TPK01a:	[Matrix] [Active Study Agent/Analyte] Concentrations ([units]) Over Time; Pharmacokinetics Analysis Set (Study jjcs - core)				
 	Active Study Agent 	Active Study Agent 	Active Study Agent 	
 	Xanomeline High Dose 	Xanomeline Low Dose 	Combined 	
Time Point 	N=72 	N=96 	N=168 	
Day 1 - Pre-dose 	 	 	 	
N 	72 	96 	168 	
Mean (SD) 	0.00 (0.00) 	0.00 (0.00) 	0.00 (0.00) 	
Median 	0.00 	0.00 	0.00 	
Geometric mean 	NA 	NA 	NA 	
Min, max 	0.00, 0.00 	0.00, 0.00 	0.00, 0.00 	
CV (%) 	NA 	NA 	NA 	
Interquartile range 	0.00, 0.00 	0.00, 0.00 	0.00, 0.00 	
 	 	 	 	
Day 1 - 5 Min Post-dose 	 	 	 	
N 	72 	96 	168 	
Mean (SD) 	0.10 (0.00) 	0.10 (0.01) 	0.10 (0.01) 	
Median 	0.10 	0.10 	0.10 	
Geometric mean 	0.10 	0.10 	0.10 	
Min, max 	0.09, 0.11 	0.09, 0.11 	0.09, 0.11 	
CV (%) 	4.9 	5.3 	5.1 	
Interquartile range 	0.10, 0.10 	0.10, 0.10 	0.10, 0.10 	
 	 	 	 	
Day 1 - 30 Min Post-dose 	 	 	 	
N 	72 	96 	168 	
Mean (SD) 	0.54 (0.02) 	0.55 (0.03) 	0.55 (0.03) 	
Median 	0.54 	0.54 	0.54 	
Geometric mean 	0.54 	0.55 	0.54 	
Min, max 	0.50, 0.60 	0.50, 0.60 	0.50, 0.60 	
CV (%) 	4.4 	4.8 	4.6 	
Interquartile range 	0.52, 0.56 	0.53, 0.57 	0.52, 0.56 	
 	 	 	 	
Day 1 - 1h Post-dose 	 	 	 	
N 	72 	96 	168 	
Mean (SD) 	0.93 (0.04) 	0.93 (0.04) 	0.93 (0.04) 	
Median 	0.93 	0.93 	0.93 	
Geometric mean 	0.93 	0.93 	0.93 	
Min, max 	0.86, 1.02 	0.85, 1.01 	0.85, 1.02 	
CV (%) 	4.0 	4.4 	4.2 	
Interquartile range 	0.90, 0.95 	0.90, 0.96 	0.90, 0.96 	
 	 	 	 	
Day 1 - 1.5h Post-dose 	 	 	 	
N 	72 	96 	168 	
Mean (SD) 	1.20 (0.04) 	1.20 (0.05) 	1.20 (0.05) 	
Median 	1.20 	1.20 	1.20 	
Geometric mean 	1.20 	1.20 	1.20 	
Min, max 	1.12, 1.31 	1.11, 1.29 	1.11, 1.31 	
CV (%) 	3.7 	4.0 	3.9 	
Interquartile range 	1.17, 1.22 	1.16, 1.24 	1.17, 1.23 	
 	 	 	 	
Day 1 - 2h Post-dose 	 	 	 	
N 	72 	96 	168 	
Mean (SD) 	1.39 (0.05) 	1.39 (0.05) 	1.39 (0.05) 	
Median 	1.38 	1.39 	1.39 	
Geometric mean 	1.39 	1.39 	1.39 	
Min, max 	1.31, 1.50 	1.29, 1.49 	1.29, 1.50 	
CV (%) 	3.4 	3.7 	3.6 	
Interquartile range 	1.36, 1.41 	1.35, 1.43 	1.35, 1.43 	
 	 	 	 	
Day 1 - 4h Post-dose 	 	 	 	
N 	72 	96 	168 	
Mean (SD) 	1.73 (0.05) 	1.74 (0.05) 	1.74 (0.05) 	
Median 	1.73 	1.74 	1.73 	
Geometric mean 	1.73 	1.74 	1.73 	
Min, max 	1.65, 1.84 	1.64, 1.83 	1.64, 1.84 	
CV (%) 	3.0 	3.2 	3.1 	
Interquartile range 	1.69, 1.78 	1.69, 1.79 	1.69, 1.78 	
 	 	 	 	
