TSICM06:	Prior Medications; Safety Analysis Set (Study jjcs - core)						
 	Active Study Agent 	Active Study Agent 	Active Study Agent 	 	 	
ATC Level 1 	Xanomeline High Dose 	Xanomeline Low Dose 	Combined 	Placebo 	Total 	
  Base Preferred Term 	N=53 	N=73 	N=126 	N=59 	N=185 	
Subjects with ≥1 prior medication 	43 (81.1%) 	56 (76.7%) 	99 (78.6%) 	49 (83.1%) 	148 (80.0%) 	
 	 	 	 	 	 	
Uncoded 	42 (79.2%) 	54 (74.0%) 	96 (76.2%) 	47 (79.7%) 	143 (77.3%) 	
Uncoded: vitamin e 	8 (15.1%) 	10 (13.7%) 	18 (14.3%) 	12 (20.3%) 	30 (16.2%) 	
Uncoded: multivitamin 	8 (15.1%) 	11 (15.1%) 	19 (15.1%) 	9 (15.3%) 	28 (15.1%) 	
Uncoded: multivitamins 	8 (15.1%) 	5 (6.8%) 	13 (10.3%) 	6 (10.2%) 	19 (10.3%) 	
Uncoded: vitamin c 	5 (9.4%) 	5 (6.8%) 	10 (7.9%) 	5 (8.5%) 	15 (8.1%) 	
Uncoded: synthroid 	3 (5.7%) 	4 (5.5%) 	7 (5.6%) 	3 (5.1%) 	10 (5.4%) 	
Uncoded: tylenol 	3 (5.7%) 	3 (4.1%) 	6 (4.8%) 	4 (6.8%) 	10 (5.4%) 	
Uncoded: timoptic 	5 (9.4%) 	2 (2.7%) 	7 (5.6%) 	2 (3.4%) 	9 (4.9%) 	
Uncoded: centrum silver 	2 (3.8%) 	2 (2.7%) 	4 (3.2%) 	2 (3.4%) 	6 (3.2%) 	
Uncoded: ibuprofen 	0 	2 (2.7%) 	2 (1.6%) 	4 (6.8%) 	6 (3.2%) 	
Uncoded: motrin 	3 (5.7%) 	1 (1.4%) 	4 (3.2%) 	2 (3.4%) 	6 (3.2%) 	
Uncoded: ativan 	0 	3 (4.1%) 	3 (2.4%) 	2 (3.4%) 	5 (2.7%) 	
Uncoded: ecotrin 	0 	3 (4.1%) 	3 (2.4%) 	2 (3.4%) 	5 (2.7%) 	
Uncoded: estrogen nos 	3 (5.7%) 	0 	3 (2.4%) 	2 (3.4%) 	5 (2.7%) 	
Uncoded: ginkgo biloba 	1 (1.9%) 	3 (4.1%) 	4 (3.2%) 	1 (1.7%) 	5 (2.7%) 	
Uncoded: metamucil 	3 (5.7%) 	1 (1.4%) 	4 (3.2%) 	1 (1.7%) 	5 (2.7%) 	
Uncoded: provera 	1 (1.9%) 	2 (2.7%) 	3 (2.4%) 	2 (3.4%) 	5 (2.7%) 	
Uncoded: zestril 	2 (3.8%) 	1 (1.4%) 	3 (2.4%) 	2 (3.4%) 	5 (2.7%) 	
Uncoded: zocor 	1 (1.9%) 	1 (1.4%) 	2 (1.6%) 	3 (5.1%) 	5 (2.7%) 	
Uncoded: advil 	4 (7.5%) 	0 	4 (3.2%) 	0 	4 (2.2%) 	
Uncoded: asa 	3 (5.7%) 	0 	3 (2.4%) 	1 (1.7%) 	4 (2.2%) 	
Uncoded: claritin 	0 	3 (4.1%) 	3 (2.4%) 	1 (1.7%) 	4 (2.2%) 	
Uncoded: dyazide 	0 	4 (5.5%) 	4 (3.2%) 	0 	4 (2.2%) 	
Uncoded: vitamin b12 	0 	2 (2.7%) 	2 (1.6%) 	2 (3.4%) 	4 (2.2%) 	
Uncoded: zinc 	1 (1.9%) 	1 (1.4%) 	2 (1.6%) 	2 (3.4%) 	4 (2.2%) 	
Uncoded: betagan 	1 (1.9%) 	0 	1 (0.8%) 	2 (3.4%) 	3 (1.6%) 	
Uncoded: centrum 	1 (1.9%) 	1 (1.4%) 	2 (1.6%) 	1 (1.7%) 	3 (1.6%) 	
Uncoded: furosemide 	0 	3 (4.1%) 	3 (2.4%) 	0 	3 (1.6%) 	
Uncoded: garlic 	2 (3.8%) 	0 	2 (1.6%) 	1 (1.7%) 	3 (1.6%) 	
Uncoded: lopid 	2 (3.8%) 	1 (1.4%) 	3 (2.4%) 	0 	3 (1.6%) 	
Uncoded: monopril 	0 	2 (2.7%) 	2 (1.6%) 	1 (1.7%) 	3 (1.6%) 	
Uncoded: ocuvite 	1 (1.9%) 	0 	1 (0.8%) 	2 (3.4%) 	3 (1.6%) 	
Uncoded: potassium 	0 	2 (2.7%) 	2 (1.6%) 	1 (1.7%) 	3 (1.6%) 	
Uncoded: prilosec 	0 	2 (2.7%) 	2 (1.6%) 	1 (1.7%) 	3 (1.6%) 	
Uncoded: prinivil 	1 (1.9%) 	1 (1.4%) 	2 (1.6%) 	1 (1.7%) 	3 (1.6%) 	
Uncoded: tums 	1 (1.9%) 	1 (1.4%) 	2 (1.6%) 	1 (1.7%) 	3 (1.6%) 	
Uncoded: vitamins 	0 	3 (4.1%) 	3 (2.4%) 	0 	3 (1.6%) 	
Uncoded: accupril 	2 (3.8%) 	0 	2 (1.6%) 	0 	2 (1.1%) 	
Uncoded: acetaminophen 	0 	1 (1.4%) 	1 (0.8%) 	1 (1.7%) 	2 (1.1%) 	
Uncoded: altace 	0 	1 (1.4%) 	1 (0.8%) 	1 (1.7%) 	2 (1.1%) 	
Uncoded: aspirin (e.c.) 	0 	1 (1.4%) 	1 (0.8%) 	1 (1.7%) 	2 (1.1%) 	
Uncoded: b complex 	1 (1.9%) 	0 	1 (0.8%) 	1 (1.7%) 	2 (1.1%) 	
Uncoded: benadryl 	1 (1.9%) 	1 (1.4%) 	2 (1.6%) 	0 	2 (1.1%) 	
Uncoded: betacarotene 	0 	1 (1.4%) 	1 (0.8%) 	1 (1.7%) 	2 (1.1%) 	
Uncoded: bufferin 	1 (1.9%) 	1 (1.4%) 	2 (1.6%) 	0 	2 (1.1%) 	
Uncoded: calcium carbonate 	0 	0 	0 	2 (3.4%) 	2 (1.1%) 	
Uncoded: capoten 	0 	2 (2.7%) 	2 (1.6%) 	0 	2 (1.1%) 	
Uncoded: chloral hydrate 	1 (1.9%) 	1 (1.4%) 	2 (1.6%) 	0 	2 (1.1%) 	
Uncoded: excedrin 	1 (1.9%) 	1 (1.4%) 	2 (1.6%) 	0 	2 (1.1%) 	
Uncoded: glyburide 	1 (1.9%) 	1 (1.4%) 	2 (1.6%) 	0 	2 (1.1%) 	
Uncoded: herbal preparation 	1 (1.9%) 	0 	1 (0.8%) 	1 (1.7%) 	2 (1.1%) 	
Uncoded: hydrochlorothiazide 	1 (1.9%) 	0 	1 (0.8%) 	1 (1.7%) 	2 (1.1%) 	
Uncoded: hydrocortisone, topical 	1 (1.9%) 	1 (1.4%) 	2 (1.6%) 	0 	2 (1.1%) 	
Uncoded: hytrin 	1 (1.9%) 	1 (1.4%) 	2 (1.6%) 	0 	2 (1.1%) 	
Uncoded: lisinopril 	0 	2 (2.7%) 	2 (1.6%) 	0 	2 (1.1%) 	
Uncoded: milk of magnesia 	1 (1.9%) 	0 	1 (0.8%) 	1 (1.7%) 	2 (1.1%) 	
Uncoded: mylanta 	0 	0 	0 	2 (3.4%) 	2 (1.1%) 	
Uncoded: prednisone 	0 	1 (1.4%) 	1 (0.8%) 	1 (1.7%) 	2 (1.1%) 	
Uncoded: procardia 	2 (3.8%) 	0 	2 (1.6%) 	0 	2 (1.1%) 	
Uncoded: propine 	0 	0 	0 	2 (3.4%) 	2 (1.1%) 	
Uncoded: relafen 	0 	1 (1.4%) 	1 (0.8%) 	1 (1.7%) 	2 (1.1%) 	
Uncoded: theragran-m 	0 	1 (1.4%) 	1 (0.8%) 	1 (1.7%) 	2 (1.1%) 	
Uncoded: trusopt 	0 	0 	0 	2 (3.4%) 	2 (1.1%) 	
Uncoded: vitamin b 	0 	2 (2.7%) 	2 (1.6%) 	0 	2 (1.1%) 	
Uncoded: vitamin d 	1 (1.9%) 	0 	1 (0.8%) 	1 (1.7%) 	2 (1.1%) 	
Uncoded: aerobid 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Uncoded: albuterol 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Uncoded: alphagan 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Uncoded: ampicillin 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Uncoded: anti-oxidant 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: ascriptin 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: beconase 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: benzalkonium chloride 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Uncoded: calcium magnesium 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: central-vite 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Uncoded: charcoal, activated 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: cipro 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: