LSFVIT01:	Listing of Subjects With Clinically Important Vital Signs; Safety Analysis Set (Study jjcs - core)										
Treatment Group 	Subject ID 	Age (years) / Sex / Race 	Vital Sign (unit) 	Assessment Date / Time (Study Daya) 	Visit 	Time Point 	Result 	Change From Baseline 	Criteria 	
Xanomeline High Dose 	01-701-1028 	71 / M / Asian 	Diastolic Blood Pressure Orthostatic (mmHg) 	19JUL2013 / 06:00 (1) 	Screening 	BEFORE TREATMENT 	1 N 	 	 	
 	 	 	 	01AUG2013 / 06:00 (14) 	Cycle 02 	BEFORE TREATMENT 	-10 N 	-11 	 	
 	 	 	 	01AUG2014 / 06:00 (14) 	Cycle 10 	BEFORE TREATMENT 	-10 N 	-11 	 	
 	 	 	 	14AUG2013 / 06:00 (27) 	Cycle 03 	BEFORE TREATMENT 	16 N 	15 	 	
 	 	 	 	14AUG2014 / 06:00 (27) 	Cycle 11 	BEFORE TREATMENT 	16 N 	15 	 	
 	 	 	 	29AUG2013 / 06:00 (42) 	Cycle 04 	BEFORE TREATMENT 	18 N 	17 	 	
 	 	 	 	29AUG2014 / 06:00 (42) 	Cycle 12 	BEFORE TREATMENT 	18 N 	17 	 	
 	 	 	 	10SEP2013 / 06:00 (54) 	Cycle 05 	BEFORE TREATMENT 	19 H 	18 	 	
 	 	 	 	10SEP2014 / 06:00 (54) 	Cycle 13 	BEFORE TREATMENT 	19 H 	18 	 	
 	 	 	 	09OCT2013 / 06:00 (83) 	Cycle 06 	BEFORE TREATMENT 	0 N 	-1 	 	
 	 	 	 	09OCT2014 / 06:00 (83) 	Cycle 15 	BEFORE TREATMENT 	0 N 	-1 	 	
 	 	 	 	06NOV2013 / 06:00 (111) 	Cycle 07 	BEFORE TREATMENT 	21 N 	20 	 	
 	 	 	 	06NOV2014 / 06:00 (111) 	Cycle 17 	BEFORE TREATMENT 	21 N 	20 	 	
 	 	 	 	04DEC2013 / 06:00 (139) 	Cycle 08 	BEFORE TREATMENT 	-14 N 	-15 	Orthostatic DBP <-10 	
 	 	 	 	04DEC2014 / 06:00 (139) 	Cycle 19 	BEFORE TREATMENT 	-14 N 	-15 	Orthostatic DBP <-10 	
 	 	 	 	04DEC2015 / 06:00 (139) 	Cycle 22 	BEFORE TREATMENT 	-14 N 	-15 	Orthostatic DBP <-10 	
 	 	 	 	06JAN2014 / 06:00 (172) 	Cycle 09 	BEFORE TREATMENT 	25 N 	24 	 	
 	 	 	 	06JAN2015 / 06:00 (172) 	Cycle 21 	BEFORE TREATMENT 	25 N 	24 	 	
 	 	 	 	06JAN2016 / 06:00 (172) 	Cycle 25 	BEFORE TREATMENT 	25 N 	24 	 	
 	 	 	 	14JAN2014 / 06:00 (180) 	End Of Treatment 	BEFORE TREATMENT 	9 N 	8 	 	
 	 	 	 	14JAN2015 / 06:00 (180) 	Cycle 23 	BEFORE TREATMENT 	9 N 	8 	 	
 	 	 	 	14JAN2016 / 06:00 (180) 	Cycle 29 	BEFORE TREATMENT 	9 N 	8 	 	
 	 	 	Pulse Rate Orthostatic (beats/min) 	19JUL2013 / 06:00 (1) 	Screening 	BEFORE TREATMENT 	19 N 	 	Orthostatic Pulse Rate >15 	