Day 1 - 0-6h Post-dose 	 	 	 	
N 	72 	96 	168 	
Mean (SD) 	26.85 (1.51) 	26.72 (1.44) 	26.78 (1.47) 	
Median 	26.80 	26.63 	26.67 	
Geometric mean 	26.81 	26.68 	26.74 	
Min, max 	24.49, 29.19 	24.53, 29.25 	24.49, 29.25 	
CV (%) 	5.6 	5.4 	5.5 	
Interquartile range 	25.46, 28.28 	25.56, 28.01 	25.52, 28.17 	
 	 	 	 	
Day 1 - 6h Post-dose 	 	 	 	
N 	72 	96 	168 	
Mean (SD) 	1.82 (0.05) 	1.82 (0.05) 	1.82 (0.05) 	
Median 	1.82 	1.82 	1.82 	
Geometric mean 	1.82 	1.82 	1.82 	
Min, max 	1.74, 1.92 	1.73, 1.91 	1.73, 1.92 	
CV (%) 	3.0 	3.0 	3.0 	
Interquartile range 	1.77, 1.87 	1.77, 1.88 	1.77, 1.87 	
 	 	 	 	
Day 1 - 8h Post-dose 	 	 	 	
N 	72 	96 	168 	
Mean (SD) 	1.84 (0.05) 	1.84 (0.05) 	1.84 (0.05) 	
Median 	1.84 	1.84 	1.84 	
Geometric mean 	1.84 	1.84 	1.84 	
Min, max 	1.76, 1.94 	1.75, 1.94 	1.75, 1.94 	
CV (%) 	3.0 	3.0 	3.0 	
Interquartile range 	1.79, 1.90 	1.79, 1.90 	1.79, 1.90 	
 	 	 	 	
Day 1 - 6-12h Post-dose 	 	 	 	
N 	72 	96 	168 	
Mean (SD) 	22.67 (1.69) 	22.52 (1.61) 	22.58 (1.64) 	
Median 	22.62 	22.43 	22.47 	
Geometric mean 	22.60 	22.47 	22.53 	
Min, max 	20.01, 25.27 	20.06, 25.34 	20.01, 25.34 	
CV (%) 	7.4 	7.1 	7.3 	
Interquartile range 	21.11, 24.26 	21.23, 23.97 	21.18, 24.15 	
 	 	 	 	
Day 1 - 12h Post-dose 	 	 	 	
N 	72 	96 	168 	
Mean (SD) 	0.55 (0.03) 	0.55 (0.03) 	0.55 (0.03) 	
Median 	0.55 	0.55 	0.55 	
Geometric mean 	0.55 	0.55 	0.55 	
Min, max 	0.49, 0.62 	0.49, 0.62 	0.49, 0.62 	
CV (%) 	6.2 	5.4 	5.7 	
Interquartile range 	0.53, 0.58 	0.53, 0.57 	0.53, 0.57 	
 	 	 	 	
Day 1 - 16h Post-dose 	 	 	 	
N 	72 	96 	168 	
Mean (SD) 	0.16 (0.02) 	0.16 (0.02) 	0.16 (0.02) 	
Median 	0.17 	0.16 	0.16 	
Geometric mean 	0.16 	0.16 	0.16 	
Min, max 	0.13, 0.20 	0.13, 0.20 	0.13, 0.20 	
CV (%) 	11.0 	10.0 	10.4 	
Interquartile range 	0.15, 0.18 	0.15, 0.18 	0.15, 0.18 	
 	 	 	 	
Day 1 - 12-24h Post-dose 	 	 	 	
N 	72 	96 	168 	
Mean (SD) 	14.30 (2.04) 	14.13 (1.95) 	14.20 (1.99) 	
Median 	14.26 	14.02 	14.07 	
Geometric mean 	14.15 	13.99 	14.06 	
Min, max 	11.07, 17.44 	11.13, 17.52 	11.07, 17.52 	
CV (%) 	14.3 	13.8 	14.0 	
Interquartile range 	12.41, 16.24 	12.56, 15.88 	12.50, 16.10 	
 	 	 	 	
