TSIEX04:	Number of Cycles Received; Safety Analysis Set (Study jjcs - core)					
 	Active Study Agent 	Active Study Agent 	Active Study Agent 	 	
 	Xanomeline High Dose 	Xanomeline Low Dose 	Combined 	Placebo 	
Parameter 	N=53 	N=73 	N=126 	N=59 	
Total number of cycles received 	 	 	 	 	
N 	53 	73 	126 	59 	
Mean (SD) 	12.1 (7.40) 	12.9 (6.50) 	12.5 (6.88) 	12.0 (7.44) 	
Median 	12.0 	13.0 	13.0 	12.0 	
Min, max 	0, 24 	0, 24 	0, 24 	0, 24 	
 	 	 	 	 	
Total number of cycles received, n (%) 	 	 	 	 	
1 to <10 	19 (37.3%) 	21 (29.6%) 	40 (32.8%) 	24 (42.1%) 	
10 to <20 	21 (41.2%) 	35 (49.3%) 	56 (45.9%) 	21 (36.8%) 	
≥20 	11 (21.6%) 	15 (21.1%) 	26 (21.3%) 	12 (21.1%) 	
 	 	 	 	 	
Total number of cycles receiveda, n (%) 	 	 	 	 	
≥1 	51 (96.2%) 	71 (97.3%) 	122 (96.8%) 	57 (96.6%) 	
≥2 	49 (92.5%) 	69 (94.5%) 	118 (93.7%) 	56 (94.9%) 	
≥3 	46 (86.8%) 	69 (94.5%) 	115 (91.3%) 	54 (91.5%) 	
≥5 	43 (81.1%) 	66 (90.4%) 	109 (86.5%) 	48 (81.4%) 	
≥10 	32 (60.4%) 	50 (68.5%) 	82 (65.1%) 	33 (55.9%) 	

a Subjects are summarized in all applicable cycle categories. 	
a Subjects are summarized in all applicable cycle categories.	
a Subjects are summarized in all applicable cycle categories.	
a Subjects are summarized in all applicable cycle categories.	
a Subjects are summarized in all applicable cycle categories.