 	 	 	 	01AUG2013 / 06:00 (14) 	Cycle 02 	BEFORE TREATMENT 	18 N 	-1 	Orthostatic Pulse Rate >15 	
 	 	 	 	01AUG2014 / 06:00 (14) 	Cycle 10 	BEFORE TREATMENT 	18 N 	-1 	Orthostatic Pulse Rate >15 	
 	 	 	 	14AUG2013 / 06:00 (27) 	Cycle 03 	BEFORE TREATMENT 	22 N 	3 	Orthostatic Pulse Rate >15 	
 	 	 	 	14AUG2014 / 06:00 (27) 	Cycle 11 	BEFORE TREATMENT 	22 N 	3 	Orthostatic Pulse Rate >15 	
 	 	 	 	29AUG2013 / 06:00 (42) 	Cycle 04 	BEFORE TREATMENT 	-18 L 	-37 	 	
 	 	 	 	29AUG2014 / 06:00 (42) 	Cycle 12 	BEFORE TREATMENT 	-18 L 	-37 	 	
 	 	 	 	10SEP2013 / 06:00 (54) 	Cycle 05 	BEFORE TREATMENT 	17 N 	-2 	Orthostatic Pulse Rate >15 	
 	 	 	 	10SEP2014 / 06:00 (54) 	Cycle 13 	BEFORE TREATMENT 	17 N 	-2 	Orthostatic Pulse Rate >15 	
 	 	 	 	09OCT2013 / 06:00 (83) 	Cycle 06 	BEFORE TREATMENT 	-18 N 	-37 	 	
 	 	 	 	09OCT2014 / 06:00 (83) 	Cycle 15 	BEFORE TREATMENT 	-18 N 	-37 	 	
 	 	 	 	06NOV2013 / 06:00 (111) 	Cycle 07 	BEFORE TREATMENT 	9 N 	-10 	 	
 	 	 	 	06NOV2014 / 06:00 (111) 	Cycle 17 	BEFORE TREATMENT 	9 N 	-10 	 	
 	 	 	 	04DEC2013 / 06:00 (139) 	Cycle 08 	BEFORE TREATMENT 	8 N 	-11 	 	
 	 	 	 	04DEC2014 / 06:00 (139) 	Cycle 19 	BEFORE TREATMENT 	8 N 	-11 	 	
 	 	 	 	04DEC2015 / 06:00 (139) 	Cycle 22 	BEFORE TREATMENT 	8 N 	-11 	 	
 	 	 	 	06JAN2014 / 06:00 (172) 	Cycle 09 	BEFORE TREATMENT 	-1 N 	-20 	 	
 	 	 	 	06JAN2015 / 06:00 (172) 	Cycle 21 	BEFORE TREATMENT 	-1 N 	-20 	 	
 	 	 	 	06JAN2016 / 06:00 (172) 	Cycle 25 	BEFORE TREATMENT 	-1 N 	-20 	 	
 	 	 	 	14JAN2014 / 06:00 (180) 	End Of Treatment 	BEFORE TREATMENT 	0 L 	-19 	 	
 	 	 	 	14JAN2015 / 06:00 (180) 	Cycle 23 	BEFORE TREATMENT 	0 L 	-19 	 	
 	 	 	 	14JAN2016 / 06:00 (180) 	Cycle 29 	BEFORE TREATMENT 	0 L 	-19 	 	
 	 	 	Systolic Blood Pressure Orthostatic (mmHg) 	19JUL2013 / 06:00 (1) 	Screening 	BEFORE TREATMENT 	-23 H 	 	Orthostatic SBP <-20 	
 	 	 	 	01AUG2013 / 06:00 (14) 	Cycle 02 	BEFORE TREATMENT 	-19 H 	4 	 	
 	 	 	 	01AUG2014 / 06:00 (14) 	Cycle 10 	BEFORE TREATMENT 	-19 H 	4 	 	
 	 	 	 	14AUG2013 / 06:00 (27) 	Cycle 03 	BEFORE TREATMENT 	-18 H 	5 	 	
