LSFECG02:	Listing of ECG Values; Safety Analysis Set (Study jjcs - core)										
Treatment Group 	Subject ID 	Age (years) / Sex / Race 	ECG Parameter (unit) 	Assessment Date / Time (Study Daya) 	Visit 	Time Point 	Result 	Change from Baseline 	Criteria 	
Xanomeline High Dose 	01-701-1028 	71 / M / Asian 	ECG Mean Heart Rate (beats/min) 	19JUL2013 / 06:00 (1) 	Baseline 	BEFORE TREATMENT 	38 N NCS 	 	<50 	
 	 	 	 	01AUG2013 / 06:00 (14) 	Month 1 	BEFORE TREATMENT 	195 N CS 	157 	>100 	
 	 	 	 	14AUG2013 / 06:00 (27) 	Month 3 	BEFORE TREATMENT 	285 N CS 	247 	>100 	
 	 	 	 	29AUG2013 / 06:00 (42) 	Month 6 	BEFORE TREATMENT 	499 N CS 	461 	>100 	
 	 	 	 	10SEP2013 / 06:00 (54) 	Month 9 	BEFORE TREATMENT 	343 N CS 	305 	>100 	
 	 	 	 	09OCT2013 / 06:00 (83) 	Month 12 	BEFORE TREATMENT 	309 N CS 	271 	>100 	
 	 	 	 	06NOV2013 / 06:00 (111) 	Month 15 	BEFORE TREATMENT 	458 N CS 	420 	>100 	
 	 	 	 	04DEC2013 / 06:00 (139) 	Month 18 	BEFORE TREATMENT 	19 N NCS 	-19 	<50 	
 	 	 	 	06JAN2014 / 06:00 (172) 	Month 24 	BEFORE TREATMENT 	194 N CS 	156 	>100 	
 	 	 	Interpretation 	19JUL2013 / 06:00 (1) 	Baseline 	BEFORE TREATMENT 	ABNORMAL CS 	 	 	
 	 	 	 	01AUG2013 / 06:00 (14) 	Month 1 	BEFORE TREATMENT 	NORMAL 	 	 	
 	 	 	 	14AUG2013 / 06:00 (27) 	Month 3 	BEFORE TREATMENT 	NORMAL 	 	 	
 	 	 	 	29AUG2013 / 06:00 (42) 	Month 6 	BEFORE TREATMENT 	NORMAL 	 	 	
 	 	 	 	10SEP2013 / 06:00 (54) 	Month 9 	BEFORE TREATMENT 	NORMAL 	 	 	
 	 	 	 	09OCT2013 / 06:00 (83) 	Month 12 	BEFORE TREATMENT 	ABNORMAL CS 	 	 	
 	 	 	 	06NOV2013 / 06:00 (111) 	Month 15 	BEFORE TREATMENT 	NORMAL 	 	 	
 	 	 	 	04DEC2013 / 06:00 (139) 	Month 18 	BEFORE TREATMENT 	ABNORMAL CS 	 	 	
 	 	 	 	06JAN2014 / 06:00 (172) 	Month 24 	BEFORE TREATMENT 	NORMAL 	 	 	
 	 	 	PR Interval, Aggregate (msec) 	19JUL2013 / 06:00 (1) 	Baseline 	BEFORE TREATMENT 	370 H CS 	 	>200 	
 	 	 	 	01AUG2013 / 06:00 (14) 	Month 1 	BEFORE TREATMENT 	363 H CS 	-7 	>200 	
 	 	 	 	14AUG2013 / 06:00 (27) 	Month 3 	BEFORE TREATMENT 	98 H NCS 	-272 	<120 	
 	 	 	 	29AUG2013 / 06:00 (42) 	Month 6 	BEFORE TREATMENT 	196 N NCS 	-174 	 	
 	 	 	 	10SEP2013 / 06:00 (54) 	Month 9 	BEFORE TREATMENT 	333 H CS 	-37 	>200 	
