TSFLAB07:	Shift in Laboratory Values From Baseline to Worst Grade [During Time Period] Based on NCI-CTCAE Criteria; Safety Analysis Set (Study jjcs - core)								
NCI-CTCAE Category 	 	Baseline Toxicity Grade 	Baseline Toxicity Grade 	Baseline Toxicity Grade 	Baseline Toxicity Grade 	Baseline Toxicity Grade 	Baseline Toxicity Grade 	
  Laboratory Test 	N 	Grade 0 	Grade 1 	Grade 2 	Grade 3 	Grade 4 	Total 	
Xanomeline High Dose 	53 	 	 	 	 	 	 	
Xanomeline Low Dose 	73 	 	 	 	 	 	 	
Placebo 	59 	 	 	 	 	 	 	
 	  	  	  	  	  	  	  	
Blood and lymphatic system disorders 	 	 	 	 	 	 	 	
Leukocytosis 	 	 	 	 	 	 	 	
Xanomeline High Dose 	53 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	53 	0 	0 	0 	0 	53 	
Grade 1 	 	0 	0 	0 	0 	0 	0 	
Grade 2 	 	0 	0 	0 	0 	0 	0 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	53 	0 	0 	0 	0 	53 	
 	 	 	 	 	 	 	 	
Xanomeline Low Dose 	73 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	73 	0 	0 	0 	0 	73 	
Grade 1 	 	0 	0 	0 	0 	0 	0 	
Grade 2 	 	0 	0 	0 	0 	0 	0 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	73 	0 	0 	0 	0 	73 	
 	 	 	 	 	 	 	 	
Placebo 	59 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	59 	0 	0 	0 	0 	59 	
Grade 1 	 	0 	0 	0 	0 	0 	0 	
Grade 2 	 	0 	0 	0 	0 	0 	0 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	59 	0 	0 	0 	0 	59 	
 	 	 	 	 	 	 	 	
Investigations 	 	 	 	 	 	 	 	
Alanine aminotransferase increased 	 	 	 	 	 	 	 	
Xanomeline High Dose 	53 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	49 	4 	0 	0 	0 	53 	
Grade 1 	 	5 	4 	0 	0 	0 	9 	
Grade 2 	 	1 	0 	0 	0 	0 	1 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	49 	4 	0 	0 	0 	53 	
 	 	 	 	 	 	 	 	
Xanomeline Low Dose 	73 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	70 	1 	0 	0 	0 	71 	
Grade 1 	 	7 	3 	0 	0 	0 	10 	
Grade 2 	 	0 	0 	0 	0 	0 	0 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	70 	3 	0 	0 	0 	73 	
 	 	 	 	 	 	 	 	
Placebo 	59 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	57 	2 	0 	0 	0 	59 	
Grade 1 	 	0 	2 	0 	0 	0 	2 	
Grade 2 	 	1 	0 	0 	0 	0 	1 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	57 	2 	0 	0 	0 	59 	
 	 	 	 	 	 	 	 	
Alkaline phosphatase increased 	 	 	 	 	 	 	 	
Xanomeline High Dose 	53 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	53 	0 	0 	0 	0 	53 	
Grade 1 	 	4 	0 	0 	0 	0 	4 	
Grade 2 	 	0 	0 	0 	0 	0 	0 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	53 	0 	0 	0 	0 	53 	
 	 	 	 	 	 	 	 	
Xanomeline Low Dose 	73 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	70 	1 	0 	0 	0 	71 	
Grade 1 	 	3 	3 	0 	0 	0 	6 	
Grade 2 	 	0 	0 	0 	0 	0 	0 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	70 	3 	0 	0 	0 	73 	
 	 	 	 	 	 	 	 	
Placebo 	59 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	59 	0 	0 	0 	0 	59 	
Grade 1 	 	4 	0 	0 	0 	0 	4 	
Grade 2 	 	1 	0 	0 	0 	0 	1 	
Grade 3 	 	1 	0 	0 	0 	0 	1 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	59 	0 	0 	0 	0 	59 	
 	 	 	 	 	 	 	 	