 	 	 	 	14AUG2014 / 06:00 (27) 	Cycle 11 	BEFORE TREATMENT 	-18 H 	5 	 	
 	 	 	 	29AUG2013 / 06:00 (42) 	Cycle 04 	BEFORE TREATMENT 	-13 H 	10 	 	
 	 	 	 	29AUG2014 / 06:00 (42) 	Cycle 12 	BEFORE TREATMENT 	-13 H 	10 	 	
 	 	 	 	10SEP2013 / 06:00 (54) 	Cycle 05 	BEFORE TREATMENT 	2 H 	25 	 	
 	 	 	 	10SEP2014 / 06:00 (54) 	Cycle 13 	BEFORE TREATMENT 	2 H 	25 	 	
 	 	 	 	09OCT2013 / 06:00 (83) 	Cycle 06 	BEFORE TREATMENT 	26 H 	49 	 	
 	 	 	 	09OCT2014 / 06:00 (83) 	Cycle 15 	BEFORE TREATMENT 	26 H 	49 	 	
 	 	 	 	06NOV2013 / 06:00 (111) 	Cycle 07 	BEFORE TREATMENT 	-4 N 	19 	 	
 	 	 	 	06NOV2014 / 06:00 (111) 	Cycle 17 	BEFORE TREATMENT 	-4 N 	19 	 	
 	 	 	 	04DEC2013 / 06:00 (139) 	Cycle 08 	BEFORE TREATMENT 	-6 N 	17 	 	
 	 	 	 	04DEC2014 / 06:00 (139) 	Cycle 19 	BEFORE TREATMENT 	-6 N 	17 	 	
 	 	 	 	04DEC2015 / 06:00 (139) 	Cycle 22 	BEFORE TREATMENT 	-6 N 	17 	 	
 	 	 	 	06JAN2014 / 06:00 (172) 	Cycle 09 	BEFORE TREATMENT 	7 H 	30 	 	
 	 	 	 	06JAN2015 / 06:00 (172) 	Cycle 21 	BEFORE TREATMENT 	7 H 	30 	 	
 	 	 	 	06JAN2016 / 06:00 (172) 	Cycle 25 	BEFORE TREATMENT 	7 H 	30 	 	
 	 	 	 	14JAN2014 / 06:00 (180) 	End Of Treatment 	BEFORE TREATMENT 	-10 N 	13 	 	
 	 	 	 	14JAN2015 / 06:00 (180) 	Cycle 23 	BEFORE TREATMENT 	-10 N 	13 	 	
 	 	 	 	14JAN2016 / 06:00 (180) 	Cycle 29 	BEFORE TREATMENT 	-10 N 	13 	 	
 	01-701-1034 	77 / F / White 	Diastolic Blood Pressure Orthostatic (mmHg) 	01JUL2014 / 06:00 (1) 	Screening 	BEFORE TREATMENT 	-8 N 	 	 	
 	 	 	 	15JUL2014 / 06:00 (15) 	Cycle 02 	BEFORE TREATMENT 	-1 H 	7 	 	
 	 	 	 	15JUL2015 / 06:00 (15) 	Cycle 10 	BEFORE TREATMENT 	-1 H 	7 	 	
 	 	 	 	29JUL2014 / 06:00 (29) 	Cycle 03 	BEFORE TREATMENT 	-15 N 	-7 	Orthostatic DBP <-10 	
 	 	 	 	29JUL2015 / 06:00 (29) 	Cycle 11 	BEFORE TREATMENT 	-15 N 	-7 	Orthostatic DBP <-10 	
 	 	 	 	11AUG2014 / 06:00 (42) 	Cycle 04 	BEFORE TREATMENT 	-6 N 	2 	 	
 	 	 	 	11AUG2015 / 06:00 (42) 	Cycle 12 	BEFORE TREATMENT 	-6 N 	2 	 	
 	 	 	 	26AUG2014 / 06:00 (57) 	Cycle 05 	BEFORE TREATMENT 	1 N 	9 	 	
 	 	 	 	26AUG2015 / 06:00 (57) 	Cycle 13 	BEFORE TREATMENT 	1 N 	9 	 	
