TSFAE20c:	Demographic Characteristics for Subjects With Treatment-emergent Adverse Events - [FDA Medical Query of Interest / Preferred Term of Interest]; Safety Analysis Set (Study jjcs - core)					
 	Active Study Agent 	Active Study Agent 	Active Study Agent 	 	
 	Xanomeline High Dose 	Xanomeline Low Dose 	Combined 	Placebo 	
Characteristic 	N=53 	N=73 	N=126 	N=59 	
Subjects with ≥ 1 Abdominal Pain 	46 (86.8%) 	54 (74.0%) 	100 (79.4%) 	33 (55.9%) 	
 	 	 	 	 	
Sex, n/Ns (%) 	 	 	 	 	
Male 	28/29 (96.6%) 	27/34 (79.4%) 	55/63 (87.3%) 	14/23 (60.9%) 	
Female 	18/24 (75.0%) 	27/39 (69.2%) 	45/63 (71.4%) 	19/36 (52.8%) 	
 	 	 	 	 	
Age group (years), n/Ns (%) 	 	 	 	 	
≥18 to <65 	7/8 (87.5%) 	3/5 (60.0%) 	10/13 (76.9%) 	3/7 (42.9%) 	
≥65 to <75 	12/16 (75.0%) 	14/17 (82.4%) 	26/33 (78.8%) 	10/19 (52.6%) 	
≥75 	27/29 (93.1%) 	37/51 (72.5%) 	64/80 (80.0%) 	20/33 (60.6%) 	
 	 	 	 	 	
Race, n/Ns (%) 	 	 	 	 	
American Indian or Alaska Native 	5/5 (100.0%) 	9/10 (90.0%) 	14/15 (93.3%) 	2/3 (66.7%) 	
Asian 	9/10 (90.0%) 	6/9 (66.7%) 	15/19 (78.9%) 	3/5 (60.0%) 	
Black or African American 	3/3 (100.0%) 	7/11 (63.6%) 	10/14 (71.4%) 	4/7 (57.1%) 	
Native Hawaiian or other Pacific Islander 	6/7 (85.7%) 	5/5 (100.0%) 	11/12 (91.7%) 	4/5 (80.0%) 	
White 	7/8 (87.5%) 	6/8 (75.0%) 	13/16 (81.2%) 	4/7 (57.1%) 	
Multiple 	8/8 (100.0%) 	7/10 (70.0%) 	15/18 (83.3%) 	1/5 (20.0%) 	
Not reported or unknown 	7/11 (63.6%) 	9/12 (75.0%) 	16/23 (69.6%) 	11/17 (64.7%) 	
Other 	1/1 (100.0%) 	5/8 (62.5%) 	6/9 (66.7%) 	4/10 (40.0%) 	
 	 	 	 	 	
Ethnicity, n/Ns (%) 	 	 	 	 	
Hispanic or Latino 	12/15 (80.0%) 	12/15 (80.0%) 	24/30 (80.0%) 	6/12 (50.0%) 	
Not Hispanic or Latino 	13/15 (86.7%) 	12/18 (66.7%) 	25/33 (75.8%) 	10/16 (62.5%) 	
Not reported or unknown 	21/23 (91.3%) 	30/40 (75.0%) 	51/63 (81.0%) 	17/31 (54.8%) 	

Note:  n=number of subjects with at least one event, Ns=total number of subjects for each specific subgroup 	
Note:  n=number of subjects with at least one event, Ns=total number of subjects for each specific subgroup	
Note:  n=number of subjects with at least one event, Ns=total number of subjects for each specific subgroup	
Note:  n=number of subjects with at least one event, Ns=total number of subjects for each specific subgroup	
Note:  n=number of subjects with at least one event, Ns=total number of subjects for each specific subgroup