 	 	 	 	09OCT2013 / 06:00 (83) 	Month 12 	BEFORE TREATMENT 	149 H NCS 	-221 	 	
 	 	 	 	06NOV2013 / 06:00 (111) 	Month 15 	BEFORE TREATMENT 	201 H CS 	-169 	>200 	
 	 	 	 	04DEC2013 / 06:00 (139) 	Month 18 	BEFORE TREATMENT 	530 H CS 	160 	>200 	
 	 	 	 	06JAN2014 / 06:00 (172) 	Month 24 	BEFORE TREATMENT 	596 H CS 	226 	>200 	
 	 	 	QRS Duration, Aggregate (msec) 	19JUL2013 / 06:00 (1) 	Baseline 	BEFORE TREATMENT 	241 N NCS 	 	 	
 	 	 	 	01AUG2013 / 06:00 (14) 	Month 1 	BEFORE TREATMENT 	179 N NCS 	-62 	 	
 	 	 	 	14AUG2013 / 06:00 (27) 	Month 3 	BEFORE TREATMENT 	520 N NCS 	279 	 	
 	 	 	 	29AUG2013 / 06:00 (42) 	Month 6 	BEFORE TREATMENT 	419 N NCS 	178 	 	
 	 	 	 	10SEP2013 / 06:00 (54) 	Month 9 	BEFORE TREATMENT 	493 N NCS 	252 	 	
 	 	 	 	09OCT2013 / 06:00 (83) 	Month 12 	BEFORE TREATMENT 	141 N NCS 	-100 	 	
 	 	 	 	06NOV2013 / 06:00 (111) 	Month 15 	BEFORE TREATMENT 	266 N NCS 	25 	 	
 	 	 	 	04DEC2013 / 06:00 (139) 	Month 18 	BEFORE TREATMENT 	184 N NCS 	-57 	 	
 	 	 	 	06JAN2014 / 06:00 (172) 	Month 24 	BEFORE TREATMENT 	592 N NCS 	351 	 	
 	 	 	QT Interval, Corrected (msec) 	19JUL2013 / 06:00 (1) 	Baseline 	BEFORE TREATMENT 	230 H NCS 	 	 	
 	 	 	 	01AUG2013 / 06:00 (14) 	Month 1 	BEFORE TREATMENT 	278 H NCS 	48 	 	
 	 	 	 	14AUG2013 / 06:00 (27) 	Month 3 	BEFORE TREATMENT 	241 N NCS 	11 	 	
 	 	 	 	29AUG2013 / 06:00 (42) 	Month 6 	BEFORE TREATMENT 	215 L NCS 	-15 	 	
 	 	 	 	10SEP2013 / 06:00 (54) 	Month 9 	BEFORE TREATMENT 	337 H NCS 	107 	 	
 	 	 	 	09OCT2013 / 06:00 (83) 	Month 12 	BEFORE TREATMENT 	508 H CS 	278 	 	
 	 	 	 	06NOV2013 / 06:00 (111) 	Month 15 	BEFORE TREATMENT 	402 H NCS 	172 	 	
 	 	 	 	04DEC2013 / 06:00 (139) 	Month 18 	BEFORE TREATMENT 	332 H NCS 	102 	 	
 	 	 	 	06JAN2014 / 06:00 (172) 	Month 24 	BEFORE TREATMENT 	440 H NCS 	210 	 	
 	 	 	QTcB Interval, Aggregate (msec) 	19JUL2013 / 06:00 (1) 	Baseline 	BEFORE TREATMENT 	319 H NCS 	 	 	
 	 	 	 	01AUG2013 / 06:00 (14) 	Month 1 	BEFORE TREATMENT 	367 H NCS 	48 	 	
 	 	 	 	14AUG2013 / 06:00 (27) 	Month 3 	BEFORE TREATMENT 	473 H NCS 	154 	 	
 	 	 	 	29AUG2013 / 06:00 (42) 	Month 6 	BEFORE TREATMENT 	423 H NCS 	104 	 	