Aspartate aminotransferase increased 	 	 	 	 	 	 	 	
Xanomeline High Dose 	53 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	50 	3 	0 	0 	0 	53 	
Grade 1 	 	4 	3 	0 	0 	0 	7 	
Grade 2 	 	1 	0 	0 	0 	0 	1 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	50 	3 	0 	0 	0 	53 	
 	 	 	 	 	 	 	 	
Xanomeline Low Dose 	73 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	66 	4 	0 	0 	0 	70 	
Grade 1 	 	6 	7 	0 	0 	0 	13 	
Grade 2 	 	0 	1 	0 	0 	0 	1 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	66 	7 	0 	0 	0 	73 	
 	 	 	 	 	 	 	 	
Placebo 	59 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	57 	2 	0 	0 	0 	59 	
Grade 1 	 	4 	2 	0 	0 	0 	6 	
Grade 2 	 	1 	0 	0 	0 	0 	1 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	57 	2 	0 	0 	0 	59 	
 	 	 	 	 	 	 	 	
Blood bilirubin increased 	 	 	 	 	 	 	 	
Xanomeline High Dose 	53 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	51 	1 	1 	0 	0 	53 	
Grade 1 	 	1 	1 	1 	0 	0 	3 	
Grade 2 	 	0 	1 	1 	0 	0 	2 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	51 	1 	1 	0 	0 	53 	
 	 	 	 	 	 	 	 	
Xanomeline Low Dose 	73 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	70 	3 	0 	0 	0 	73 	
Grade 1 	 	1 	3 	0 	0 	0 	4 	
Grade 2 	 	0 	1 	0 	0 	0 	1 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	70 	3 	0 	0 	0 	73 	
 	 	 	 	 	 	 	 	
Placebo 	59 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	59 	0 	0 	0 	0 	59 	
Grade 1 	 	3 	0 	0 	0 	0 	3 	
Grade 2 	 	0 	0 	0 	0 	0 	0 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	59 	0 	0 	0 	0 	59 	
 	 	 	 	 	 	 	 	
Cholesterol high 	 	 	 	 	 	 	 	
Xanomeline High Dose 	53 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	51 	0 	2 	0 	0 	53 	
Grade 1 	 	3 	0 	0 	0 	0 	3 	
Grade 2 	 	0 	0 	2 	0 	0 	2 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	51 	0 	2 	0 	0 	53 	
 	 	 	 	 	 	 	 	
Xanomeline Low Dose 	73 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	73 	0 	0 	0 	0 	73 	
Grade 1 	 	1 	0 	0 	0 	0 	1 	
Grade 2 	 	2 	0 	0 	0 	0 	2 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	73 	0 	0 	0 	0 	73 	
 	 	 	 	 	 	 	 	
Placebo 	59 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	57 	0 	1 	0 	0 	58 	
Grade 1 	 	1 	0 	0 	0 	0 	1 	
Grade 2 	 	1 	0 	2 	0 	0 	3 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	57 	0 	2 	0 	0 	59 	
 	 	 	 	 	 	 	 	
Creatinine increased 	 	 	 	 	 	 	 	
Xanomeline High Dose 	53 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	49 	1 	0 	0 	0 	50 	
Grade 1 	 	42 	4 	0 	0 	0 	46 	
Grade 2 	 	0 	0 	0 	0 	0 	0 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	49 	4 	0 	0 	0 	53 	
 	 	 	 	 	 	 	 	
Xanomeline Low Dose 	73 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	68 	2 	0 	0 	0 	70 	
Grade 1 	 	41 	5 	0 	0 	0 	46 	
Grade 2 	 	0 	0 	0 	0 	0 	0 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	68 	5 	0 	0 	0 	73 	
 	 	 	 	 	 	 	 	
