TSIEX07:	Dose Levels Over Time; Safety Analysis Set (Study jjcs - core)									
 	Active Study Agent 	Active Study Agent 	Active Study Agent 	Active Study Agent 	Active Study Agent 	Active Study Agent 	Active Study Agent 	 	
 	60 	120 	240 	300 	480 	720 	960 	Total 	
Time Point, n (%) 	N=3 	N=3 	N=3 	N=8 	N=26 	N=98 	N=51 	N=125 	
Baseline 	1 (33.3%) 	2 (66.7%) 	3 (100.0%) 	3 (37.5%) 	13 (50.0%) 	94 (95.9%) 	9 (17.6%) 	125 (100.0%) 	
Week 2 	1 (33.3%) 	1 (33.3%) 	0 	3 (37.5%) 	3 (11.5%) 	2 (2.0%) 	41 (80.4%) 	104 (83.2%) 	
Week 24 	2 (66.7%) 	0 	0 	2 (25.0%) 	12 (46.2%) 	17 (17.3%) 	2 (3.9%) 	35 (28.0%)