cod-liver oil 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: daypro 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: debrox 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: dhea 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Uncoded: diabeta 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: diabinese 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: diprolene cream 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: dipyridamole 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: docusate 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: docusate sodium 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: estradiol 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Uncoded: eucerin creme 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Uncoded: ex-lax 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: feldene 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Uncoded: fibre, dietary 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: folic acid 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: fosamax 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: garamycin ophthalmic 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: ginseng 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Uncoded: glucotrol 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: hismanal 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: homeopatic preparation 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Uncoded: humulin n 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: hydrochlorothiazide with triamterene 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: indocin 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: influenza virus vaccine 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: iron 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: k-dur 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: keflex 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: levobunolol 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: levothroid 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: levoxine 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Uncoded: levoxyl 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Uncoded: lopressor 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: lorazepam 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: lotensin 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: maxzide 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: meclizine 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: medroxyprogesterone 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Uncoded: metrogel 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Uncoded: minerals nos 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: multivit 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Uncoded: nasacort 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: nasal spray 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: neptazane 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: nitro patch 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: nitrodisc 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: nitroglycerin 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: ocupress 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: papaya 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Uncoded: perdiem 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: persantine 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: pilocarpine hydrochloride 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Uncoded: pilostat 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Uncoded: pravastatin 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: premphase 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: promethazine hcl w/codeine 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Uncoded: propulsid 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: psorcon 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Uncoded: psyllium hydrophilic mucilloid 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: quercetin 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: quinamm 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: quinapril 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: quinine sulfate 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Uncoded: stresstabs 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: sudafed 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: sulindac 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: surfak 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: ticlid 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: timolol maleate 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: triamcinolone 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Uncoded: tylenol extra strength 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: tylenol w/codeine no. 4 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: ultram 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: vitamin a 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: vitamin b6 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: vitamins with minerals 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: zephrex 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Uncoded: zestoretic 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
 	 	 	 	 	 	