Placebo 	59 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	58 	1 	0 	0 	0 	59 	
Grade 1 	 	40 	1 	0 	0 	0 	41 	
Grade 2 	 	0 	0 	0 	0 	0 	0 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	58 	1 	0 	0 	0 	59 	
 	 	 	 	 	 	 	 	
Platelet count decreased 	 	 	 	 	 	 	 	
Xanomeline High Dose 	53 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	52 	1 	0 	0 	0 	53 	
Grade 1 	 	43 	1 	0 	0 	0 	44 	
Grade 2 	 	38 	0 	0 	0 	0 	38 	
Grade 3 	 	10 	0 	0 	0 	0 	10 	
Grade 4 	 	3 	0 	0 	0 	0 	3 	
Total 	 	52 	1 	0 	0 	0 	53 	
 	 	 	 	 	 	 	 	
Xanomeline Low Dose 	72 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	67 	2 	0 	0 	0 	69 	
Grade 1 	 	48 	1 	0 	0 	0 	49 	
Grade 2 	 	35 	1 	0 	0 	0 	36 	
Grade 3 	 	25 	0 	0 	0 	0 	25 	
Grade 4 	 	1 	0 	0 	0 	0 	1 	
Total 	 	70 	2 	0 	0 	0 	72 	
 	 	 	 	 	 	 	 	
Placebo 	59 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	59 	0 	0 	0 	0 	59 	
Grade 1 	 	52 	0 	0 	0 	0 	52 	
Grade 2 	 	37 	0 	0 	0 	0 	37 	
Grade 3 	 	22 	0 	0 	0 	0 	22 	
Grade 4 	 	1 	0 	0 	0 	0 	1 	
Total 	 	59 	0 	0 	0 	0 	59 	
 	 	 	 	 	 	 	 	
White blood cell decreased 	 	 	 	 	 	 	 	
Xanomeline High Dose 	53 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	53 	0 	0 	0 	0 	53 	
Grade 1 	 	45 	0 	0 	0 	0 	45 	
Grade 2 	 	33 	0 	0 	0 	0 	33 	
Grade 3 	 	18 	0 	0 	0 	0 	18 	
Grade 4 	 	1 	0 	0 	0 	0 	1 	
Total 	 	53 	0 	0 	0 	0 	53 	
 	 	 	 	 	 	 	 	
Xanomeline Low Dose 	73 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	67 	3 	0 	0 	0 	70 	
Grade 1 	 	50 	3 	0 	0 	0 	53 	
Grade 2 	 	32 	1 	0 	0 	0 	33 	
Grade 3 	 	21 	0 	0 	0 	0 	21 	
Grade 4 	 	1 	0 	0 	0 	0 	1 	
Total 	 	70 	3 	0 	0 	0 	73 	
 	 	 	 	 	 	 	 	
Placebo 	59 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	59 	0 	0 	0 	0 	59 	
Grade 1 	 	52 	0 	0 	0 	0 	52 	
Grade 2 	 	42 	0 	0 	0 	0 	42 	
Grade 3 	 	21 	0 	0 	0 	0 	21 	
Grade 4 	 	4 	0 	0 	0 	0 	4 	
Total 	 	59 	0 	0 	0 	0 	59 	
 	 	 	 	 	 	 	 	
Metabolism and nutritional disorders 	 	 	 	 	 	 	 	
CD4 lymphocytes decreased 	 	 	 	 	 	 	 	
Xanomeline High Dose 	51 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	51 	0 	0 	0 	0 	51 	
Grade 1 	 	47 	0 	0 	0 	0 	47 	
Grade 2 	 	28 	0 	0 	0 	0 	28 	
Grade 3 	 	15 	0 	0 	0 	0 	15 	
Grade 4 	 	6 	0 	0 	0 	0 	6 	
Total 	 	51 	0 	0 	0 	0 	51 	
 	 	 	 	 	 	 	 	