 	 	 	 	10SEP2013 / 06:00 (54) 	Month 9 	BEFORE TREATMENT 	336 H NCS 	17 	 	
 	 	 	 	09OCT2013 / 06:00 (83) 	Month 12 	BEFORE TREATMENT 	393 H NCS 	74 	 	
 	 	 	 	06NOV2013 / 06:00 (111) 	Month 15 	BEFORE TREATMENT 	287 H NCS 	-32 	 	
 	 	 	 	04DEC2013 / 06:00 (139) 	Month 18 	BEFORE TREATMENT 	374 H NCS 	55 	 	
 	 	 	 	06JAN2014 / 06:00 (172) 	Month 24 	BEFORE TREATMENT 	348 H NCS 	29 	 	
 	 	 	QTcF Interval, Aggregate (msec) 	19JUL2013 / 06:00 (1) 	Baseline 	BEFORE TREATMENT 	379 H NCS 	 	 	
 	 	 	 	01AUG2013 / 06:00 (14) 	Month 1 	BEFORE TREATMENT 	356 H NCS 	-23 	 	
 	 	 	 	14AUG2013 / 06:00 (27) 	Month 3 	BEFORE TREATMENT 	452 H NCS 	73 	 	
 	 	 	 	29AUG2013 / 06:00 (42) 	Month 6 	BEFORE TREATMENT 	300 N NCS 	-79 	 	
 	 	 	 	10SEP2013 / 06:00 (54) 	Month 9 	BEFORE TREATMENT 	303 H NCS 	-76 	 	
 	 	 	 	09OCT2013 / 06:00 (83) 	Month 12 	BEFORE TREATMENT 	269 H NCS 	-110 	 	
 	 	 	 	06NOV2013 / 06:00 (111) 	Month 15 	BEFORE TREATMENT 	352 H NCS 	-27 	 	
 	 	 	 	04DEC2013 / 06:00 (139) 	Month 18 	BEFORE TREATMENT 	261 H NCS 	-118 	 	
 	 	 	 	06JAN2014 / 06:00 (172) 	Month 24 	BEFORE TREATMENT 	348 H NCS 	-31 	 	
 	 	 	RR Interval, Aggregate (msec) 	19JUL2013 / 06:00 (1) 	Baseline 	BEFORE TREATMENT 	53 L NCS 	 	 	
 	 	 	 	01AUG2013 / 06:00 (14) 	Month 1 	BEFORE TREATMENT 	476 L NCS 	423 	 	
 	 	 	 	14AUG2013 / 06:00 (27) 	Month 3 	BEFORE TREATMENT 	498 L NCS 	445 	 	
 	 	 	 	29AUG2013 / 06:00 (42) 	Month 6 	BEFORE TREATMENT 	212 L NCS 	159 	 	
 	 	 	 	10SEP2013 / 06:00 (54) 	Month 9 	BEFORE TREATMENT 	469 L NCS 	416 	 	
 	 	 	 	09OCT2013 / 06:00 (83) 	Month 12 	BEFORE TREATMENT 	419 L NCS 	366 	 	
 	 	 	 	06NOV2013 / 06:00 (111) 	Month 15 	BEFORE TREATMENT 	54 L NCS 	1 	 	
 	 	 	 	04DEC2013 / 06:00 (139) 	Month 18 	BEFORE TREATMENT 	479 L NCS 	426 	 	
 	 	 	 	06JAN2014 / 06:00 (172) 	Month 24 	BEFORE TREATMENT 	137 L NCS 	84 	 	
 	01-701-1034 	77 / F / White 	ECG Mean Heart Rate (beats/min) 	01JUL2014 / 06:00 (1) 	Baseline 	BEFORE TREATMENT 	257 N CS 	 	>100 	
 	 	 	 	15JUL2014 / 06:00 (15) 	Month 1 	BEFORE TREATMENT 	176 N CS 	-81 	>100 	
 	 	 	 	29JUL2014 / 06:00 (29) 	Month 3 	BEFORE TREATMENT 	385 N CS 	128 	>100 	
