TPK03:	Subjects With [Matrix] [Active Study Agent/Analyte] Concentrations Below the Lowest Quantification Level ([LLOQ/LLOQxMRD and units]) Over Time; Pharmacokinetics Analysis Set (Study jjcs - core)				
 	Active Study Agent 	Active Study Agent 	Active Study Agent 	
 	Xanomeline High Dose 	Xanomeline Low Dose 	Combined 	
Time Point 	N=72 	N=96 	N=168 	
Day 1 - Pre-dose 	 	 	 	
N 	72 	96 	168 	
Number of subjects with values below LLOQxMRD, n (%) 	72 (100.0%) 	96 (100.0%) 	168 (100.0%) 	
 	 	 	 	
Day 1 - 5 Min Post-dose 	 	 	 	
N 	72 	96 	168 	
Number of subjects with values below LLOQxMRD, n (%) 	0 	0 	0 	
 	 	 	 	
Day 1 - 30 Min Post-dose 	 	 	 	
N 	72 	96 	168 	
Number of subjects with values below LLOQxMRD, n (%) 	0 	0 	0 	
 	 	 	 	
Day 1 - 1h Post-dose 	 	 	 	
N 	72 	96 	168 	
Number of subjects with values below LLOQxMRD, n (%) 	0 	0 	0 	
 	 	 	 	
Day 1 - 1.5h Post-dose 	 	 	 	
N 	72 	96 	168 	
Number of subjects with values below LLOQxMRD, n (%) 	0 	0 	0 	
 	 	 	 	
Day 1 - 2h Post-dose 	 	 	 	
N 	72 	96 	168 	
Number of subjects with values below LLOQxMRD, n (%) 	0 	0 	0 	
 	 	 	 	
Day 1 - 4h Post-dose 	 	 	 	
N 	72 	96 	168 	
Number of subjects with values below LLOQxMRD, n (%) 	0 	0 	0 	
 	 	 	 	
Day 1 - 0-6h Post-dose 	 	 	 	
N 	72 	96 	168 	
Number of subjects with values below LLOQxMRD, n (%) 	0 	0 	0 	
 	 	 	 	
Day 1 - 6h Post-dose 	 	 	 	
N 	72 	96 	168 	
Number of subjects with values below LLOQxMRD, n (%) 	0 	0 	0 	
 	 	 	 	
Day 1 - 8h Post-dose 	 	 	 	
N 	72 	96 	168 	
Number of subjects with values below LLOQxMRD, n (%) 	0 	0 	0 	
 	 	 	 	
Day 1 - 6-12h Post-dose 	 	 	 	
N 	72 	96 	168 	
Number of subjects with values below LLOQxMRD, n (%) 	0 	0 	0 	
 	 	 	 	
Day 1 - 12h Post-dose 	 	 	 	
N 	72 	96 	168 	
Number of subjects with values below LLOQxMRD, n (%) 	0 	0 	0 	
 	 	 	 	
Day 1 - 16h Post-dose 	 	 	 	
N 	72 	96 	168 	
Number of subjects with values below LLOQxMRD, n (%) 	0 	0 	0 	
 	 	 	 	
Day 1 - 12-24h Post-dose 	 	 	 	
N 	72 	96 	168 	
Number of subjects with values below LLOQxMRD, n (%) 	0 	0 	0 	
 	 	 	 	
Day 2 - 24h Post-dose 	 	 	 	
N 	72 	96 	168 	
Number of subjects with values below LLOQxMRD, n (%) 	0 	0 	0 	
 	 	 	 	
Day 2 - Pre-dose 	 	 	 	
N 	72 	94 	166 	
Number of subjects with values below LLOQxMRD, n (%) 	0 	0 	0 	
 	 	 	 	
Day 2 - 36h Post-dose 	 	 	 	
N 	72 	96 	168 	
Number of subjects with values below LLOQxMRD, n (%) 	72 (100.0%) 	96 (100.0%) 	168 (100.0%) 	
 	 	 	 	
Day 2 - 24-48h Post-dose 	 	 	 	
N 	72 	96 	168 	
Number of subjects with values below LLOQxMRD, n (%) 	51 (70.8%) 	76 (79.2%) 	127 (75.6%) 	
 	 	 	 	
Day 3 - 48h Post-dose 	 	 	 	
N 	72 	96 	168 	
Number of subjects with values below LLOQxMRD, n (%) 	72 (100.0%) 	96 (100.0%) 	168 (100.0%) 	
 	 	 	 	
Day 3 - Pre-dose 	 	 	 	
N 	72 	92 	164 	
Number of subjects with values below LLOQxMRD, n (%) 	72 (100.0%) 	92 (95.8%) 	164 (97.6%) 	

Key: MRD=minimum required dilution 	
Key: MRD=minimum required dilution	
Key: MRD=minimum required dilution	
Key: MRD=minimum required dilution