 	 	 	 	25SEP2014 / 06:00 (87) 	Cycle 06 	BEFORE TREATMENT 	-17 N 	-9 	Orthostatic DBP <-10 	
 	 	 	 	25SEP2015 / 06:00 (87) 	Cycle 15 	BEFORE TREATMENT 	-17 N 	-9 	Orthostatic DBP <-10 	
 	 	 	 	21OCT2014 / 06:00 (113) 	Cycle 07 	BEFORE TREATMENT 	11 N 	19 	 	
 	 	 	 	21OCT2015 / 06:00 (113) 	Cycle 17 	BEFORE TREATMENT 	11 N 	19 	 	
 	 	 	 	18NOV2014 / 06:00 (141) 	Cycle 08 	BEFORE TREATMENT 	-16 N 	-8 	Orthostatic DBP <-10 	
 	 	 	 	18NOV2015 / 06:00 (141) 	Cycle 19 	BEFORE TREATMENT 	-16 N 	-8 	Orthostatic DBP <-10 	
 	 	 	 	17NOV2016 / 06:00 (141) 	Cycle 22 	BEFORE TREATMENT 	-16 N 	-8 	Orthostatic DBP <-10 	
 	 	 	 	17DEC2014 / 06:00 (170) 	Cycle 09 	BEFORE TREATMENT 	10 H 	18 	 	
 	 	 	 	17DEC2015 / 06:00 (170) 	Cycle 21 	BEFORE TREATMENT 	10 H 	18 	 	
 	 	 	 	16DEC2016 / 06:00 (170) 	Cycle 25 	BEFORE TREATMENT 	10 H 	18 	 	
 	 	 	 	30DEC2014 / 06:00 (183) 	End Of Treatment 	BEFORE TREATMENT 	-8 N 	0 	 	
 	 	 	 	30DEC2015 / 06:00 (183) 	Cycle 23 	BEFORE TREATMENT 	-8 N 	0 	 	
 	 	 	 	29DEC2016 / 06:00 (183) 	Cycle 29 	BEFORE TREATMENT 	-8 N 	0 	 	
 	 	 	Pulse Rate Orthostatic (beats/min) 	01JUL2014 / 06:00 (1) 	Screening 	BEFORE TREATMENT 	14 N 	 	 	
 	 	 	 	15JUL2014 / 06:00 (15) 	Cycle 02 	BEFORE TREATMENT 	13 N 	-1 	 	
 	 	 	 	15JUL2015 / 06:00 (15) 	Cycle 10 	BEFORE TREATMENT 	13 N 	-1 	 	
 	 	 	 	29JUL2014 / 06:00 (29) 	Cycle 03 	BEFORE TREATMENT 	-10 N 	-24 	 	
 	 	 	 	29JUL2015 / 06:00 (29) 	Cycle 11 	BEFORE TREATMENT 	-10 N 	-24 	 	
 	 	 	 	11AUG2014 / 06:00 (42) 	Cycle 04 	BEFORE TREATMENT 	9 N 	-5 	 	
 	 	 	 	11AUG2015 / 06:00 (42) 	Cycle 12 	BEFORE TREATMENT 	9 N 	-5 	 	
 	 	 	 	26AUG2014 / 06:00 (57) 	Cycle 05 	BEFORE TREATMENT 	16 N 	2 	Orthostatic Pulse Rate >15 	
 	 	 	 	26AUG2015 / 06:00 (57) 	Cycle 13 	BEFORE TREATMENT 	16 N 	2 	Orthostatic Pulse Rate >15 	
 	 	 	 	25SEP2014 / 06:00 (87) 	Cycle 06 	BEFORE TREATMENT 	-25 N 	-39 	 	
 	 	 	 	25SEP2015 / 06:00 (87) 	Cycle 15 	BEFORE TREATMENT 	-25 N 	-39 	 	
 	 	 	 	21OCT2014 / 06:00 (113) 	Cycle 07 	BEFORE TREATMENT 	21 N 	7 	Orthostatic Pulse Rate >15 	

a Study day is relative to [the start of [study treatment]]. 	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].