TSFAE23c:	Subjects With Related Treatment-emergent Adverse Events Leading to Discontinuation of Study Treatment by Preferred Term; Safety Analysis Set (Study jjcs - core)					
 	Active Study Agent 	Active Study Agent 	Active Study Agent 	 	
 	Xanomeline High Dose 	Xanomeline Low Dose 	Combined 	Placebo 	
Preferred Term, n (%) 	N=53 	N=73 	N=126 	N=59 	
Subjects with ≥1 related AE leading to discontinuation 	3 (5.7%) 	5 (6.8%) 	8 (6.3%) 	7 (11.9%) 	
 	 	 	 	 	
ASTHENIA 	0 	1 (1.4%) 	1 (0.8%) 	0 	
CHEST PAIN 	1 (1.9%) 	0 	1 (0.8%) 	0 	
CONTUSION 	0 	1 (1.4%) 	1 (0.8%) 	0 	
DIZZINESS 	0 	1 (1.4%) 	1 (0.8%) 	0 	
DYSPHONIA 	0 	1 (1.4%) 	1 (0.8%) 	0 	
HEADACHE 	1 (1.9%) 	0 	1 (0.8%) 	0 	
NASAL CONGESTION 	1 (1.9%) 	0 	1 (0.8%) 	0 	
PALPITATIONS 	0 	1 (1.4%) 	1 (0.8%) 	0 	
DISORIENTATION 	0 	0 	0 	1 (1.7%) 	
ELECTROCARDIOGRAM T WAVE AMPLITUDE DECREASED 	0 	0 	0 	1 (1.7%) 	
EYE PRURITUS 	0 	0 	0 	1 (1.7%) 	
HYPERHIDROSIS 	0 	0 	0 	1 (1.7%) 	
OEDEMA PERIPHERAL 	0 	0 	0 	1 (1.7%) 	
RASH 	0 	0 	0 	1 (1.7%) 	
UPPER RESPIRATORY TRACT INFECTION 	0 	0 	0 	1 (1.7%) 	

Note: An AE is assessed by the investigator as related. Subjects are counted only once for any given event, regardless of the number of times they actually experienced the event. 	
Note: An AE is assessed by the investigator as related. Subjects are counted only once for any given event, regardless of the number of times they actually experienced the event.	
Note: An AE is assessed by the investigator as related. Subjects are counted only once for any given event, regardless of the number of times they actually experienced the event.	
Note: An AE is assessed by the investigator as related. Subjects are counted only once for any given event, regardless of the number of times they actually experienced the event.	
Note: An AE is assessed by the investigator as related. Subjects are counted only once for any given event, regardless of the number of times they actually experienced the event.	
Note: Adverse events are coded using MedDRA version 26.0. 	: Adverse events are coded using MedDRA version 26.	: Adverse events are coded using MedDRA version 26.	: Adverse events are coded using MedDRA version 26.	: Adverse events are coded using MedDRA version 26.