Nervous system 	3 (5.7%) 	8 (11.0%) 	11 (8.7%) 	15 (25.4%) 	26 (14.1%) 	
Acetylsalicylic acid 	3 (5.7%) 	8 (11.0%) 	11 (8.7%) 	14 (23.7%) 	25 (13.5%) 	
Alprazolam 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Sumatriptan 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
 	 	 	 	 	 	
Alimentary tract and metabolism 	4 (7.5%) 	8 (11.0%) 	12 (9.5%) 	7 (11.9%) 	19 (10.3%) 	
Calcium 	3 (5.7%) 	4 (5.5%) 	7 (5.6%) 	6 (10.2%) 	13 (7.0%) 	
Simeticone 	0 	2 (2.7%) 	2 (1.6%) 	0 	2 (1.1%) 	
Algeldrate 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Calcium carbonate 	1 (1.9%) 	0 	1 (0.8%) 	0 	1 (0.5%) 	
Loperamide hydrochloride 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Metformin hydrochloride 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
 	 	 	 	 	 	
Genito urinary system and sex hormones 	3 (5.7%) 	7 (9.6%) 	10 (7.9%) 	2 (3.4%) 	12 (6.5%) 	
Estrogens conjugated 	3 (5.7%) 	7 (9.6%) 	10 (7.9%) 	2 (3.4%) 	12 (6.5%) 	
 	 	 	 	 	 	
Cardiovascular system 	1 (1.9%) 	6 (8.2%) 	7 (5.6%) 	2 (3.4%) 	9 (4.9%) 	
Digoxin 	1 (1.9%) 	4 (5.5%) 	5 (4.0%) 	0 	5 (2.7%) 	
Fluvastatin 	0 	2 (2.7%) 	2 (1.6%) 	0 	2 (1.1%) 	
Nifedipine 	0 	0 	0 	2 (3.4%) 	2 (1.1%) 	
 	 	 	 	 	 	
Respiratory system 	3 (5.7%) 	0 	3 (2.4%) 	1 (1.7%) 	4 (2.2%) 	
Naproxen sodium 	3 (5.7%) 	0 	3 (2.4%) 	1 (1.7%) 	4 (2.2%) 	
 	 	 	 	 	 	
Antineoplastic and immunomodulating agents 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
Leuprorelin acetate 	0 	0 	0 	1 (1.7%) 	1 (0.5%) 	
 	 	 	 	 	 	
Blood and blood forming organs 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	
Ferrous sulfate 	0 	1 (1.4%) 	1 (0.8%) 	0 	1 (0.5%) 	

Note: Prior medications are defined as any therapy used before the day of first dose (partial or complete) of study treatment. 	
Note: Prior medications are defined as any therapy used before the day of first dose (partial or complete) of study treatment.	
Note: Prior medications are defined as any therapy used before the day of first dose (partial or complete) of study treatment.	
Note: Prior medications are defined as any therapy used before the day of first dose (partial or complete) of study treatment.	
Note: Prior medications are defined as any therapy used before the day of first dose (partial or complete) of study treatment.	
Note: Prior medications are defined as any therapy used before the day of first dose (partial or complete) of study treatment.