LSFVIT02:	Listing of Vital Signs; Safety Analysis Set (Study jjcs - core)										
Treatment Group 	Subject ID 	Age (years) / Sex / Race 	Vital Sign (unit) 	Assessment Date / Time (Study Daya) 	Visit 	Time Point 	Result 	Change From Baseline 	Criteria 	
Xanomeline High Dose 	01-701-1028 	71 / M / Asian 	DBP (STD-SUP) <-10 	19JUL2013 / 06:00 (1) 	Screening 	BEFORE TREATMENT 	N N 	 	 	
 	 	 	 	01AUG2013 / 06:00 (14) 	Cycle 02 	BEFORE TREATMENT 	N N 	 	 	
 	 	 	 	01AUG2014 / 06:00 (14) 	Cycle 10 	BEFORE TREATMENT 	N N 	 	 	
 	 	 	 	14AUG2013 / 06:00 (27) 	Cycle 03 	BEFORE TREATMENT 	N N 	 	 	
 	 	 	 	14AUG2014 / 06:00 (27) 	Cycle 11 	BEFORE TREATMENT 	N N 	 	 	
 	 	 	 	29AUG2013 / 06:00 (42) 	Cycle 04 	BEFORE TREATMENT 	N N 	 	 	
 	 	 	 	29AUG2014 / 06:00 (42) 	Cycle 12 	BEFORE TREATMENT 	N N 	 	 	
 	 	 	 	10SEP2013 / 06:00 (54) 	Cycle 05 	BEFORE TREATMENT 	N H 	 	 	
 	 	 	 	10SEP2014 / 06:00 (54) 	Cycle 13 	BEFORE TREATMENT 	N H 	 	 	
 	 	 	 	09OCT2013 / 06:00 (83) 	Cycle 06 	BEFORE TREATMENT 	N N 	 	 	
 	 	 	 	09OCT2014 / 06:00 (83) 	Cycle 15 	BEFORE TREATMENT 	N N 	 	 	
 	 	 	 	06NOV2013 / 06:00 (111) 	Cycle 07 	BEFORE TREATMENT 	N N 	 	 	
 	 	 	 	06NOV2014 / 06:00 (111) 	Cycle 17 	BEFORE TREATMENT 	N N 	 	 	
 	 	 	 	04DEC2013 / 06:00 (139) 	Cycle 08 	BEFORE TREATMENT 	Y N 	 	 	
 	 	 	 	04DEC2014 / 06:00 (139) 	Cycle 19 	BEFORE TREATMENT 	Y N 	 	 	
 	 	 	 	04DEC2015 / 06:00 (139) 	Cycle 22 	BEFORE TREATMENT 	Y N 	 	 	
 	 	 	 	06JAN2014 / 06:00 (172) 	Cycle 09 	BEFORE TREATMENT 	N N 	 	 	
 	 	 	 	06JAN2015 / 06:00 (172) 	Cycle 21 	BEFORE TREATMENT 	N N 	 	 	
 	 	 	 	06JAN2016 / 06:00 (172) 	Cycle 25 	BEFORE TREATMENT 	N N 	 	 	
 	 	 	 	14JAN2014 / 06:00 (180) 	End Of Treatment 	BEFORE TREATMENT 	N N 	 	 	
 	 	 	 	14JAN2015 / 06:00 (180) 	Cycle 23 	BEFORE TREATMENT 	N N 	 	 	
 	 	 	 	14JAN2016 / 06:00 (180) 	Cycle 29 	BEFORE TREATMENT 	N N 	 	 	
 	 	 	Diastolic Blood Pressure (mmHg) 	19JUL2013 / 06:00 (1) 	Screening 	BEFORE TREATMENT 	78.6667 N 	 	 	
 	 	 	 	01AUG2013 / 06:00 (14) 	Cycle 02 	BEFORE TREATMENT 	79.3333 N 	0.6667 	 	