Xanomeline Low Dose 	72 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	66 	2 	0 	0 	0 	68 	
Grade 1 	 	46 	1 	0 	0 	0 	47 	
Grade 2 	 	37 	0 	0 	0 	0 	37 	
Grade 3 	 	18 	0 	0 	0 	0 	18 	
Grade 4 	 	3 	1 	0 	0 	0 	4 	
Total 	 	70 	2 	0 	0 	0 	72 	
 	 	 	 	 	 	 	 	
Placebo 	57 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	56 	1 	0 	0 	0 	57 	
Grade 1 	 	48 	1 	0 	0 	0 	49 	
Grade 2 	 	43 	1 	0 	0 	0 	44 	
Grade 3 	 	27 	0 	0 	0 	0 	27 	
Grade 4 	 	3 	0 	0 	0 	0 	3 	
Total 	 	56 	1 	0 	0 	0 	57 	
 	 	 	 	 	 	 	 	
Hyperglycemia 	 	 	 	 	 	 	 	
Xanomeline High Dose 	53 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	53 	0 	0 	0 	0 	53 	
Grade 1 	 	0 	0 	0 	0 	0 	0 	
Grade 2 	 	0 	0 	0 	0 	0 	0 	
Grade 3 	 	6 	0 	0 	0 	0 	6 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	53 	0 	0 	0 	0 	53 	
 	 	 	 	 	 	 	 	
Xanomeline Low Dose 	73 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	73 	0 	0 	0 	0 	73 	
Grade 1 	 	0 	0 	0 	0 	0 	0 	
Grade 2 	 	0 	0 	0 	0 	0 	0 	
Grade 3 	 	1 	0 	0 	0 	0 	1 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	73 	0 	0 	0 	0 	73 	
 	 	 	 	 	 	 	 	
Placebo 	59 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	59 	0 	0 	0 	0 	59 	
Grade 1 	 	0 	0 	0 	0 	0 	0 	
Grade 2 	 	0 	0 	0 	0 	0 	0 	
Grade 3 	 	1 	0 	0 	0 	0 	1 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	59 	0 	0 	0 	0 	59 	
 	 	 	 	 	 	 	 	
Hyperkalemia 	 	 	 	 	 	 	 	
Xanomeline High Dose 	53 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	53 	0 	0 	0 	0 	53 	
Grade 1 	 	1 	0 	0 	0 	0 	1 	
Grade 2 	 	1 	0 	0 	0 	0 	1 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	53 	0 	0 	0 	0 	53 	
 	 	 	 	 	 	 	 	
Xanomeline Low Dose 	73 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	73 	0 	0 	0 	0 	73 	
Grade 1 	 	0 	0 	0 	0 	0 	0 	
Grade 2 	 	0 	0 	0 	0 	0 	0 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	73 	0 	0 	0 	0 	73 	
 	 	 	 	 	 	 	 	
Placebo 	59 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	58 	0 	1 	0 	0 	59 	
Grade 1 	 	0 	0 	1 	0 	0 	1 	
Grade 2 	 	0 	0 	1 	0 	0 	1 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	58 	0 	1 	0 	0 	59 	
 	 	 	 	 	 	 	 	
Hypernatremia 	 	 	 	 	 	 	 	
Xanomeline High Dose 	53 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	51 	2 	0 	0 	0 	53 	
Grade 1 	 	5 	2 	0 	0 	0 	7 	
Grade 2 	 	2 	0 	0 	0 	0 	2 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	51 	2 	0 	0 	0 	53 	
 	 	 	 	 	 	 	 	
Xanomeline Low Dose 	73 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	73 	0 	0 	0 	0 	73 	
Grade 1 	 	6 	0 	0 	0 	0 	6 	
Grade 2 	 	0 	0 	0 	0 	0 	0 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	73 	0 	0 	0 	0 	73 	
 	 	 	 	 	 	 	 	
Placebo 	59 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	56 	3 	0 	0 	0 	59 	
Grade 1 	 	7 	3 	0 	0 	0 	10 	
Grade 2 	 	0 	0 	0 	0 	0 	0 	
Grade 3 	 	0 	0 	0 	0 	0 	0 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	56 	3 	0 	0 	0 	59 	
 	 	 	 	 	 	 	 	