Day 2 - 24h Post-dose 	 	 	 	
N 	72 	96 	168 	
Mean (SD) 	0.01 (0.00) 	0.01 (0.00) 	0.01 (0.00) 	
Median 	0.01 	0.01 	0.01 	
Geometric mean 	0.01 	0.01 	0.01 	
Min, max 	0.01, 0.02 	0.01, 0.02 	0.01, 0.02 	
CV (%) 	20.9 	19.7 	20.2 	
Interquartile range 	0.01, 0.02 	0.01, 0.02 	0.01, 0.02 	
 	 	 	 	
Day 2 - Pre-dose 	 	 	 	
N 	72 	94 	166 	
Mean (SD) 	0.01 (0.00) 	0.01 (0.00) 	0.01 (0.00) 	
Median 	0.01 	0.01 	0.01 	
Geometric mean 	0.01 	0.01 	0.01 	
Min, max 	0.01, 0.02 	0.01, 0.02 	0.01, 0.02 	
CV (%) 	20.9 	19.7 	20.2 	
Interquartile range 	0.01, 0.02 	0.01, 0.02 	0.01, 0.02 	
 	 	 	 	
Day 2 - 36h Post-dose 	 	 	 	
N 	72 	96 	168 	
Mean (SD) 	0.00 (0.00) 	0.00 (0.00) 	0.00 (0.00) 	
Median 	0.00 	0.00 	0.00 	
Geometric mean 	0.01 	0.01 	0.01 	
Min, max 	0.00, 0.00 	0.00, 0.00 	0.00, 0.00 	
CV (%) 	0.0 	0.0 	0.0 	
Interquartile range 	0.00, 0.00 	0.00, 0.00 	0.00, 0.00 	
 	 	 	 	
Day 2 - 24-48h Post-dose 	 	 	 	
N 	72 	96 	168 	
Mean (SD) 	0.28 (0.53) 	0.22 (0.49) 	0.25 (0.50) 	
Median 	0.00 	0.00 	0.00 	
Geometric mean 	0.02 	0.01 	0.02 	
Min, max 	0.00, 1.78 	0.00, 1.89 	0.00, 1.89 	
CV (%) 	191.0 	217.2 	204.4 	
Interquartile range 	0.00, 0.18 	0.00, 0.00 	0.00, 0.00 	
 	 	 	 	
Day 3 - 48h Post-dose 	 	 	 	
N 	72 	96 	168 	
Mean (SD) 	0.00 (0.00) 	0.00 (0.00) 	0.00 (0.00) 	
Median 	0.00 	0.00 	0.00 	
Geometric mean 	0.01 	0.01 	0.01 	
Min, max 	0.00, 0.00 	0.00, 0.00 	0.00, 0.00 	
CV (%) 	0.0 	0.0 	0.0 	
Interquartile range 	0.00, 0.00 	0.00, 0.00 	0.00, 0.00 	
 	 	 	 	
Day 3 - Pre-dose 	 	 	 	
N 	72 	92 	164 	
Mean (SD) 	0.00 (0.00) 	0.00 (0.00) 	0.00 (0.00) 	
Median 	0.00 	0.00 	0.00 	
Geometric mean 	0.01 	0.01 	0.01 	
Min, max 	0.00, 0.00 	0.00, 0.00 	0.00, 0.00 	
CV (%) 	0.0 	0.0 	0.0 	
Interquartile range 	0.00, 0.00 	0.00, 0.00 	0.00, 0.00 	

Note: Incongruous samples are not included in this summary. 	
Note: Incongruous samples are not included in this summary.	
Note: Incongruous samples are not included in this summary.	
Note: Incongruous samples are not included in this summary.	
Note: Concentrations below the lowest quantifiable concentration (ie, [x.xx ng/mL]) will be treated as zero in calculating the summary statistics. 	: Concentrations below the lowest quantifiable concentration (ie, [x.xx ng/mL]) will be treated as zero in calculating the summary statistics.	: Concentrations below the lowest quantifiable concentration (ie, [x.xx ng/mL]) will be treated as zero in calculating the summary statistics.	: Concentrations below the lowest quantifiable concentration (ie, [x.xx ng/mL]) will be treated as zero in calculating the summary statistics.