 	 	 	 	01AUG2014 / 06:00 (14) 	Cycle 10 	BEFORE TREATMENT 	79.3333 N 	0.6667 	 	
 	 	 	 	14AUG2013 / 06:00 (27) 	Cycle 03 	BEFORE TREATMENT 	69.6667 N 	-9.0000 	 	
 	 	 	 	14AUG2014 / 06:00 (27) 	Cycle 11 	BEFORE TREATMENT 	69.6667 N 	-9.0000 	 	
 	 	 	 	29AUG2013 / 06:00 (42) 	Cycle 04 	BEFORE TREATMENT 	74.0000 N 	-4.6667 	 	
 	 	 	 	29AUG2014 / 06:00 (42) 	Cycle 12 	BEFORE TREATMENT 	74.0000 N 	-4.6667 	 	
 	 	 	 	10SEP2013 / 06:00 (54) 	Cycle 05 	BEFORE TREATMENT 	80.3333 H 	1.6667 	 	
 	 	 	 	10SEP2014 / 06:00 (54) 	Cycle 13 	BEFORE TREATMENT 	80.3333 H 	1.6667 	 	
 	 	 	 	09OCT2013 / 06:00 (83) 	Cycle 06 	BEFORE TREATMENT 	79.0000 N 	0.3333 	 	
 	 	 	 	09OCT2014 / 06:00 (83) 	Cycle 15 	BEFORE TREATMENT 	79.0000 N 	0.3333 	 	
 	 	 	 	06NOV2013 / 06:00 (111) 	Cycle 07 	BEFORE TREATMENT 	76.3333 N 	-2.3333 	 	
 	 	 	 	06NOV2014 / 06:00 (111) 	Cycle 17 	BEFORE TREATMENT 	76.3333 N 	-2.3333 	 	
 	 	 	 	04DEC2013 / 06:00 (139) 	Cycle 08 	BEFORE TREATMENT 	77.3333 N 	-1.3333 	 	
 	 	 	 	04DEC2014 / 06:00 (139) 	Cycle 19 	BEFORE TREATMENT 	77.3333 N 	-1.3333 	 	
 	 	 	 	04DEC2015 / 06:00 (139) 	Cycle 22 	BEFORE TREATMENT 	77.3333 N 	-1.3333 	 	
 	 	 	 	06JAN2014 / 06:00 (172) 	Cycle 09 	BEFORE TREATMENT 	74.0000 N 	-4.6667 	 	
 	 	 	 	06JAN2015 / 06:00 (172) 	Cycle 21 	BEFORE TREATMENT 	74.0000 N 	-4.6667 	 	
 	 	 	 	06JAN2016 / 06:00 (172) 	Cycle 25 	BEFORE TREATMENT 	74.0000 N 	-4.6667 	 	
 	 	 	 	14JAN2014 / 06:00 (180) 	End Of Treatment 	BEFORE TREATMENT 	75.3333 N 	-3.3333 	 	
 	 	 	 	14JAN2015 / 06:00 (180) 	Cycle 23 	BEFORE TREATMENT 	75.3333 N 	-3.3333 	 	
 	 	 	 	14JAN2016 / 06:00 (180) 	Cycle 29 	BEFORE TREATMENT 	75.3333 N 	-3.3333 	 	
 	 	 	Diastolic Blood Pressure Orthostatic (mmHg) 	19JUL2013 / 06:00 (1) 	Screening 	BEFORE TREATMENT 	1 N 	 	 	
 	 	 	 	01AUG2013 / 06:00 (14) 	Cycle 02 	BEFORE TREATMENT 	-10 N 	-11 	 	
 	 	 	 	01AUG2014 / 06:00 (14) 	Cycle 10 	BEFORE TREATMENT 	-10 N 	-11 	 	
 	 	 	 	14AUG2013 / 06:00 (27) 	Cycle 03 	BEFORE TREATMENT 	16 N 	15 	 	
 	 	 	 	14AUG2014 / 06:00 (27) 	Cycle 11 	BEFORE TREATMENT 	16 N 	15 	 	