Hypoalbuminemia 	 	 	 	 	 	 	 	
Xanomeline High Dose 	53 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	53 	0 	0 	0 	0 	53 	
Grade 1 	 	48 	0 	0 	0 	0 	48 	
Grade 2 	 	34 	0 	0 	0 	0 	34 	
Grade 3 	 	23 	0 	0 	0 	0 	23 	
Grade 4 	 	2 	0 	0 	0 	0 	2 	
Total 	 	53 	0 	0 	0 	0 	53 	
 	 	 	 	 	 	 	 	
Xanomeline Low Dose 	73 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	69 	2 	0 	0 	0 	71 	
Grade 1 	 	50 	2 	0 	0 	0 	52 	
Grade 2 	 	41 	0 	0 	0 	0 	41 	
Grade 3 	 	19 	0 	0 	0 	0 	19 	
Grade 4 	 	2 	0 	0 	0 	0 	2 	
Total 	 	71 	2 	0 	0 	0 	73 	
 	 	 	 	 	 	 	 	
Placebo 	59 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	59 	0 	0 	0 	0 	59 	
Grade 1 	 	49 	0 	0 	0 	0 	49 	
Grade 2 	 	40 	0 	0 	0 	0 	40 	
Grade 3 	 	21 	0 	0 	0 	0 	21 	
Grade 4 	 	3 	0 	0 	0 	0 	3 	
Total 	 	59 	0 	0 	0 	0 	59 	
 	 	 	 	 	 	 	 	
Hypoglycemia 	 	 	 	 	 	 	 	
Xanomeline High Dose 	53 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	53 	0 	0 	0 	0 	53 	
Grade 1 	 	41 	0 	0 	0 	0 	41 	
Grade 2 	 	38 	0 	0 	0 	0 	38 	
Grade 3 	 	21 	0 	0 	0 	0 	21 	
Grade 4 	 	5 	0 	0 	0 	0 	5 	
Total 	 	53 	0 	0 	0 	0 	53 	
 	 	 	 	 	 	 	 	
Xanomeline Low Dose 	73 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	69 	0 	1 	0 	0 	70 	
Grade 1 	 	50 	0 	0 	0 	0 	50 	
Grade 2 	 	35 	0 	0 	0 	0 	35 	
Grade 3 	 	25 	0 	0 	0 	0 	25 	
Grade 4 	 	2 	0 	0 	0 	0 	2 	
Total 	 	71 	0 	1 	0 	0 	72 	
 	 	 	 	 	 	 	 	
Placebo 	59 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	58 	0 	0 	0 	0 	58 	
Grade 1 	 	55 	0 	0 	0 	0 	55 	
Grade 2 	 	37 	0 	0 	0 	0 	37 	
Grade 3 	 	23 	0 	0 	0 	0 	23 	
Grade 4 	 	3 	0 	0 	0 	0 	3 	
Total 	 	59 	0 	0 	0 	0 	59 	
 	 	 	 	 	 	 	 	
Hypokalemia 	 	 	 	 	 	 	 	
Xanomeline High Dose 	53 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	53 	0 	0 	0 	0 	53 	
Grade 1 	 	45 	0 	0 	0 	0 	45 	
Grade 2 	 	38 	0 	0 	0 	0 	38 	
Grade 3 	 	25 	0 	0 	0 	0 	25 	
Grade 4 	 	5 	0 	0 	0 	0 	5 	
Total 	 	53 	0 	0 	0 	0 	53 	
 	 	 	 	 	 	 	 	
Xanomeline Low Dose 	73 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	71 	0 	0 	0 	0 	71 	
Grade 1 	 	49 	0 	0 	0 	0 	49 	
Grade 2 	 	38 	0 	0 	0 	0 	38 	
Grade 3 	 	23 	0 	0 	0 	0 	23 	
Grade 4 	 	6 	0 	0 	0 	0 	6 	
Total 	 	73 	0 	0 	0 	0 	73 	
 	 	 	 	 	 	 	 	
