TSFAE20b:	Demographic Characteristics for Subjects With Serious Treatment-emergent Adverse Events; Safety Analysis Set (Study jjcs - core)					
 	Active Study Agent 	Active Study Agent 	Active Study Agent 	 	
 	Xanomeline High Dose 	Xanomeline Low Dose 	Combined 	Placebo 	
Characteristic 	N=53 	N=73 	N=126 	N=59 	
Subjects with ≥ 1 SAE 	47 (88.7%) 	54 (74.0%) 	101 (80.2%) 	37 (62.7%) 	
 	 	 	 	 	
Sex, n/Ns (%) 	 	 	 	 	
Male 	27/29 (93.1%) 	29/34 (85.3%) 	56/63 (88.9%) 	16/23 (69.6%) 	
Female 	20/24 (83.3%) 	25/39 (64.1%) 	45/63 (71.4%) 	21/36 (58.3%) 	
 	 	 	 	 	
Age group (years), n/Ns (%) 	 	 	 	 	
≥18 to <65 	7/8 (87.5%) 	4/5 (80.0%) 	11/13 (84.6%) 	3/7 (42.9%) 	
≥65 to <75 	13/16 (81.2%) 	14/17 (82.4%) 	27/33 (81.8%) 	11/19 (57.9%) 	
≥75 	27/29 (93.1%) 	36/51 (70.6%) 	63/80 (78.8%) 	23/33 (69.7%) 	
 	 	 	 	 	
Race, n/Ns (%) 	 	 	 	 	
American Indian or Alaska Native 	5/5 (100.0%) 	8/10 (80.0%) 	13/15 (86.7%) 	2/3 (66.7%) 	
Asian 	10/10 (100.0%) 	8/9 (88.9%) 	18/19 (94.7%) 	5/5 (100.0%) 	
Black or African American 	2/3 (66.7%) 	7/11 (63.6%) 	9/14 (64.3%) 	5/7 (71.4%) 	
Native Hawaiian or other Pacific Islander 	6/7 (85.7%) 	3/5 (60.0%) 	9/12 (75.0%) 	3/5 (60.0%) 	
White 	8/8 (100.0%) 	7/8 (87.5%) 	15/16 (93.8%) 	4/7 (57.1%) 	
Multiple 	7/8 (87.5%) 	7/10 (70.0%) 	14/18 (77.8%) 	1/5 (20.0%) 	
Not reported or unknown 	8/11 (72.7%) 	8/12 (66.7%) 	16/23 (69.6%) 	12/17 (70.6%) 	
Other 	1/1 (100.0%) 	6/8 (75.0%) 	7/9 (77.8%) 	5/10 (50.0%) 	
 	 	 	 	 	
Ethnicity, n/Ns (%) 	 	 	 	 	
Hispanic or Latino 	13/15 (86.7%) 	11/15 (73.3%) 	24/30 (80.0%) 	10/12 (83.3%) 	
Not Hispanic or Latino 	13/15 (86.7%) 	12/18 (66.7%) 	25/33 (75.8%) 	10/16 (62.5%) 	
Not reported or unknown 	21/23 (91.3%) 	31/40 (77.5%) 	52/63 (82.5%) 	17/31 (54.8%) 	

Note:  n=number of subjects with at least one event, Ns=total number of subjects for each specific subgroup 	
Note:  n=number of subjects with at least one event, Ns=total number of subjects for each specific subgroup	
Note:  n=number of subjects with at least one event, Ns=total number of subjects for each specific subgroup	
Note:  n=number of subjects with at least one event, Ns=total number of subjects for each specific subgroup	
Note:  n=number of subjects with at least one event, Ns=total number of subjects for each specific subgroup