 	 	 	 	29AUG2013 / 06:00 (42) 	Cycle 04 	BEFORE TREATMENT 	18 N 	17 	 	
 	 	 	 	29AUG2014 / 06:00 (42) 	Cycle 12 	BEFORE TREATMENT 	18 N 	17 	 	
 	 	 	 	10SEP2013 / 06:00 (54) 	Cycle 05 	BEFORE TREATMENT 	19 H 	18 	 	
 	 	 	 	10SEP2014 / 06:00 (54) 	Cycle 13 	BEFORE TREATMENT 	19 H 	18 	 	
 	 	 	 	09OCT2013 / 06:00 (83) 	Cycle 06 	BEFORE TREATMENT 	0 N 	-1 	 	
 	 	 	 	09OCT2014 / 06:00 (83) 	Cycle 15 	BEFORE TREATMENT 	0 N 	-1 	 	
 	 	 	 	06NOV2013 / 06:00 (111) 	Cycle 07 	BEFORE TREATMENT 	21 N 	20 	 	
 	 	 	 	06NOV2014 / 06:00 (111) 	Cycle 17 	BEFORE TREATMENT 	21 N 	20 	 	
 	 	 	 	04DEC2013 / 06:00 (139) 	Cycle 08 	BEFORE TREATMENT 	-14 N 	-15 	Orthostatic DBP <-10 	
 	 	 	 	04DEC2014 / 06:00 (139) 	Cycle 19 	BEFORE TREATMENT 	-14 N 	-15 	Orthostatic DBP <-10 	
 	 	 	 	04DEC2015 / 06:00 (139) 	Cycle 22 	BEFORE TREATMENT 	-14 N 	-15 	Orthostatic DBP <-10 	
 	 	 	 	06JAN2014 / 06:00 (172) 	Cycle 09 	BEFORE TREATMENT 	25 N 	24 	 	
 	 	 	 	06JAN2015 / 06:00 (172) 	Cycle 21 	BEFORE TREATMENT 	25 N 	24 	 	
 	 	 	 	06JAN2016 / 06:00 (172) 	Cycle 25 	BEFORE TREATMENT 	25 N 	24 	 	
 	 	 	 	14JAN2014 / 06:00 (180) 	End Of Treatment 	BEFORE TREATMENT 	9 N 	8 	 	
 	 	 	 	14JAN2015 / 06:00 (180) 	Cycle 23 	BEFORE TREATMENT 	9 N 	8 	 	
 	 	 	 	14JAN2016 / 06:00 (180) 	Cycle 29 	BEFORE TREATMENT 	9 N 	8 	 	
 	 	 	Orthostatic Hypotension 	19JUL2013 / 06:00 (1) 	Screening 	BEFORE TREATMENT 	Y H 	 	 	
 	 	 	 	01AUG2013 / 06:00 (14) 	Cycle 02 	BEFORE TREATMENT 	N H 	 	 	
 	 	 	 	01AUG2014 / 06:00 (14) 	Cycle 10 	BEFORE TREATMENT 	N H 	 	 	
 	 	 	 	14AUG2013 / 06:00 (27) 	Cycle 03 	BEFORE TREATMENT 	N H 	 	 	
 	 	 	 	14AUG2014 / 06:00 (27) 	Cycle 11 	BEFORE TREATMENT 	N H 	 	 	
 	 	 	 	29AUG2013 / 06:00 (42) 	Cycle 04 	BEFORE TREATMENT 	N H 	 	 	
 	 	 	 	29AUG2014 / 06:00 (42) 	Cycle 12 	BEFORE TREATMENT 	N H 	 	 	
 	 	 	 	10SEP2013 / 06:00 (54) 	Cycle 05 	BEFORE TREATMENT 	N H 	 	 	
 	 	 	 	10SEP2014 / 06:00 (54) 	Cycle 13 	BEFORE TREATMENT 	N H 	 	 	
 	 	 	 	09OCT2013 / 06:00 (83) 	Cycle 06 	BEFORE TREATMENT 	N H 	 	 	