 	 	 	 	11AUG2014 / 06:00 (42) 	Month 6 	BEFORE TREATMENT 	140 N CS 	-117 	>100 	
 	 	 	 	26AUG2014 / 06:00 (57) 	Month 9 	BEFORE TREATMENT 	23 N NCS 	-234 	<50 	
 	 	 	 	25SEP2014 / 06:00 (87) 	Month 12 	BEFORE TREATMENT 	465 N CS 	208 	>100 	
 	 	 	 	21OCT2014 / 06:00 (113) 	Month 15 	BEFORE TREATMENT 	129 N CS 	-128 	>100 	
 	 	 	 	18NOV2014 / 06:00 (141) 	Month 18 	BEFORE TREATMENT 	164 N CS 	-93 	>100 	
 	 	 	 	17DEC2014 / 06:00 (170) 	Month 24 	BEFORE TREATMENT 	587 N CS 	330 	>100 	
 	 	 	Interpretation 	01JUL2014 / 06:00 (1) 	Baseline 	BEFORE TREATMENT 	ABNORMAL CS 	 	 	
 	 	 	 	15JUL2014 / 06:00 (15) 	Month 1 	BEFORE TREATMENT 	NORMAL 	 	 	
 	 	 	 	29JUL2014 / 06:00 (29) 	Month 3 	BEFORE TREATMENT 	ABNORMAL NCS 	 	 	
 	 	 	 	11AUG2014 / 06:00 (42) 	Month 6 	BEFORE TREATMENT 	ABNORMAL NCS 	 	 	
 	 	 	 	26AUG2014 / 06:00 (57) 	Month 9 	BEFORE TREATMENT 	NORMAL 	 	 	
 	 	 	 	25SEP2014 / 06:00 (87) 	Month 12 	BEFORE TREATMENT 	NORMAL 	 	 	
 	 	 	 	21OCT2014 / 06:00 (113) 	Month 15 	BEFORE TREATMENT 	NORMAL 	 	 	
 	 	 	 	18NOV2014 / 06:00 (141) 	Month 18 	BEFORE TREATMENT 	NORMAL 	 	 	
 	 	 	 	17DEC2014 / 06:00 (170) 	Month 24 	BEFORE TREATMENT 	ABNORMAL NCS 	 	 	
 	 	 	PR Interval, Aggregate (msec) 	01JUL2014 / 06:00 (1) 	Baseline 	BEFORE TREATMENT 	472 H CS 	 	>200 	
 	 	 	 	15JUL2014 / 06:00 (15) 	Month 1 	BEFORE TREATMENT 	68 H NCS 	-404 	<120 	
 	 	 	 	29JUL2014 / 06:00 (29) 	Month 3 	BEFORE TREATMENT 	168 H NCS 	-304 	 	
 	 	 	 	11AUG2014 / 06:00 (42) 	Month 6 	BEFORE TREATMENT 	254 H CS 	-218 	>200 	
 	 	 	 	26AUG2014 / 06:00 (57) 	Month 9 	BEFORE TREATMENT 	513 H CS 	41 	>200 	
 	 	 	 	25SEP2014 / 06:00 (87) 	Month 12 	BEFORE TREATMENT 	273 H CS 	-199 	>200 	
 	 	 	 	21OCT2014 / 06:00 (113) 	Month 15 	BEFORE TREATMENT 	137 H NCS 	-335 	 	
 	 	 	 	18NOV2014 / 06:00 (141) 	Month 18 	BEFORE TREATMENT 	512 H CS 	40 	>200 	
 	 	 	 	17DEC2014 / 06:00 (170) 	Month 24 	BEFORE TREATMENT 	579 H CS 	107 	>200 	
 	 	 	QRS Duration, Aggregate (msec) 	01JUL2014 / 06:00 (1) 	Baseline 	BEFORE TREATMENT 	406 N NCS 	 	 	

a Study day is relative to [the start of [study treatment]]. 	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].