TSFAE20a:	Demographic Characteristics for Subjects With Treatment-emergent Adverse Events; Safety Analysis Set (Study jjcs - core)					
 	Active Study Agent 	Active Study Agent 	Active Study Agent 	 	
 	Xanomeline High Dose 	Xanomeline Low Dose 	Combined 	Placebo 	
Characteristic 	N=53 	N=73 	N=126 	N=59 	
Subjects with ≥ 1 AE 	51 (96.2%) 	62 (84.9%) 	113 (89.7%) 	42 (71.2%) 	
 	 	 	 	 	
Sex, n/Ns (%) 	 	 	 	 	
Male 	28/29 (96.6%) 	30/34 (88.2%) 	58/63 (92.1%) 	16/23 (69.6%) 	
Female 	23/24 (95.8%) 	32/39 (82.1%) 	55/63 (87.3%) 	26/36 (72.2%) 	
 	 	 	 	 	
Age group (years), n/Ns (%) 	 	 	 	 	
≥18 to <65 	8/8 (100.0%) 	5/5 (100.0%) 	13/13 (100.0%) 	3/7 (42.9%) 	
≥65 to <75 	14/16 (87.5%) 	15/17 (88.2%) 	29/33 (87.9%) 	13/19 (68.4%) 	
≥75 	29/29 (100.0%) 	42/51 (82.4%) 	71/80 (88.8%) 	26/33 (78.8%) 	
 	 	 	 	 	
Race, n/Ns (%) 	 	 	 	 	
American Indian or Alaska Native 	5/5 (100.0%) 	9/10 (90.0%) 	14/15 (93.3%) 	3/3 (100.0%) 	
Asian 	10/10 (100.0%) 	9/9 (100.0%) 	19/19 (100.0%) 	5/5 (100.0%) 	
Black or African American 	3/3 (100.0%) 	8/11 (72.7%) 	11/14 (78.6%) 	5/7 (71.4%) 	
Native Hawaiian or other Pacific Islander 	7/7 (100.0%) 	5/5 (100.0%) 	12/12 (100.0%) 	4/5 (80.0%) 	
White 	8/8 (100.0%) 	7/8 (87.5%) 	15/16 (93.8%) 	5/7 (71.4%) 	
Multiple 	8/8 (100.0%) 	8/10 (80.0%) 	16/18 (88.9%) 	1/5 (20.0%) 	
Not reported or unknown 	9/11 (81.8%) 	10/12 (83.3%) 	19/23 (82.6%) 	13/17 (76.5%) 	
Other 	1/1 (100.0%) 	6/8 (75.0%) 	7/9 (77.8%) 	6/10 (60.0%) 	
 	 	 	 	 	
Ethnicity, n/Ns (%) 	 	 	 	 	
Hispanic or Latino 	14/15 (93.3%) 	13/15 (86.7%) 	27/30 (90.0%) 	10/12 (83.3%) 	
Not Hispanic or Latino 	14/15 (93.3%) 	15/18 (83.3%) 	29/33 (87.9%) 	13/16 (81.2%) 	
Not reported or unknown 	23/23 (100.0%) 	34/40 (85.0%) 	57/63 (90.5%) 	19/31 (61.3%) 	

Note:  n=number of subjects with at least one event, Ns=total number of subjects for each specific subgroup 	
Note:  n=number of subjects with at least one event, Ns=total number of subjects for each specific subgroup	
Note:  n=number of subjects with at least one event, Ns=total number of subjects for each specific subgroup	
Note:  n=number of subjects with at least one event, Ns=total number of subjects for each specific subgroup	
Note:  n=number of subjects with at least one event, Ns=total number of subjects for each specific subgroup