 	 	 	 	09OCT2014 / 06:00 (83) 	Cycle 15 	BEFORE TREATMENT 	N H 	 	 	
 	 	 	 	06NOV2013 / 06:00 (111) 	Cycle 07 	BEFORE TREATMENT 	N N 	 	 	
 	 	 	 	06NOV2014 / 06:00 (111) 	Cycle 17 	BEFORE TREATMENT 	N N 	 	 	
 	 	 	 	04DEC2013 / 06:00 (139) 	Cycle 08 	BEFORE TREATMENT 	Y N 	 	 	
 	 	 	 	04DEC2014 / 06:00 (139) 	Cycle 19 	BEFORE TREATMENT 	Y N 	 	 	
 	 	 	 	04DEC2015 / 06:00 (139) 	Cycle 22 	BEFORE TREATMENT 	Y N 	 	 	
 	 	 	 	06JAN2014 / 06:00 (172) 	Cycle 09 	BEFORE TREATMENT 	N H 	 	 	
 	 	 	 	06JAN2015 / 06:00 (172) 	Cycle 21 	BEFORE TREATMENT 	N H 	 	 	
 	 	 	 	06JAN2016 / 06:00 (172) 	Cycle 25 	BEFORE TREATMENT 	N H 	 	 	
 	 	 	 	14JAN2014 / 06:00 (180) 	End Of Treatment 	BEFORE TREATMENT 	N N 	 	 	
 	 	 	 	14JAN2015 / 06:00 (180) 	Cycle 23 	BEFORE TREATMENT 	N N 	 	 	
 	 	 	 	14JAN2016 / 06:00 (180) 	Cycle 29 	BEFORE TREATMENT 	N N 	 	 	
 	 	 	Pulse Rate (beats/min) 	19JUL2013 / 06:00 (1) 	Screening 	BEFORE TREATMENT 	63.3333 N 	 	 	
 	 	 	 	01AUG2013 / 06:00 (14) 	Cycle 02 	BEFORE TREATMENT 	71.3333 N 	8.0000 	 	
 	 	 	 	01AUG2014 / 06:00 (14) 	Cycle 10 	BEFORE TREATMENT 	71.3333 N 	8.0000 	 	
 	 	 	 	14AUG2013 / 06:00 (27) 	Cycle 03 	BEFORE TREATMENT 	75.0000 N 	11.6667 	 	
 	 	 	 	14AUG2014 / 06:00 (27) 	Cycle 11 	BEFORE TREATMENT 	75.0000 N 	11.6667 	 	
 	 	 	 	29AUG2013 / 06:00 (42) 	Cycle 04 	BEFORE TREATMENT 	59.3333 L 	-4.0000 	 	
 	 	 	 	29AUG2014 / 06:00 (42) 	Cycle 12 	BEFORE TREATMENT 	59.3333 L 	-4.0000 	 	
 	 	 	 	10SEP2013 / 06:00 (54) 	Cycle 05 	BEFORE TREATMENT 	74.6667 N 	11.3333 	 	
 	 	 	 	10SEP2014 / 06:00 (54) 	Cycle 13 	BEFORE TREATMENT 	74.6667 N 	11.3333 	 	
 	 	 	 	09OCT2013 / 06:00 (83) 	Cycle 06 	BEFORE TREATMENT 	65.0000 N 	1.6667 	 	
 	 	 	 	09OCT2014 / 06:00 (83) 	Cycle 15 	BEFORE TREATMENT 	65.0000 N 	1.6667 	 	
 	 	 	 	06NOV2013 / 06:00 (111) 	Cycle 07 	BEFORE TREATMENT 	66.3333 N 	3.0000 	 	

a Study day is relative to [the start of [study treatment]]. 	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].	
a Study day is relative to [the start of [study treatment]].