86) 	Month 12 	BEFORE TREATMENT 	256 H CS 	-101 	>200 	
 	 	 	 	14JUN2014 / 06:00 (128) 	Month 15 	BEFORE TREATMENT 	591 H CS 	234 	>200 	
 	01-701-1287 	56 / F / Multiple 	ECG Mean Heart Rate (beats/min) 	25JAN2014 / 06:00 (1) 	Baseline 	BEFORE TREATMENT 	171 N CS 	 	>100 	
 	 	 	 	11FEB2014 / 06:00 (18) 	Month 1 	BEFORE TREATMENT 	321 N CS 	150 	>100 	
 	 	 	 	20FEB2014 / 06:00 (27) 	Month 3 	BEFORE TREATMENT 	164 N CS 	-7 	>100 	
 	 	 	 	06MAR2014 / 06:00 (41) 	Month 6 	BEFORE TREATMENT 	274 N CS 	103 	>100 	
 	 	 	 	21MAR2014 / 06:00 (56) 	Month 9 	BEFORE TREATMENT 	76 N CS 	-95 	 	
 	 	 	 	17APR2014 / 06:00 (83) 	Month 12 	BEFORE TREATMENT 	102 N CS 	-69 	>100 	

a Study day is relative to [the start of [study treatment]]. 	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].