TSIDEM01:	Demographics and Baseline Characteristics; Full Analysis Set (Study jjcs - core)					
 	Active Study Agent 	Active Study Agent 	 	 	
 	Xanomeline High Dose 	Xanomeline Low Dose 	Placebo 	Total 	
Characteristic 	N=84 	N=84 	N=86 	N=254 	
Sex, n (%) 	 	 	 	 	
N 	84 	84 	86 	254 	
Male 	44 (52.4%) 	34 (40.5%) 	33 (38.4%) 	111 (43.7%) 	
Female 	40 (47.6%) 	50 (59.5%) 	53 (61.6%) 	143 (56.3%) 	
Intersex 	0 	0 	0 	0 	
Unknown 	0 	0 	0 	0 	
 	 	 	 	 	
Age 	 	 	 	 	
N 	84 	84 	86 	254 	
Mean (SD) 	74.4 (7.89) 	75.7 (8.29) 	75.2 (8.59) 	75.1 (8.25) 	
Median 	76.0 	77.5 	76.0 	77.0 	
Min, max 	56, 88 	51, 88 	52, 89 	51, 89 	
≥18 to <65, n (%) 	11 (13.1%) 	8 (9.5%) 	14 (16.3%) 	33 (13.0%) 	
≥65, n (%) 	73 (86.9%) 	76 (90.5%) 	72 (83.7%) 	221 (87.0%) 	
≥65 to <75, n (%) 	25 (29.8%) 	23 (27.4%) 	24 (27.9%) 	72 (28.3%) 	
≥75, n (%) 	48 (57.1%) 	53 (63.1%) 	48 (55.8%) 	149 (58.7%) 	
 	 	 	 	 	
Race, n (%) 	 	 	 	 	
N 	84 	84 	86 	254 	
American Indian or Alaska Native 	7 (8.3%) 	13 (15.5%) 	6 (7.0%) 	26 (10.2%) 	
Asian 	11 (13.1%) 	11 (13.1%) 	7 (8.1%) 	29 (11.4%) 	
Black or African American 	7 (8.3%) 	10 (11.9%) 	10 (11.6%) 	27 (10.6%) 	
Native Hawaiian or other Pacific Islander 	10 (11.9%) 	7 (8.3%) 	8 (9.3%) 	25 (9.8%) 	
White 	11 (13.1%) 	10 (11.9%) 	9 (10.5%) 	30 (11.8%) 	
Multiple 	12 (14.3%) 	9 (10.7%) 	8 (9.3%) 	29 (11.4%) 	
Not reported 	11 (13.1%) 	7 (8.3%) 	11 (12.8%) 	29 (11.4%) 	
Unknown 	10 (11.9%) 	6 (7.1%) 	11 (12.8%) 	27 (10.6%) 	
Other 	5 (6.0%) 	11 (13.1%) 	16 (18.6%) 	32 (12.6%) 	
 	 	 	 	 	
Ethnicity, n (%) 	 	 	 	 	
N 	84 	84 	86 	254 	
Hispanic or Latino 	20 (23.8%) 	19 (22.6%) 	18 (20.9%) 	57 (22.4%) 	
Not Hispanic or Latino 	26 (31.0%) 	18 (21.4%) 	19 (22.1%) 	63 (24.8%) 	
Not reported 	15 (17.9%) 	27 (32.1%) 	23 (26.7%) 	65 (25.6%) 	
Unknown 	23 (27.4%) 	20 (23.8%) 	26 (30.2%) 	69 (27.2%) 	
 	 	 	 	 	
Weight (kg) 	 	 	 	 	
N 	84 	84 	86 	254 	
Mean (SD) 	73.00 (44.004) 	75.88 (43.448) 	76.66 (42.980) 	75.19 (43.332) 	
Median 	75.50 	73.00 	74.00 	74.50 	
Min, max 	3.0, 149.0 	1.0, 147.0 	1.0, 150.0 	1.0, 150.0 	
<30, n (%) 	22 (26.2%) 	17 (20.2%) 	13 (15.1%) 	52 (20.5%) 	
≥30 to <60, n (%) 	10 (11.9%) 	14 (16.7%) 	20 (23.3%) 	44 (17.3%) 	
≥60 to <90, n (%) 	17 (20.2%) 	18 (21.4%) 	20 (23.3%) 	55 (21.7%) 	
≥90, n (%) 	35 (41.7%) 	35 (41.7%) 	33 (38.4%) 	103 (40.6%) 	
 	 	 	 	 	
Height (cm) 	 	 	 	 	
N 	84 	84 	86 	254 	
Mean (SD) 	65.19 (42.011) 	86.35 (47.899) 	67.51 (43.173) 	72.97 (45.249) 	
Median 	62.50 	96.00 	68.00 	70.50 	
Min, max 	1.0, 143.0 	1.0, 150.0 	0.0, 150.0 	0.0, 150.0 	
 	 	 	 	 	
Body mass index (kg/m2) 	 	 	 	 	
N 	84 	84 	86 	254 	
Mean (SD) 	79.63 (45.793) 	78.55 (46.331) 	70.19 (42.088) 	76.07 (44.781) 	
Median 	78.00 	84.00 	63.50 	75.50 	
Min, max 	1.0, 150.0 	4.0, 150.0 	2.0, 148.0 	1.0, 150.0 	
Underweight <18.5, n (%) 	11 (13.1%) 	12 (14.3%) 	13 (15.1%) 	36 (14.2%) 	
Normal ≥18.5 to <25, n (%) 	4 (4.8%) 	1 (1.2%) 	1 (1.2%) 	6 (2.4%) 	
Overweight ≥25 to <30, n (%) 	2 (2.4%) 	6 (7.1%) 	2 (2.3%) 	10 (3.9%) 	
Obese ≥30, n (%) 	67 (79.8%) 	65 (77.4%) 	70 (81.4%) 	202 (79.5%) 	
 	 	 	 	 	
Body surface area (m2) 	 	 	 	 	
N 	84 	84 	86 	254 	
Mean (SD) 	70.15 (38.549) 	80.58 (38.458) 	80.12 (47.211) 	76.98 (41.769) 	
Median 	69.50 	87.50 	79.50 	76.00 	
Min, max 	6.0, 150.0 	3.0, 146.0 	2.0, 150.0 	2.0, 150.0 	
 	 	 	 	 	
Geographic Region 1, n (%) 	 	 	 	 	
N 	84 	84 	86 	254 	
NA 	84 (100.0%) 	84 (100.0%) 	86 (100.0%) 	254 (100.0%) 	
 	 	 	 	 	
Country/Territory, n (%) 	 	 	 	 	
N 	84 	84 	86 	254 	
United States of America 	84 (100.0%) 	84 (100.0%) 	86 (100.0%) 	254 (100.0%)