Placebo 	59 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	57 	0 	0 	0 	0 	57 	
Grade 1 	 	51 	0 	0 	0 	0 	51 	
Grade 2 	 	38 	0 	0 	0 	0 	38 	
Grade 3 	 	28 	0 	0 	0 	0 	28 	
Grade 4 	 	4 	0 	0 	0 	0 	4 	
Total 	 	59 	0 	0 	0 	0 	59 	
 	 	 	 	 	 	 	 	
Hyponatremia 	 	 	 	 	 	 	 	
Xanomeline High Dose 	53 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	53 	0 	0 	0 	0 	53 	
Grade 1 	 	47 	0 	0 	0 	0 	47 	
Grade 2 	 	36 	0 	0 	0 	0 	36 	
Grade 3 	 	21 	0 	0 	0 	0 	21 	
Grade 4 	 	5 	0 	0 	0 	0 	5 	
Total 	 	53 	0 	0 	0 	0 	53 	
 	 	 	 	 	 	 	 	
Xanomeline Low Dose 	73 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	64 	2 	0 	0 	0 	66 	
Grade 1 	 	52 	1 	0 	0 	0 	53 	
Grade 2 	 	36 	1 	0 	0 	0 	37 	
Grade 3 	 	28 	0 	0 	0 	0 	28 	
Grade 4 	 	1 	0 	0 	0 	0 	1 	
Total 	 	71 	2 	0 	0 	0 	73 	
 	 	 	 	 	 	 	 	
Placebo 	59 	 	 	 	 	 	 	
Worst toxicity grade, n 	 	 	 	 	 	 	 	
Grade 0 	 	58 	1 	0 	0 	0 	59 	
Grade 1 	 	50 	1 	0 	0 	0 	51 	
Grade 2 	 	39 	1 	0 	0 	0 	40 	
Grade 3 	 	25 	0 	0 	0 	0 	25 	
Grade 4 	 	0 	0 	0 	0 	0 	0 	
Total 	 	58 	1 	0 	0 	0 	59 	

Note: N is the number of subjects with non-missing values for the specific lab test at baseline and at least 1 postbaseline visit within the time period. 	
Note: N is the number of subjects with non-missing values for the specific lab test at baseline and at least 1 postbaseline visit within the time period.	
Note: N is the number of subjects with non-missing values for the specific lab test at baseline and at least 1 postbaseline visit within the time period.	
Note: N is the number of subjects with non-missing values for the specific lab test at baseline and at least 1 postbaseline visit within the time period.	
Note: N is the number of subjects with non-missing values for the specific lab test at baseline and at least 1 postbaseline visit within the time period.	
Note: N is the number of subjects with non-missing values for the specific lab test at baseline and at least 1 postbaseline visit within the time period.	
Note: N is the number of subjects with non-missing values for the specific lab test at baseline and at least 1 postbaseline visit within the time period.	
Note: N is the number of subjects with non-missing values for the specific lab test at baseline and at least 1 postbaseline visit within the time period.	
Note: NCI-CTCAE grades (version 5.0.) are based on the laboratory result and do not take into account the clinical component, if applicable. 	: NCI-CTCAE grades (version 5.) are based on the laboratory result and do not take into account the clinical component, if applicable.	: NCI-CTCAE grades (version 5.) are based on the laboratory result and do not take into account the clinical component, if applicable.	: NCI-CTCAE grades (version 5.) are based on the laboratory result and do not take into account the clinical component, if applicable.	: NCI-CTCAE grades (version 5.) are based on the laboratory result and do not take into account the clinical component, if applicable.	: NCI-CTCAE grades (version 5.) are based on the laboratory result and do not take into account the clinical component, if applicable.	: NCI-CTCAE grades (version 5.) are based on the laboratory result and do not take into account the clinical component, if applicable.	: NCI-CTCAE grades (version 5.) are based on the laboratory result and do not take into account the clinical component, if applicable.